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Tumor Biology
Published in: Tumor Biology 2/2016

01-02-2016 | Original Article

Prognostic values of Notch receptors in breast cancer

Authors: Junming Xu, Fangbin Song, Tao Jin, Jun Qin, Junyi Wu, Min Wang, Ye Wang, Jun Liu

Published in: Tumor Biology | Issue 2/2016

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Abstract

Notch receptors are frequently deregulated in several human malignancies including human breast cancer. Activation of Notch has been reported to cause mammary carcinomas in mice. However, the prognostic value of individual Notch receptors in breast cancer (BC) patients remains elusive. In the current study, we investigated the prognostic value of Notch receptors in human BC patients. More specifically, we investigated the prognostic value of four Notch receptors in breast cancer patients through “the Kaplan-Meier plotter” (KM plotter) database, in which updated gene expression data and survival information are from a total of 3554 breast cancer patients. Our results showed that Notch1 messenger RNA (mRNA) high expression was correlated to worsen overall survival (OS) in PgR-negative BC patients. Notch2, Notch3, and Notch4 mRNA high expressions were found to be correlated to better OS for all breast cancer patients. Notch2 was also found to be correlated to better OS in lymph node-negative breast cancer patients and HER2-positive breast cancer patients. These results will be useful for better understanding of the heterogeneity and complexity in the molecular biology of breast cancer and for developing tools to more accurately predict their prognosis and design their customized treatment strategies.
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Metadata
Title
Prognostic values of Notch receptors in breast cancer
Authors
Junming Xu
Fangbin Song
Tao Jin
Jun Qin
Junyi Wu
Min Wang
Ye Wang
Jun Liu
Publication date
01-02-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 2/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3961-6

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