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Tumor Biology
Published in: Tumor Biology 4/2013

01-08-2013 | Review

Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets

Authors: Elin Hadler-Olsen, Jan-Olof Winberg, Lars Uhlin-Hansen

Published in: Tumor Biology | Issue 4/2013

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Abstract

Biomarkers are used as tools in cancer diagnostics and in treatment stratification. In most cancers, there are increased levels of one or several members of the matrix metalloproteinases (MMPs). This is a family of proteolytic enzymes that are involved in many phases of cancer progression, including angiogenesis, invasiveness, and metastasis. It has therefore been expected that MMPs could serve as both diagnostic and prognostic markers in cancer patients, but despite a huge number of studies, it has been difficult to establish MMPs as cancer biomarkers. In the present paper, we assess some of the challenges associated with MMP research as well as putative reasons for the conflicting data on the value of these enzymes as diagnostic and prognostic markers in cancer patients. We also review the prognostic value of a number of MMPs in patients with lung, colorectal, breast, and prostate cancers. The review also discusses MMPs as potential target molecules for therapeutic agents and new strategies for development of such drugs.
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Metadata
Title
Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
Authors
Elin Hadler-Olsen
Jan-Olof Winberg
Lars Uhlin-Hansen
Publication date
01-08-2013
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 4/2013
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-0842-8

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