Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Tumor Biology
Published in: Tumor Biology 11/2016

01-11-2016 | Original Article

MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway

Authors: Zhao Xiaohong, Fan Lichun, Xie Na, Zou Kejian, Xiao Xiaolan, Wang Shaosheng

Published in: Tumor Biology | Issue 11/2016

Login to get access

Abstract

MicroRNAs (miRNAs) play an important role in the tumorigenesis of ovarian cancer. Previously, we have reported the dysregulation of miR-203 in the ovarian cancer tissues. However, the biological functions and molecular mechanisms of miR-203 in ovarian cancer remain unknown. Here, we showed that the expression of miR-203 was increased in ovarian cancer tissues compared with the adjacent non-cancerous tissues and the transcription of miR-203 was inhibited by P53. Forced expression of miR-203 in ovarian cancer promoted cell growth and migration, while depletion of miR-203 inhibited the growth and migration of ovarian cancer cells. In addition, miR-203 promoted the metastasis of ovarian cancer cells in vivo and shorted the survival of the nude mice. Mechanically, miR-203 targeted the 3′-UTR of pyruvate dehydrogenase B (PDHB) and increased the consumption of glucose and the production of lactate. Overexpression of PDHB abolished the oncogenic effects of miR-203 on the growth of ovarian cancer cells. Together, our data suggested the oncogenic roles of miR-203 in ovarian cancer by promoting glycolysis, and miR-203 might be a therapeutic target for ovarian cancer.
Literature
1.
Chen HL et al. Galectin-7 regulates keratinocyte proliferation and differentiation through JNK-miR-203-p63 signaling. J Invest Dermatol. 2016;136(1):182–91.CrossRefPubMedPubMedCentral
2.
Georgantas 3rd RW et al. MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D. Pigment Cell Melanoma Res. 2014;27(2):275–86.CrossRefPubMed
3.
Goh WQ et al. DLAT subunit of the pyruvate dehydrogenase complex is upregulated in gastric cancer-implications in cancer therapy. Am J Transl Res. 2015;7(6):1140–51.PubMedPubMedCentral
4.
Khanmi, K., S. Ignacimuthu, and M.G. Paulraj. MicroRNA in prostate cancer. Clin Chim Acta. 2015 (Epub ahead of print)
5.
Li L et al. MiR-17-5p up-regulates YES1 to modulate the cell cycle progression and apoptosis in ovarian cancer cell lines. J Cell Biochem. 2015;116(6):1050–9.CrossRefPubMed
6.
Liao H et al. MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2. Oncotarget. 2015a;6(11):8914–28.CrossRefPubMedPubMedCentral
7.
Liao G, Panettieri RA, Tang DD. MicroRNA-203 negatively regulates c-Abl, ERK1/2 phosphorylation, and proliferation in smooth muscle cells. Physiol Rep. 2015b;3(9).
8.
9.
Mitamura T et al. Downregulation of miRNA-31 induces taxane resistance in ovarian cancer cells through increase of receptor tyrosine kinase MET. Oncogenesis. 2013;2:e40.CrossRefPubMedPubMedCentral
10.
Neungton N et al. p53 tumor suppressor gene mutation in ovarian cancer in Thai patients. J Med Assoc Thail. 2002;85(6):658–67.
11.
Qu JQ, et al. (2015) MiRNA-203 reduces nasopharyngeal carcinoma radioresistance by targeting IL8/AKT signaling. Mol Cancer Ther (Epub ahead of print)
12.
13.
Saunier, E., C. Benelli, and S. Bortoli. The pyruvate dehydrogenase complex in cancer: an old metabolic gatekeeper regulated by new pathways and pharmacological agents. Int J Cancer. 2015 (Epub ahead of print)
14.
Shi Y, et al. (2015) miR-203 suppression in gastric carcinoma promotes Slug-mediated cancer metastasis. Tumour Biol (Epub ahead of print)
15.
16.
Sun XR et al. Expression of pyruvate dehydrogenase is an independent prognostic marker in gastric cancer. World J Gastroenterol, 2015. 2015;21(17):5336–44.CrossRef
17.
Tian L et al. MiR-203 is downregulated in laryngeal squamous cell carcinoma and can suppress proliferation and induce apoptosis of tumours. Tumour Biol. 2014;35(6):5953–63.CrossRefPubMed
18.
Wan D, et al. (2015) miR-203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non-coding RNA HULC. Anticancer Agents Med Chem (Epub ahead of print)
19.
Wang S et al. Upregulation of microRNA-203 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer. Med Oncol. 2013a;30(3).
20.
Wang N et al. miR-203 suppresses the proliferation and migration and promotes the apoptosis of lung cancer cells by targeting SRC. PLoS One. 2014;9(8):e105570.CrossRefPubMedPubMedCentral
21.
Warshauer E et al. RBM28, a protein deficient in ANE syndrome, regulates hair follicle growth via miR-203 and p63. Exp Dermatol. 2015;24(8):618–22.CrossRefPubMed
22.
Wei W et al. miR-203 inhibits proliferation of HCC cells by targeting survivin. Cell Biochem Funct. 2013;31(1):82–5.CrossRefPubMed
23.
Wuerkenbieke D et al. miRNA-150 downregulation promotes pertuzumab resistance in ovarian cancer cells via AKT activation. Arch Gynecol Obstet. 2015;292(5):1109–16.CrossRefPubMed
24.
Ye Z et al. miR-30d blocked transforming growth factor beta1-induced epithelial-mesenchymal transition by targeting snail in ovarian cancer cells. Int J Gynecol Cancer. 2015;25(9):1574–81.CrossRefPubMed
25.
26.
Zhang F et al. MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer. Cancer Lett. 2014;342(1):121–9.CrossRefPubMed
27.
Zhou X et al. Down-regulation of miR-203 induced by Helicobacter pylori infection promotes the proliferation and invasion of gastric cancer by targeting CASK. Oncotarget. 2014a;5(22):11631–40.CrossRefPubMedPubMedCentral
28.
Zhou Y et al. miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase. Mol Oncol. 2014b;8(1):83–92.CrossRefPubMed
Metadata
Title
MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway
Authors
Zhao Xiaohong
Fan Lichun
Xie Na
Zou Kejian
Xiao Xiaolan
Wang Shaosheng
Publication date
01-11-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 11/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-016-5415-1

Other articles of this Issue 11/2016

Tumor Biology 11/2016 Go to the issue

Original Article

U/G SNP rs111904020 in 3′UTR of STAT3 regulated by miR-214 promotes hepatocellular carcinoma development in Chinese population

Original Article

The mitochondrion interfering compound NPC-26 exerts potent anti-pancreatic cancer cell activity in vitro and in vivo

Original Article

Hepatitis C virus promotes hepatocellular carcinogenesis by targeting TIPE2, a new regulator of DNA damage response

Original Article

MicroRNA-490 regulates lung cancer metastasis by targeting poly r(C)-binding protein 1

Original Article

miR-214 inhibits invasion and migration via downregulating GALNT7 in esophageal squamous cell cancer

Original Article

Potential role of Shh-Gli1-BMI1 signaling pathway nexus in glioma chemoresistance
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits