Skip to main content
Top
Published in: Tumor Biology 12/2015

01-12-2015 | Editorial

The association between methylenetetrahydrofolate reductase gene C677T polymorphisms and breast cancer risk in Chinese population

Authors: Yadong Wang, Haiyan Yang, Huiyan Gao, Haiyu Wang

Published in: Tumor Biology | Issue 12/2015

Login to get access

Abstract

With great interest, we read the recent article entitled “Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies” published online in Tumor Biology, 2014, 35: 1695–1701. This article suggests that methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism was significantly associated with breast cancer risk in Chinese population. The result is encouraging. Nevertheless, three key issues in this meta-analysis are worth noticing.
Literature
1.
go back to reference Liang H, Yan Y, Li T, Li R, Li M, Li S, et al. Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies. Tumour Biol. 2014;35:1695–701.CrossRefPubMed Liang H, Yan Y, Li T, Li R, Li M, Li S, et al. Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies. Tumour Biol. 2014;35:1695–701.CrossRefPubMed
2.
go back to reference Lin WY, Chou YC, Wu MH, Huang HB, Jeng YL, Wu CC, et al. The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan. Anticancer Res. 2004;24:3863–8.PubMed Lin WY, Chou YC, Wu MH, Huang HB, Jeng YL, Wu CC, et al. The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan. Anticancer Res. 2004;24:3863–8.PubMed
3.
go back to reference Han H, Han L, Gao H, Hou L. Genetic polymorphisms of methylenetetrahydrofolate reductase, methionine synthase, methylation of NF2, and their association with breast cancer morbidity. Chin J Curr Adv Gen Surg. 2011;14:846–50. Han H, Han L, Gao H, Hou L. Genetic polymorphisms of methylenetetrahydrofolate reductase, methionine synthase, methylation of NF2, and their association with breast cancer morbidity. Chin J Curr Adv Gen Surg. 2011;14:846–50.
4.
go back to reference Wu Y, Wu L, Wang Y, Cao W, Hou L. Relation between the SNPs in methylenetetrahydrofolate reductase gene C677T and G1793A and the susceptibility of sporadic breast cancer. Prog Mod Biomed. 2012;12:2609–14. Wu Y, Wu L, Wang Y, Cao W, Hou L. Relation between the SNPs in methylenetetrahydrofolate reductase gene C677T and G1793A and the susceptibility of sporadic breast cancer. Prog Mod Biomed. 2012;12:2609–14.
5.
go back to reference Gao CM, Tang JH, Cao HX, Ding JH, Wu JZ, Wang J, et al. MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women. J Hum Genet. 2009;54:414–8.CrossRefPubMed Gao CM, Tang JH, Cao HX, Ding JH, Wu JZ, Wang J, et al. MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women. J Hum Genet. 2009;54:414–8.CrossRefPubMed
6.
go back to reference Cheng CW, Yu JC, Huang CS, Shieh JC, Fu YP, Wang HW, et al. Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan. Breast Cancer Res Treat. 2008;111:145–55.CrossRefPubMed Cheng CW, Yu JC, Huang CS, Shieh JC, Fu YP, Wang HW, et al. Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan. Breast Cancer Res Treat. 2008;111:145–55.CrossRefPubMed
7.
go back to reference He JM, Pu YD, Wu YJ, Qin R, Zhang QJ, Sun YS, et al. Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer. Genet Mol Res. 2014;13:8925–31.CrossRefPubMed He JM, Pu YD, Wu YJ, Qin R, Zhang QJ, Sun YS, et al. Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer. Genet Mol Res. 2014;13:8925–31.CrossRefPubMed
8.
go back to reference Hua Z, Wang Y, Ni J, Ge F, Zou T. Folic acid, vitamin B12, MTHFR, MS gene polymorphisms associate with the risk of breast cancer. Mod Oncol. 2011;19:428–31. Hua Z, Wang Y, Ni J, Ge F, Zou T. Folic acid, vitamin B12, MTHFR, MS gene polymorphisms associate with the risk of breast cancer. Mod Oncol. 2011;19:428–31.
9.
go back to reference Huang CY, Chang WS, Shui HA, Hsieh YH, Loh CH, Wang HC, et al. Evaluation of the contribution of methylenetetrahydrofolate reductase genotypes to Taiwan breast cancer. Anticancer Res. 2014;34:4109–15.PubMed Huang CY, Chang WS, Shui HA, Hsieh YH, Loh CH, Wang HC, et al. Evaluation of the contribution of methylenetetrahydrofolate reductase genotypes to Taiwan breast cancer. Anticancer Res. 2014;34:4109–15.PubMed
10.
go back to reference Inoue M, Robien K, Wang R, Van Den Berg DJ, Koh WP, Yu MC. Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study. Carcinogenesis. 2008;29:1967–72.CrossRefPubMedPubMedCentral Inoue M, Robien K, Wang R, Van Den Berg DJ, Koh WP, Yu MC. Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study. Carcinogenesis. 2008;29:1967–72.CrossRefPubMedPubMedCentral
11.
go back to reference Kan X, Zou T, Wu X, Wang X. Association between MTHFR genotype polymorphism and breast cancer susceptibility in human population from Yunnan. Cancer Res Prev Treat. 2007;34:716–8. Kan X, Zou T, Wu X, Wang X. Association between MTHFR genotype polymorphism and breast cancer susceptibility in human population from Yunnan. Cancer Res Prev Treat. 2007;34:716–8.
12.
go back to reference Li W, Chen S. MTHFR C677T gene polymorphism associated with breast cancer. Pract J Med. 2009;25:2031–3. Li W, Chen S. MTHFR C677T gene polymorphism associated with breast cancer. Pract J Med. 2009;25:2031–3.
13.
go back to reference Liu Y, Zhou LS, Xu XM, Deng LQ, Xiao QK. Association of dietary intake of folate, vitamin B6 and B12 and MTHFR genotype with breast cancer risk. Asian Pac J Cancer Prev. 2013;14:5189–92.CrossRefPubMed Liu Y, Zhou LS, Xu XM, Deng LQ, Xiao QK. Association of dietary intake of folate, vitamin B6 and B12 and MTHFR genotype with breast cancer risk. Asian Pac J Cancer Prev. 2013;14:5189–92.CrossRefPubMed
14.
go back to reference Qi J, Miao XP, Tan W, Yu CY, Liang G, Lu WF, et al. Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer. Zhonghua Zhong Liu Za Zhi. 2004;26:287–9.PubMed Qi J, Miao XP, Tan W, Yu CY, Liang G, Lu WF, et al. Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer. Zhonghua Zhong Liu Za Zhi. 2004;26:287–9.PubMed
15.
go back to reference Qiao J, Jiao D, Lu Z, Cui S, Liu Z. Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B12 intakes. Tumor Biol. 2014;35:11895–901.CrossRef Qiao J, Jiao D, Lu Z, Cui S, Liu Z. Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B12 intakes. Tumor Biol. 2014;35:11895–901.CrossRef
16.
go back to reference Shrubsole MJ, Gao YT, Cai Q, Shu XO, Dai Q, Hebert JR, et al. MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev. 2004;13:190–6.CrossRefPubMed Shrubsole MJ, Gao YT, Cai Q, Shu XO, Dai Q, Hebert JR, et al. MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev. 2004;13:190–6.CrossRefPubMed
17.
go back to reference Wu XY, Ni J, Xu WJ, Zhou T, Wang X. Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese population. Asian Pac J Cancer Prev. 2012;13:2199–206.CrossRefPubMed Wu XY, Ni J, Xu WJ, Zhou T, Wang X. Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese population. Asian Pac J Cancer Prev. 2012;13:2199–206.CrossRefPubMed
18.
go back to reference Xi J, Su Y, Fadiel A, Lin Y, Su F, Jia W, et al. Association of physical activity and polymorphisms in FGFR2 and DNA methylation related genes with breast cancer risk. Cancer Epidemiol. 2014;38:708–14.CrossRefPubMed Xi J, Su Y, Fadiel A, Lin Y, Su F, Jia W, et al. Association of physical activity and polymorphisms in FGFR2 and DNA methylation related genes with breast cancer risk. Cancer Epidemiol. 2014;38:708–14.CrossRefPubMed
19.
go back to reference Yu CP, Wu MH, Chou YC, Yang T, You SL, Chen CJ, et al. Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in Taiwan. Anticancer Res. 2007;27:1727–32.PubMed Yu CP, Wu MH, Chou YC, Yang T, You SL, Chen CJ, et al. Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in Taiwan. Anticancer Res. 2007;27:1727–32.PubMed
20.
go back to reference Yuan H, Xu X, Wang Z. The relation between polymorphism of methylenetetrahydrofolate reductase C677T and the risk of breast cancer. J Mudanjiang Med Univ. 2009;30:2–4. Yuan H, Xu X, Wang Z. The relation between polymorphism of methylenetetrahydrofolate reductase C677T and the risk of breast cancer. J Mudanjiang Med Univ. 2009;30:2–4.
Metadata
Title
The association between methylenetetrahydrofolate reductase gene C677T polymorphisms and breast cancer risk in Chinese population
Authors
Yadong Wang
Haiyan Yang
Huiyan Gao
Haiyu Wang
Publication date
01-12-2015
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 12/2015
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3321-6

Other articles of this Issue 12/2015

Tumor Biology 12/2015 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine