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Tumor Biology
Published in: Tumor Biology 6/2015

01-06-2015 | Review

Autophagy and its function in radiosensitivity

Authors: Yan Yang, Yuehua Yang, Xi Yang, Hongcheng Zhu, Qing Guo, Xiaochen Chen, Hao Zhang, Hongyan Cheng, Xinchen Sun

Published in: Tumor Biology | Issue 6/2015

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Abstract

Autophagy differs from apoptosis and is independent of phagocytes by the appearance of autophagosomes, autolysosomes, and complete nuclei in the cell. This process significantly contributes to the antineoplastic effects of radiation. Radiation is an important strategy in cancer treatment; however, many types of cancer show radioresistance. The effects of radiotherapy are affected by factors, including the degree of tumor tissue hypoxia, the ability to repair DNA damage, and the presence of cancer stem cells. We review the relationships among autophagy, the three factors in cancer radiation, and the possible underlying molecular mechanisms. The therapeutic implications of these relationships and mechanisms in clinical settings are also discussed.
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Metadata
Title
Autophagy and its function in radiosensitivity
Authors
Yan Yang
Yuehua Yang
Xi Yang
Hongcheng Zhu
Qing Guo
Xiaochen Chen
Hao Zhang
Hongyan Cheng
Xinchen Sun
Publication date
01-06-2015
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 6/2015
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3496-x

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