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Published in: Tumor Biology 1/2016

01-01-2016 | Original Article

Prognostic analysis of primary mucin-producing adenocarcinoma of the lung: a comprehensive retrospective study

Authors: Yang Qu, Dan Zhao, Jing Mu, Nanying Che, Chen Zhang, Zichen Liu, Dan Su, Lijuan Zhou, Haiqing Zhang, Lixin Wei

Published in: Tumor Biology | Issue 1/2016

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Abstract

Although primary mucin-producing adenocarcinoma of the lung is uncommon, each subtype has distinct clinical, pathological, molecular, and prognostic characteristics. This study aimed to determine correlations between clinical and pathological features and genetic phenotypes with the prognosis. We immunohistochemically examined the protein levels of thyroid transcription factor 1 (TTF-1), Napsin A, and anaplastic lymphoma kinase (ALK) and genetically examined epidermal growth factor receptor (EGFR) and KRAS mutations in these mucin-producing tumors. A total of 75 cases of mucin-producing adenocarcinoma of the lung were examined. ALK protein positivity was 33.3 % (25/75), and primarily occurred in solid predominant with mucin production subtype (SA). KRAS mutations occurred in 22.7 % (17/75) of patients, predominantly in invasive mucinous adenocarcinoma (IMA). Positive TTF-1 and Napsin A expression was more common in SA, while they were both negative in IMA. The 1-, 3-, and 5-year progression-free survival rates of mucin-producing lung adenocarcinoma were 85, 64, and 38 %, respectively; the overall survival rates were 90, 67, and 50 %, respectively. Larger tumors, advanced stage, and lymph node metastasis were associated with poor prognosis. Mucinous minimally invasive adenocarcinoma (m-MIA) had the best prognosis, followed by IMA, SA, and acinar or papillary predominant adenocarcinoma with mucin production (A/P). KRAS mutations were an independent positive prognostic factor for postoperative progress.
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Metadata
Title
Prognostic analysis of primary mucin-producing adenocarcinoma of the lung: a comprehensive retrospective study
Authors
Yang Qu
Dan Zhao
Jing Mu
Nanying Che
Chen Zhang
Zichen Liu
Dan Su
Lijuan Zhou
Haiqing Zhang
Lixin Wei
Publication date
01-01-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 1/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3869-1

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