Letter regarding Wang et al. entitled “Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systematic review and meta-analysis”

Excerpt

We have read with interest the article by Wang et al. [1] in a recent issue of Tumor Biology. In this study, the authors conducted a systematic review and meta-analysis to assess the effects of two murine double minute 2 (MDM2) polymorphisms, rs2274799 and rs160916, on the risk and survival of osteosarcoma. The authors concluded that MDM2 polymorphisms had effects on the risk but had no effect on the survival of patients with osteosarcoma. In a recent letter to the editor, Liu et al. [2] detected several weaknesses in the meta-analysis. Firstly, they criticize the small number of papers included in the analyses, which could lead to false significant associations. They also point out the lack of information in the methods used to select the studies. Moreover, they comment the absence of Hardy-Weinberg equilibrium analysis in the control population. Finally, they question the quality of the selected studies. In the present letter, we would like to add some other inaccuracies found in the Wang et al. [1] meta-analysis. …