Skip to main content
Top
Published in: Insights into Imaging 6/2011

Open Access 01-12-2011 | Original Article

Pineal cysts in children

Authors: V. Lacroix-Boudhrioua, A. Linglart, P. Y. Ancel, C. Falip, P. F. Bougnères, C. Adamsbaum

Published in: Insights into Imaging | Issue 6/2011

Login to get access

Abstract

Objective

To describe the prevalence and characteristics of pineal cysts found on MRI in children.

Methods

This is a retrospective monocentric study of all brain magnetic resonance imaging (MRI) examinations performed under the same technical conditions for checking the idiopathic nature of short stature (ISS group, n = 116) and for the investigation of central precocious puberty (CPP) over a 3-year period (n = 56). Dimensions, wall and septal thickness, number of locules, signal intensity, and the presence of a solid component were analysed. Ten of 19 cysts were re-evaluated (follow-up interval 4–28 months). The prevalence of the pineal cysts was compared between the two groups using χ2 and Fisher’s exact tests, and a significance threshold of p < 0.05.

Results

The prevalence of cysts was comparable in the two groups, CPP (10.7%) and ISS (11.2%). Cyst characteristics were similar in the two groups and 74% had thin septations. None of the cysts changed on follow-up. None of the children with pineal cysts exhibited neurological signs.

Conclusion

Benign pineal cysts are a common finding in young children. High-resolution MRI demonstrates that these cysts are often septated. This pattern is a normal variant and does not require follow-up MR imaging or IV contrast media.
Literature
1.
go back to reference Hasegawa A, Ohtsubo K, Mori W (1987) Pineal gland in old age; quantitative and qualitative morphological study of 168 human autopsy cases. Brain Res 409:343–349PubMedCrossRef Hasegawa A, Ohtsubo K, Mori W (1987) Pineal gland in old age; quantitative and qualitative morphological study of 168 human autopsy cases. Brain Res 409:343–349PubMedCrossRef
2.
go back to reference Al-Holou WN, Maher CO, Muraszko KM et al (2010) The natural history of the pineal cysts in children and young adults. J Neurosurg Pediatr 5:162–166PubMedCrossRef Al-Holou WN, Maher CO, Muraszko KM et al (2010) The natural history of the pineal cysts in children and young adults. J Neurosurg Pediatr 5:162–166PubMedCrossRef
3.
go back to reference Barboriak DP, Lee L, Provenzale JM (2001) Serial MR imaging of pineal cysts: implications for natural history and follow-up. AJR Am J Roentgenol 176:737–743PubMedCrossRef Barboriak DP, Lee L, Provenzale JM (2001) Serial MR imaging of pineal cysts: implications for natural history and follow-up. AJR Am J Roentgenol 176:737–743PubMedCrossRef
4.
go back to reference Cauley KA, Linell GJ, Braff SP et al (2009) Serial follow-up MRI of indeterminate cystic lesions of the pineal region: experience of a rural tertiary care referral center. AJR Am J Roentgenol 193:533–537PubMedCrossRef Cauley KA, Linell GJ, Braff SP et al (2009) Serial follow-up MRI of indeterminate cystic lesions of the pineal region: experience of a rural tertiary care referral center. AJR Am J Roentgenol 193:533–537PubMedCrossRef
5.
go back to reference Mandera M, Marcol W, Bierzynska-Macyszyn G et al (2003) Pineal cysts in childhood. Childs Nerv Syst 19:750–755PubMedCrossRef Mandera M, Marcol W, Bierzynska-Macyszyn G et al (2003) Pineal cysts in childhood. Childs Nerv Syst 19:750–755PubMedCrossRef
6.
go back to reference Petitcolin V, Garcier JM, Mohammedi R et al (2002) Prévalence et morphologie des kystes épiphysaires: à propos de 1844 IRM hypophysaires. J Radiol 83:141–145PubMed Petitcolin V, Garcier JM, Mohammedi R et al (2002) Prévalence et morphologie des kystes épiphysaires: à propos de 1844 IRM hypophysaires. J Radiol 83:141–145PubMed
7.
go back to reference Sawamura Y, Ikeda J, Ozawa M et al (1995) Magnetic resonance images reveal a high incidence of asymptomatic pineal cysts in young women. Neurosurgery 37:11–15PubMedCrossRef Sawamura Y, Ikeda J, Ozawa M et al (1995) Magnetic resonance images reveal a high incidence of asymptomatic pineal cysts in young women. Neurosurgery 37:11–15PubMedCrossRef
8.
go back to reference Sener RN (1995) The pineal gland: a comparative MR imaging study in children and adults with respect to normal anatomical variations and pineal cysts. Pediatr Radiol 25:245–248PubMedCrossRef Sener RN (1995) The pineal gland: a comparative MR imaging study in children and adults with respect to normal anatomical variations and pineal cysts. Pediatr Radiol 25:245–248PubMedCrossRef
9.
go back to reference Pu Y, Mahankali S, Hou J et al (2007) High prevalence of pineal cysts in healthy adults demonstrated by high-resolution, non contrast brain MR imaging. AJNR Am J Neuroradiol 28:1706–1709PubMedCrossRef Pu Y, Mahankali S, Hou J et al (2007) High prevalence of pineal cysts in healthy adults demonstrated by high-resolution, non contrast brain MR imaging. AJNR Am J Neuroradiol 28:1706–1709PubMedCrossRef
10.
go back to reference Barkovich AJ (2005) Pediatric Neuroimaging, 4th edn. Lippincott Williams & Wilkins, Philadelphia Barkovich AJ (2005) Pediatric Neuroimaging, 4th edn. Lippincott Williams & Wilkins, Philadelphia
11.
go back to reference Jinkins JR, Xiong L, Reiter RJ (1995) The midline pineal “eye”: MR and CT characteristics of the pineal gland with and without benign cyst formation. J Pineal Res 19:64–71PubMedCrossRef Jinkins JR, Xiong L, Reiter RJ (1995) The midline pineal “eye”: MR and CT characteristics of the pineal gland with and without benign cyst formation. J Pineal Res 19:64–71PubMedCrossRef
12.
go back to reference Osborn AG (2004) Diagnostic imaging: brain. Amirsys, Salt Lake City, pp 132–135, pp 26–29 Osborn AG (2004) Diagnostic imaging: brain. Amirsys, Salt Lake City, pp 132–135, pp 26–29
13.
go back to reference Golzarian J, Baleriaux D, Bank WO et al (1993) Pineal cyst: normal or pathological? Neuroradiology 35:251–253PubMedCrossRef Golzarian J, Baleriaux D, Bank WO et al (1993) Pineal cyst: normal or pathological? Neuroradiology 35:251–253PubMedCrossRef
14.
15.
go back to reference Al-Holou WN, Hugh JL, Muraszko KM et al (2009) Prevalence of pineal cysts in children and young adults. J Neurosurg Pediatr 4:230–236PubMedCrossRef Al-Holou WN, Hugh JL, Muraszko KM et al (2009) Prevalence of pineal cysts in children and young adults. J Neurosurg Pediatr 4:230–236PubMedCrossRef
16.
go back to reference Osborn AG, Preece MT (2006) Intracranial cysts: radiologic-pathologic correlation and imaging approach. Radiology 239:650–664PubMedCrossRef Osborn AG, Preece MT (2006) Intracranial cysts: radiologic-pathologic correlation and imaging approach. Radiology 239:650–664PubMedCrossRef
17.
go back to reference Pastel DA, Mamourian AC, Duhaime AC (2009) Internal structure in pineal cysts on high-resolution magnetic resonance imaging: not a sign of malignancy. J Neurosurg Pediatr 4:81–84PubMedCrossRef Pastel DA, Mamourian AC, Duhaime AC (2009) Internal structure in pineal cysts on high-resolution magnetic resonance imaging: not a sign of malignancy. J Neurosurg Pediatr 4:81–84PubMedCrossRef
18.
go back to reference Inoue Y, Saiwai S, Miyamoto T et al (1994) Enhanced high-resolution sagittal MRI of normal pineal glands. J Comput Assist Tomogr 18:182–186PubMedCrossRef Inoue Y, Saiwai S, Miyamoto T et al (1994) Enhanced high-resolution sagittal MRI of normal pineal glands. J Comput Assist Tomogr 18:182–186PubMedCrossRef
19.
go back to reference Patel AJ, Fuller GN, Wildrick DM et al (2005) Pineal cyst apoplexy: case report and review of the literature. Neurosurgery 57:1066CrossRef Patel AJ, Fuller GN, Wildrick DM et al (2005) Pineal cyst apoplexy: case report and review of the literature. Neurosurgery 57:1066CrossRef
20.
go back to reference Kjos BO, Brant-Zawadzki M, Kucharczyk W et al (1985) Cystic intracranial lesions: magnetic resonance imaging. Radiology 155:363–369PubMedCrossRef Kjos BO, Brant-Zawadzki M, Kucharczyk W et al (1985) Cystic intracranial lesions: magnetic resonance imaging. Radiology 155:363–369PubMedCrossRef
21.
go back to reference Fleege MA, Miller GM, Fletcher GP et al (1994) Benign glial cysts of the pineal gland: unusual imaging characteristics with histologic correlation. AJNR Am J Neuroradiol 15:161–166PubMed Fleege MA, Miller GM, Fletcher GP et al (1994) Benign glial cysts of the pineal gland: unusual imaging characteristics with histologic correlation. AJNR Am J Neuroradiol 15:161–166PubMed
22.
go back to reference Mamourian AC, Yarnell T (1991) Enhancement of pineal cysts on MR images. AJNR Am J Neuroradiol 12:773–774PubMed Mamourian AC, Yarnell T (1991) Enhancement of pineal cysts on MR images. AJNR Am J Neuroradiol 12:773–774PubMed
23.
go back to reference Fain JS, Tomlinson FH, Scheithauer BW et al (1994) Symptomatic glial cysts of the pineal gland. J Neurosurg 80:454–460PubMedCrossRef Fain JS, Tomlinson FH, Scheithauer BW et al (1994) Symptomatic glial cysts of the pineal gland. J Neurosurg 80:454–460PubMedCrossRef
24.
25.
go back to reference Fakhran S, Escott EJ (2008) Pineocytoma mimicking a pineal cyst on imaging: true diagnostic dilemma or a case of incomplete imaging? AJNR Am J Neuroradiol 29:159–163PubMedCrossRef Fakhran S, Escott EJ (2008) Pineocytoma mimicking a pineal cyst on imaging: true diagnostic dilemma or a case of incomplete imaging? AJNR Am J Neuroradiol 29:159–163PubMedCrossRef
26.
go back to reference Kim BS, Kim DK, Park SH (2009) Pineal parenchymal tumor of intermediate differentiation showing malignant progression at relapse. Neuropathology 29:602–608PubMedCrossRef Kim BS, Kim DK, Park SH (2009) Pineal parenchymal tumor of intermediate differentiation showing malignant progression at relapse. Neuropathology 29:602–608PubMedCrossRef
Metadata
Title
Pineal cysts in children
Authors
V. Lacroix-Boudhrioua
A. Linglart
P. Y. Ancel
C. Falip
P. F. Bougnères
C. Adamsbaum
Publication date
01-12-2011
Publisher
Springer Berlin Heidelberg
Published in
Insights into Imaging / Issue 6/2011
Electronic ISSN: 1869-4101
DOI
https://doi.org/10.1007/s13244-011-0117-0

Other articles of this Issue 6/2011

Insights into Imaging 6/2011 Go to the issue