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Tumor Biology
Published in: Tumor Biology 6/2014

01-06-2014 | Research Article

Rsf-1 overexpression in human prostate cancer, implication as a prognostic marker

Authors: Hui Li, Yi Zhang, Yue Zhang, Xue Bai, Yang Peng, Ping He

Published in: Tumor Biology | Issue 6/2014

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Abstract

Rsf-1 (HBXAP) was recently reported to be overexpressed in various cancers and associated with the malignant behavior of cancer cells. However, the expression of Rsf-1 and its clinical significance in human prostate cancer have not been reported. In the present study, we analyzed the expression pattern of Rsf-1 in human prostate cancer tissues and found that Rsf-1 was overexpressed in 45 % of prostate cancer specimens. There was a significant association between Rsf-1 overexpression and tumor stage (p = 0.0039) and preoperative PSA level (p = 0.015). Furthermore, Rsf-1 overexpression correlated with poor biomedical recurrence-free survival in prostate cancer patients (p < 0.001). Rsf-1 overexpression could serve as an independent predictor for poor recurrence-free survival (p = 0.012). In addition, small interfering RNA (siRNA) knockdown in DU145 cells with high endogenous Rsf-1 expression decrease cell proliferation, colony formation, and invasion. In conclusion, Rsf-1 is overexpressed in human prostate cancers and serves as a novel prognostic marker. Rsf-1 contributes to prostate cancer cell growth and invasion, which makes it a candidate therapeutic target.
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Metadata
Title
Rsf-1 overexpression in human prostate cancer, implication as a prognostic marker
Authors
Hui Li
Yi Zhang
Yue Zhang
Xue Bai
Yang Peng
Ping He
Publication date
01-06-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 6/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-014-1766-7

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