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Tumor Biology
Published in: Tumor Biology 1/2016

Open Access 01-01-2016 | Research Article

MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer

Authors: Yan-Ying Xu, Jing Tian, Quan Hao, Li-Rong Yin

Published in: Tumor Biology | Issue 1/2016

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Abstract

MicroRNAs (miRNAs) are a class of noncoding RNAs and function as key regulators of gene expression at the post-transcriptional level. In this study, we found that miR-495 reduces cell growth, induces apoptosis and suppresses the migration of endometrial cancer by directly inhibiting FOXC1 expression. Further analysis revealed that FOXC1 promotes growth and migration and functions as an oncogene in vitro. FOXC1 overexpression reversed the cellular responses mediated by miR-495 in endometrial cancer cells. We also found that miR-495 suppresses the growth of endometrial cancer in vivo. Altogether, these results indicate that miR-495 acts as a tumour suppressor gene by targeting FOXC1 at the post-transcriptional level in endometrial cancer.
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Metadata
Title
MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer
Authors
Yan-Ying Xu
Jing Tian
Quan Hao
Li-Rong Yin
Publication date
01-01-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 1/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3686-6

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