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Tumor Biology
Published in: Tumor Biology 4/2015

01-04-2015 | Research Article

Lung metastasis of pancreatic carcinoma is regulated by TGFβ signaling

Authors: Liqiang Song, Ping Wang, Yu Tian, De Chang, Kailong Li, Yongna Fan, Jing Shen, Hongzhen Du, Ruifang Mi, Xiaoxia Bian, Xianchao Tang

Published in: Tumor Biology | Issue 4/2015

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Abstract

The molecular regulation of the lung metastasis of pancreatic carcinoma (PCC) is not completely understood. Here, we show that the levels of phosphorylated SMAD3, ZEB1, ZEB2, Snail1, and Snail2 were significantly higher in PCC with lung metastasis than in PCC without lung metastasis. Overexpression of TGFβ1 enhanced the invasiveness of PCC cells, while inhibition of TGFβ1 decreased the invasiveness of PCC cells, which appeared to be conducted by activated TGFβ receptor signaling-induced upregulation of ZEB1, ZEB2, Snail1, and Snail2, suggesting a process of epithelial-mesenchymal transition (EMT). Taken together, our study provides evidence that TGFβ receptor signaling-induced EMT may be responsible for the increased PCC invasiveness to enhance its lung metastasis.
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Metadata
Title
Lung metastasis of pancreatic carcinoma is regulated by TGFβ signaling
Authors
Liqiang Song
Ping Wang
Yu Tian
De Chang
Kailong Li
Yongna Fan
Jing Shen
Hongzhen Du
Ruifang Mi
Xiaoxia Bian
Xianchao Tang
Publication date
01-04-2015
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 4/2015
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-014-2834-8

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