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Tumor Biology
Published in: Tumor Biology 2/2014

01-02-2014 | Research Article

Smoking and hOGG1 Ser326Cys polymorphism contribute to lung cancer risk: evidence from a meta-analysis

Authors: Zong-Bao Yin, Rui-Xi Hua, Jing-Hui Li, Chuan Sun, Jin-Hong Zhu, Xing Su, Chao Ji, Qun Xiang, Zhu-Ming Hua

Published in: Tumor Biology | Issue 2/2014

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Abstract

The human 8-oxoguanine DNA glycosylase (hOGG1) gene plays an important role in the repair of oxidatively damaged DNA base lesions and its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity and thus contributes to cancer susceptibility. Numerous studies have investigated the association between hOGG1 Ser326Cys polymorphism and lung cancer susceptibility; however, the conclusions are still inconclusive. We searched eligible publications from MEDLINE, EMBASE, and CBM and performed a meta-analysis to assess the associations between hOGG1 Ser326Cys polymorphism and lung cancer risk. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated to estimate risk associations, and false-positive report probability (FPRP) analysis was also carried out to evaluate significant findings. A total of 31 investigations with 10,220 cases and 12,284 controls were identified. When all studies were pooled, a significantly increased overall lung cancer risk was found (Cys/Cys vs. Ser/Ser: OR = 1.24, 95 % CI = 1.05–1.47, P = 0.013; recessive model: OR = 1.22, 95 % CI = 1.05–1.41, P = 0.008, and Cys vs. Ser: OR = 1.11, 95 % CI = 1.02–1.21, P = 0.022), and further stratification analysis showed that the association was stronger in Asians, never smokers, and more-cigarette takers. These results were confirmed by FPRP analysis. Despite some limitations, this meta-analysis provides solid evidence that hOGG1 Ser326Cys polymorphism may contribute to lung cancer risk, particularly for Asian populations, never smokers, and more-cigarette takers. Nevertheless, these findings warrant further validation in single large investigations.
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Metadata
Title
Smoking and hOGG1 Ser326Cys polymorphism contribute to lung cancer risk: evidence from a meta-analysis
Authors
Zong-Bao Yin
Rui-Xi Hua
Jing-Hui Li
Chuan Sun
Jin-Hong Zhu
Xing Su
Chao Ji
Qun Xiang
Zhu-Ming Hua
Publication date
01-02-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 2/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-1222-0

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