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Tumor Biology
Published in: Tumor Biology 8/2016

01-08-2016 | Review

Mechanisms of tumor cell resistance to the current targeted-therapy agents

Authors: Gholamreza Khamisipour, Farhad Jadidi-Niaragh, Abdolreza Sotoodeh Jahromi, Keivan zandi, Mohammad Hojjat-Farsangi

Published in: Tumor Biology | Issue 8/2016

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Abstract

Resistance to chemotherapy agents is a major challenge infront of cancer patient treatment and researchers. It is known that several factors, such as multidrug resistance proteins and ATP-binding cassette families, are cell membrane transporters that can efflux several substrates such as chemotherapy agents from the cell cytoplasm. To reduce the adverse effects of chemotherapy agents, various targeted-based cancer therapy (TBCT) agents have been developed. TBCT has revolutionized cancer treatment, and several agents have shown more specific effects on tumor cells than chemotherapies. Small molecule inhibitors and monoclonal antibodies are specific agents that mostly target tumor cells but have low side effects on normal cells. Although these agents have been very useful for cancer treatment, however, the presence of natural and acquired resistance has blunted the advantages of targeted therapies. Therefore, development of new options might be necessary. A better understanding of tumor cell resistance mechanisms to current treatment agents may provide an appropriate platform for developing and improving new treatment modalities. Therefore, in this review, different mechanisms of tumor cell resistance to chemotherapy drugs and current targeted therapies have been described.
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Metadata
Title
Mechanisms of tumor cell resistance to the current targeted-therapy agents
Authors
Gholamreza Khamisipour
Farhad Jadidi-Niaragh
Abdolreza Sotoodeh Jahromi
Keivan zandi
Mohammad Hojjat-Farsangi
Publication date
01-08-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 8/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-016-5059-1

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