Skip to main content
Top
Published in: Updates in Surgery 2/2020

01-06-2020 | Editorial and Commentary

Pancreatic ductal adenocarcinoma: time for a neoadjuvant revolution?

Authors: Roberto Salvia, Giuseppe Malleo, Laura Maggino, Michele Milella, Claudio Bassi

Published in: Updates in Surgery | Issue 2/2020

Login to get access

Excerpt

In his landmark publication “The structure of scientific revolutions” Harvard Philosopher Thomas Kuhn challenged the traditional view of science as the progressive accumulation of knowledge, and affirmed the concept of “progress through revolutions”. In this framework, the reiteration of anomalies within a given conceptual network triggers a crisis whereby the underlying assumptions of the field are reexamined and a new paradigm is established. Maybe for the first time in the management of pancreatic ductal adenocarcinoma (PDAC), we are standing on the edge of such revolutionary shift. …
Literature
3.
go back to reference Von Hoff DD, Ervin T, Arena FP et al (2013) Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 369:1691–1703CrossRef Von Hoff DD, Ervin T, Arena FP et al (2013) Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 369:1691–1703CrossRef
4.
go back to reference Suker M, Beumer BR, Sadot E et al (2016) FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis. Lancet Oncol 17:801–810CrossRef Suker M, Beumer BR, Sadot E et al (2016) FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis. Lancet Oncol 17:801–810CrossRef
6.
go back to reference Jang J-Y, Han Y, Lee H et al (2018) Oncological benefits of neoadjuvant chemoradiation with gemcitabine versus upfront surgery in patients with borderline resectable pancreatic cancer: a prospective, randomized, open-label, multicenter phase 2/3 trial. Ann Surg 268:215–222CrossRef Jang J-Y, Han Y, Lee H et al (2018) Oncological benefits of neoadjuvant chemoradiation with gemcitabine versus upfront surgery in patients with borderline resectable pancreatic cancer: a prospective, randomized, open-label, multicenter phase 2/3 trial. Ann Surg 268:215–222CrossRef
7.
go back to reference Reni M, Balzano G, Zanon S et al (2018) Safety and efficacy of preoperative or postoperative chemotherapy for resectable pancreatic adenocarcinoma (PACT-15): a randomised, open-label, phase 2–3 trial. Lancet Gastroenterol Hepatol 3:413–423CrossRef Reni M, Balzano G, Zanon S et al (2018) Safety and efficacy of preoperative or postoperative chemotherapy for resectable pancreatic adenocarcinoma (PACT-15): a randomised, open-label, phase 2–3 trial. Lancet Gastroenterol Hepatol 3:413–423CrossRef
11.
go back to reference NCCN clinical practice guidelines in oncology. Pancreatic adenocarcinoma. National Comprehensive Cancer Network. 2020 version 1 NCCN clinical practice guidelines in oncology. Pancreatic adenocarcinoma. National Comprehensive Cancer Network. 2020 version 1
Metadata
Title
Pancreatic ductal adenocarcinoma: time for a neoadjuvant revolution?
Authors
Roberto Salvia
Giuseppe Malleo
Laura Maggino
Michele Milella
Claudio Bassi
Publication date
01-06-2020
Publisher
Springer International Publishing
Published in
Updates in Surgery / Issue 2/2020
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI
https://doi.org/10.1007/s13304-020-00798-3

Other articles of this Issue 2/2020

Updates in Surgery 2/2020 Go to the issue