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Tumor Biology
Published in: Tumor Biology 2/2016

01-02-2016 | Original Article

The transmembrane transporter ABCC3 participates in liver cancer progression and is a potential biomarker

Authors: Gabriela Carrasco-Torres, Samia Fattel-Fazenda, Guadalupe Soledad López-Alvarez, Rebeca García-Román, Saúl Villa-Treviño, Verónica Rocío Vásquez-Garzón

Published in: Tumor Biology | Issue 2/2016

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Abstract

The poor prognosis, few available treatment options, and multidrug resistance present in hepatocellular carcinoma are major problems, and new early biomarkers are needed to reduce the liver cancer death rate. ATP-binding cassette sub-family C member 3 (Abcc3) is overexpressed in different cancers and is associated with multidrug resistance and a carcinogenic stem cell phenotype. We present evidence for the first time that ABCC3 is a potential sanguine biomarker and anticancer target in hepatocellular carcinoma. Abcc3 mRNA expression was elevated in liver nodules and tumors in rat hepatocarcinogenesis model. Accordingly, the ABCC3 protein was preferentially overexpressed within the nodules and tumors during hepatocellular carcinoma progression and was secreted into the bloodstream of rat hepatocarcinogenesis model. The ABCC3 protein was expressed in human hepatoma cells and, importantly, was also present in HepG2- and Huh7-conditioned media. Furthermore, ABCC3 was overexpressed in human hepatocellular carcinoma. This report is the first to describe liver overexpression of Abcc3 during the cancer initiation, promotion, and progression periods in rat hepatocarcinogenesis model and in human hepatocellular carcinoma.
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Metadata
Title
The transmembrane transporter ABCC3 participates in liver cancer progression and is a potential biomarker
Authors
Gabriela Carrasco-Torres
Samia Fattel-Fazenda
Guadalupe Soledad López-Alvarez
Rebeca García-Román
Saúl Villa-Treviño
Verónica Rocío Vásquez-Garzón
Publication date
01-02-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 2/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3999-5

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