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01-09-2016 | Original Article

Overexpression of p42.3 promotes cell proliferation, migration, and invasion in human gastric cancer cells

Authors: Wen-Jia Cao, Wen-Qi Du, Lin-Lin Mao, Jun-Nian Zheng, Dong-Sheng Pei

Published in: Tumor Biology | Issue 9/2016

Abstract

As a newly discovered tumor-specific gene, p42.3 is overexpressed in most of human gastric cancers (GC). However, the role of p42.3 in GC progression remains unclear. To assess the role of p42.3 in gastric cancers, immunohistochemistry and western blot were performed to detect the p42.3 expression in human GC tissues and cells. We also investigated the role of p42.3 in GC cell proliferation, migration, and invasion. Our results showed that the p42.3 expression was increased dramatically in human GC tissue and cells. In addition, we found that overexpression of p42.3 promotes GC cell proliferation, migration, and invasion abilities. Furthermore, p42.3 expression suppressed the E-cadherin protein level and promoted the β-catenin and p-ERK protein level. Taken together, overexpressed p42.3 is correlated with gastric cancer cell proliferation, migration, and invasion, suggesting its use as a biological marker in gastric cancer.

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Title: Overexpression of p42.3 promotes cell proliferation, migration, and invasion in human gastric cancer cells
Authors: Wen-Jia Cao
Wen-Qi Du
Lin-Lin Mao
Jun-Nian Zheng
Dong-Sheng Pei
Publication date: 01-09-2016
Publisher: Springer Netherlands
Published in: Tumor Biology / Issue 9/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-016-5242-4

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