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Tumor Biology
Published in: Tumor Biology 8/2016

01-08-2016 | Original Article

Decreased expression of Siglec-8 associates with poor prognosis in patients with gastric cancer after surgical resection

Authors: Yifan Cao, Hao Liu, Heng Zhang, Chao Lin, Ruochen Li, Weijuan Zhang, Zhenbin Shen, Jiejie Xu

Published in: Tumor Biology | Issue 8/2016

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Abstract

The expression of sialic acid-binding Ig-like lectin (Siglec) family has been detected in many malignant tumors and correlated with patient outcomes. The present study aims to investigate the prognostic value of Siglec-8 expression and refine current risk stratification system in patients with gastric cancer. Two independent sets of patients (n = 78; n = 356, respectively) with gastric cancer from Zhongshan Hospital were enrolled into this study. The expression of Siglec-8 was detected by immunohistochemistry. Cox regression analysis was used to assess the prognostic value of Siglec-8 expression and clinical outcomes. A novel molecular prognostic stratification system combining intratumoral Siglec-8 expression with TNM stage was determined by means of receiver operating characteristic analysis. Multivariate Cox regression analysis identified that intratumoral Siglec-8 low expression was an independent prognostic factor for dismal overall survival of patients with gastric cancer. Incorporating intratumoral Siglec-8 expression into the current TNM staging system showed more accuracy for predicting prognosis of patients with gastric cancer. Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer. Incorporating Siglec-8 expression level into current TNM staging system might add more comprehensive prognostic information for patients with gastric cancer and lead to a more precise risk stratification system for predicting clinical outcomes.
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Metadata
Title
Decreased expression of Siglec-8 associates with poor prognosis in patients with gastric cancer after surgical resection
Authors
Yifan Cao
Hao Liu
Heng Zhang
Chao Lin
Ruochen Li
Weijuan Zhang
Zhenbin Shen
Jiejie Xu
Publication date
01-08-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 8/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-016-4859-7

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