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Tumor Biology
Published in: Tumor Biology 4/2016

01-04-2016 | Original Article

Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma

Authors: Wenjian Yao, Yu Bai, Yan Li, Ling Guo, Ping Zeng, Yonglian Wang, Bo Qi, Shangguo Liu, Xiuguang Qin, Yongzhen Li, Baosheng Zhao

Published in: Tumor Biology | Issue 4/2016

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Abstract

The aim of this study is to investigate whether metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) can be used as a potential therapy target for human esophageal squamous cell carcinoma. MALAT-1 expression levels were detected in 137 paired EC samples and adjacent nonneoplastic tissues. Human esophageal carcinoma cell lines EC9706 and KYSE150 were transfected with MALAT-1 small interference RNA. Cell proliferation, migration/invasion ability, cell cycle, and apoptosis were assessed. MALAT-1 expressed higher levels in esophageal cancer tissues when compared with paired adjacent normal tissues. This high expression was associated with a decreased survival rate. MALAT-1 knockdown induced a decrease in proliferation-enhanced apoptosis, inhibited migration/invasion, and reduced colony formation and led to cell cycle arrest at the G2/M phase. These data indicates that MALAT-1 could be exploited for therapeutic benefit.
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Metadata
Title
Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma
Authors
Wenjian Yao
Yu Bai
Yan Li
Ling Guo
Ping Zeng
Yonglian Wang
Bo Qi
Shangguo Liu
Xiuguang Qin
Yongzhen Li
Baosheng Zhao
Publication date
01-04-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 4/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-4223-3

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