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Tumor Biology
Published in: Tumor Biology 4/2016

01-04-2016 | Original Article

Function analysis of rs9589207 polymorphism in miR-92a in gastric cancer

Authors: Changming Liu, Ying Zhang, Haijun Chen, Lixing Jiang, Daping Xiao

Published in: Tumor Biology | Issue 4/2016

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Abstract

MiR-92a was identified as an essential oncogene by promoting the cell proliferation through FBXW7 in gastric cancer (GC). The function of the single nucleotide polymorphism (SNP) located in the mature region of miR-92a (rs9589207) has not been investigated. We found that rs9589207 in miR-92a was involved in the occurrence of GC by acting as a tumor protective factor and was highly associated with tumor size in GC patients instead of tumor number or metastasis in 554 GC patients and 531 cancer-free controls. Besides, the AA genotype in miR-92a could attenuate the promoting function of miR-92a in cell proliferation with an incapacitation in downregulating the expression of FBXW7. In conclusion, rs9589207 in miR-92a was highly associated with a decreased risk of GC in Chinese Han population and might serve as a novel biomarker for the disease.
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Metadata
Title
Function analysis of rs9589207 polymorphism in miR-92a in gastric cancer
Authors
Changming Liu
Ying Zhang
Haijun Chen
Lixing Jiang
Daping Xiao
Publication date
01-04-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 4/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-4288-z

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