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Published in: Tumor Biology 4/2014

01-04-2014 | Research Article

The volume and duration of wound drainage are independent prognostic factors for breast cancer

Authors: Yan Zhang, Hua Gao, Wei Gao

Published in: Tumor Biology | Issue 4/2014

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Abstract

Drain insertion is routinely done after breast cancer surgery. However, the prognostic value of suction drains in breast cancer is still unknown. This study aimed to reveal the prognostic value of drain insertion in breast cancer. A total of 296 female breast cancer patients undergoing surgery were retrospectively recruited. The correlation of drainage volume as well as drain duration with clinicopathological parameters and prognosis was assessed statistically. We found that breast cancer patients with a drainage volume of >240 ml had a better overall survival time. Breast cancer patients with more than 5 days postoperative drain duration would have better survival time. In addition, both the volume and duration of wound drainage are independent prognostic factors in multivariate analysis. Therefore, the volume of drainage as well as drain duration is a potential novel prognostic marker for breast cancer.
Literature
1.
2.
go back to reference Goldhirsch A, Wood WC, Gelber RD, Coates AS, Thurlimann B, Senn HJ. Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer. J Clin Oncol. 2003;21:3357–65.PubMedCrossRef Goldhirsch A, Wood WC, Gelber RD, Coates AS, Thurlimann B, Senn HJ. Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer. J Clin Oncol. 2003;21:3357–65.PubMedCrossRef
3.
go back to reference Kuroi K, Shimozuma K, Taguchi T, Imai H, Yamashiro H, Ohsumi S, et al. Pathophysiology of seroma in breast cancer. Breast Cancer. 2005;12:288–93.PubMedCrossRef Kuroi K, Shimozuma K, Taguchi T, Imai H, Yamashiro H, Ohsumi S, et al. Pathophysiology of seroma in breast cancer. Breast Cancer. 2005;12:288–93.PubMedCrossRef
4.
go back to reference Woodworth PA, McBoyle MF, Helmer SD, Beamer RL. Seroma formation after breast cancer surgery: incidence and predicting factors. Am Surg. 2000;66:444–50. discussion 450–441.PubMed Woodworth PA, McBoyle MF, Helmer SD, Beamer RL. Seroma formation after breast cancer surgery: incidence and predicting factors. Am Surg. 2000;66:444–50. discussion 450–441.PubMed
5.
go back to reference Sakkary MA. The value of mastectomy flap fixation in reducing fluid drainage and seroma formation in breast cancer patients. World J Surg Oncol. 2012;10:8.PubMedCentralPubMedCrossRef Sakkary MA. The value of mastectomy flap fixation in reducing fluid drainage and seroma formation in breast cancer patients. World J Surg Oncol. 2012;10:8.PubMedCentralPubMedCrossRef
6.
go back to reference Lumachi F, Brandes AA, Burelli P, Basso SM, Iacobone M, Ermani M. Seroma prevention following axillary dissection in patients with breast cancer by using ultrasound scissors: a prospective clinical study. Eur J Surg Oncol. 2004;30:526–30.PubMedCrossRef Lumachi F, Brandes AA, Burelli P, Basso SM, Iacobone M, Ermani M. Seroma prevention following axillary dissection in patients with breast cancer by using ultrasound scissors: a prospective clinical study. Eur J Surg Oncol. 2004;30:526–30.PubMedCrossRef
7.
go back to reference Shamley DR, Barker K, Simonite V, Beardshaw A. Delayed versus immediate exercises following surgery for breast cancer: a systematic review. Breast Cancer Res Treat. 2005;90:263–71.PubMedCrossRef Shamley DR, Barker K, Simonite V, Beardshaw A. Delayed versus immediate exercises following surgery for breast cancer: a systematic review. Breast Cancer Res Treat. 2005;90:263–71.PubMedCrossRef
8.
go back to reference Kontos M, Petrou A, Prassas E, Tsigris C, Roy P, Trafalis D, et al. Pressure dressing in breast surgery: is this the solution for seroma formation? J BUON. 2008;13:65–7.PubMed Kontos M, Petrou A, Prassas E, Tsigris C, Roy P, Trafalis D, et al. Pressure dressing in breast surgery: is this the solution for seroma formation? J BUON. 2008;13:65–7.PubMed
9.
go back to reference Ruggiero R, Procaccini E, Piazza P, Docimo G, Iovino F, Antoniol G, et al. Effectiveness of fibrin glue in conjunction with collagen patches to reduce seroma formation after axillary lymphadenectomy for breast cancer. Am J Surg. 2008;196:170–4.PubMedCrossRef Ruggiero R, Procaccini E, Piazza P, Docimo G, Iovino F, Antoniol G, et al. Effectiveness of fibrin glue in conjunction with collagen patches to reduce seroma formation after axillary lymphadenectomy for breast cancer. Am J Surg. 2008;196:170–4.PubMedCrossRef
10.
go back to reference He XD, Guo ZH, Tian JH, Yang KH, Xie XD. Whether drainage should be used after surgery for breast cancer? A systematic review of randomized controlled trials. Med Oncol. 2011;28 Suppl 1:S22–30.PubMedCrossRef He XD, Guo ZH, Tian JH, Yang KH, Xie XD. Whether drainage should be used after surgery for breast cancer? A systematic review of randomized controlled trials. Med Oncol. 2011;28 Suppl 1:S22–30.PubMedCrossRef
11.
go back to reference Talbot ML, Magarey CJ. Reduced use of drains following axillary lymphadenectomy for breast cancer. ANZ J Surg. 2002;72:488–90.PubMedCrossRef Talbot ML, Magarey CJ. Reduced use of drains following axillary lymphadenectomy for breast cancer. ANZ J Surg. 2002;72:488–90.PubMedCrossRef
12.
go back to reference Moss JP. Historical and current perspectives on surgical drainage. Surg Gynecol Obstet. 1981;152:517–27.PubMed Moss JP. Historical and current perspectives on surgical drainage. Surg Gynecol Obstet. 1981;152:517–27.PubMed
13.
go back to reference Agrawal A, Ayantunde AA, Cheung KL. Concepts of seroma formation and prevention in breast cancer surgery. ANZ J Surg. 2006;76:1088–95.PubMedCrossRef Agrawal A, Ayantunde AA, Cheung KL. Concepts of seroma formation and prevention in breast cancer surgery. ANZ J Surg. 2006;76:1088–95.PubMedCrossRef
14.
go back to reference Saratzis A, Soumian S, Willetts R, Rastall S, Stonelake PS. Use of multiple drains after mastectomy is associated with more patient discomfort and longer postoperative stay. Clin Breast Cancer. 2009;9:243–6.PubMedCrossRef Saratzis A, Soumian S, Willetts R, Rastall S, Stonelake PS. Use of multiple drains after mastectomy is associated with more patient discomfort and longer postoperative stay. Clin Breast Cancer. 2009;9:243–6.PubMedCrossRef
15.
go back to reference Barton A, Blitz M, Callahan D, Yakimets W, Adams D, Dabbs K. Early removal of postmastectomy drains is not beneficial: results from a halted randomized controlled trial. Am J Surg. 2006;191:652–6.PubMedCrossRef Barton A, Blitz M, Callahan D, Yakimets W, Adams D, Dabbs K. Early removal of postmastectomy drains is not beneficial: results from a halted randomized controlled trial. Am J Surg. 2006;191:652–6.PubMedCrossRef
16.
go back to reference Gupta R, Pate K, Varshney S, Goddard J, Royle GT. A comparison of 5-day and 8-day drainage following mastectomy and axillary clearance. Eur J Surg Oncol. 2001;27:26–30.PubMedCrossRef Gupta R, Pate K, Varshney S, Goddard J, Royle GT. A comparison of 5-day and 8-day drainage following mastectomy and axillary clearance. Eur J Surg Oncol. 2001;27:26–30.PubMedCrossRef
17.
go back to reference Singletary SE, Allred C, Ashley P, Bassett LW, Berry D, Bland KI, et al. Revision of the American Joint Committee on Cancer staging system for breast cancer. J Clin Oncol. 2002;20:3628–36.PubMedCrossRef Singletary SE, Allred C, Ashley P, Bassett LW, Berry D, Bland KI, et al. Revision of the American Joint Committee on Cancer staging system for breast cancer. J Clin Oncol. 2002;20:3628–36.PubMedCrossRef
18.
go back to reference Iovino F, Auriemma PP, Ferraraccio F, Antoniol G, Barbarisi A. Preventing seroma formation after axillary dissection for breast cancer: a randomized clinical trial. Am J Surg. 2012;203:708–14.PubMedCrossRef Iovino F, Auriemma PP, Ferraraccio F, Antoniol G, Barbarisi A. Preventing seroma formation after axillary dissection for breast cancer: a randomized clinical trial. Am J Surg. 2012;203:708–14.PubMedCrossRef
19.
go back to reference Lin YP, Yin WJ, Yan TT, Zhou LH, Di GH, Wu J, et al. Risk factors for postoperative seromas in Chinese breast cancer patients. Chin Med J (Engl). 2011;124:1300–4. Lin YP, Yin WJ, Yan TT, Zhou LH, Di GH, Wu J, et al. Risk factors for postoperative seromas in Chinese breast cancer patients. Chin Med J (Engl). 2011;124:1300–4.
21.
go back to reference Li X, Kong X, Chen X, Zhang N, Jiang L, Ma T, et al. LAPTM4B allele *2 is associated with breast cancer susceptibility and prognosis. PLoS One. 2012;7:e44916.PubMedCentralPubMedCrossRef Li X, Kong X, Chen X, Zhang N, Jiang L, Ma T, et al. LAPTM4B allele *2 is associated with breast cancer susceptibility and prognosis. PLoS One. 2012;7:e44916.PubMedCentralPubMedCrossRef
22.
go back to reference Hormbrey E, Han C, Roberts A, McGrouther DA, Harris AL. The relationship of human wound vascular endothelial growth factor (VEGF) after breast cancer surgery to circulating VEGF and angiogenesis. Clin Cancer Res. 2003;9:4332–9.PubMed Hormbrey E, Han C, Roberts A, McGrouther DA, Harris AL. The relationship of human wound vascular endothelial growth factor (VEGF) after breast cancer surgery to circulating VEGF and angiogenesis. Clin Cancer Res. 2003;9:4332–9.PubMed
23.
go back to reference Wu FP, Hoekman K, Meijer S, Cuesta MA. VEGF and endostatin levels in wound fluid and plasma after breast surgery. Angiogenesis. 2003;6:255–7.PubMedCrossRef Wu FP, Hoekman K, Meijer S, Cuesta MA. VEGF and endostatin levels in wound fluid and plasma after breast surgery. Angiogenesis. 2003;6:255–7.PubMedCrossRef
24.
go back to reference Tagliabue E, Agresti R, Carcangiu ML, Ghirelli C, Morelli D, Campiglio M, et al. Role of HER2 in wound-induced breast carcinoma proliferation. Lancet. 2003;362:527–33.PubMedCrossRef Tagliabue E, Agresti R, Carcangiu ML, Ghirelli C, Morelli D, Campiglio M, et al. Role of HER2 in wound-induced breast carcinoma proliferation. Lancet. 2003;362:527–33.PubMedCrossRef
25.
go back to reference Fisher B, Gunduz N, Coyle J, Rudock C, Saffer E. Presence of a growth-stimulating factor in serum following primary tumor removal in mice. Cancer Res. 1989;49:1996–2001.PubMed Fisher B, Gunduz N, Coyle J, Rudock C, Saffer E. Presence of a growth-stimulating factor in serum following primary tumor removal in mice. Cancer Res. 1989;49:1996–2001.PubMed
26.
go back to reference Hofer SO, Shrayer D, Reichner JS, Hoekstra HJ, Wanebo HJ. Wound-induced tumor progression: a probable role in recurrence after tumor resection. Arch Surg. 1998;133:383–9.PubMedCrossRef Hofer SO, Shrayer D, Reichner JS, Hoekstra HJ, Wanebo HJ. Wound-induced tumor progression: a probable role in recurrence after tumor resection. Arch Surg. 1998;133:383–9.PubMedCrossRef
27.
go back to reference Barwell J, Campbell L, Watkins RM, Teasdale C. How long should suction drains stay in after breast surgery with axillary dissection? Ann R Coll Surg Engl. 1997;79:435–7.PubMedCentralPubMed Barwell J, Campbell L, Watkins RM, Teasdale C. How long should suction drains stay in after breast surgery with axillary dissection? Ann R Coll Surg Engl. 1997;79:435–7.PubMedCentralPubMed
28.
go back to reference Horgan K, Benson EA, Miller A, Robertson A. Early discharge with drain in situ following axillary lymphadenectomy for breast cancer. Breast. 2000;9:90–2.PubMedCrossRef Horgan K, Benson EA, Miller A, Robertson A. Early discharge with drain in situ following axillary lymphadenectomy for breast cancer. Breast. 2000;9:90–2.PubMedCrossRef
Metadata
Title
The volume and duration of wound drainage are independent prognostic factors for breast cancer
Authors
Yan Zhang
Hua Gao
Wei Gao
Publication date
01-04-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 4/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-1470-z

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