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Published in: The Journal of Obstetrics and Gynecology of India 4/2018

01-08-2018 | Invited Review Article

Ovulation Induction for the General Gynecologist

Authors: Steven R. Lindheim, Tanya L. Glenn, Megan C. Smith, Pascal Gagneux

Published in: The Journal of Obstetrics and Gynecology of India | Issue 4/2018

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Abstract

The practice of ovulation induction often falls to the reproductive endocrinology and infertility specialist. However, attitudes toward the evaluation and treatment of infertility has shifted among general obstetrician-gynecologists (OB-GYN). This review discusses the underlying scientific basis of anovulation and clinical guidelines regarding the use of different medications for the purpose of promoting follicular recruitment and ovulation for the general OB-GYN.
Literature
1.
go back to reference Thoma ME, McLain AC, Louis JF, et al. The prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach. Fertil Steril. 2013;99(5):1324–1331.e1.CrossRefPubMedPubMedCentral Thoma ME, McLain AC, Louis JF, et al. The prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach. Fertil Steril. 2013;99(5):1324–1331.e1.CrossRefPubMedPubMedCentral
2.
go back to reference Lindsay TJ, Vitrikas KR. Evaluation and treatment of infertility. Am Fam Physician. 2015;91(5):308–14.PubMed Lindsay TJ, Vitrikas KR. Evaluation and treatment of infertility. Am Fam Physician. 2015;91(5):308–14.PubMed
3.
go back to reference Amer SA, Li TC, Metwally M, et al. Randomized controlled trial comparing laparoscopic ovarian diathermy with clomiphene citrate as a first-line method of ovulation induction in women with polycystic ovary syndrome. Hum Reprod. 2009;24(1):219–25.CrossRefPubMed Amer SA, Li TC, Metwally M, et al. Randomized controlled trial comparing laparoscopic ovarian diathermy with clomiphene citrate as a first-line method of ovulation induction in women with polycystic ovary syndrome. Hum Reprod. 2009;24(1):219–25.CrossRefPubMed
4.
go back to reference Eldein HN. Family physicians’ attitude and practice of infertility management at primary care—Suez Canal University, Egypt. Pan Afr Med J 2013;15:106.PubMed Eldein HN. Family physicians’ attitude and practice of infertility management at primary care—Suez Canal University, Egypt. Pan Afr Med J 2013;15:106.PubMed
5.
go back to reference National Collaborating Centre for Women’s and Children’s Health (UK). Ovulation disorders. In: Fertility: Assessment and treatment for people with fertility problems. London: Royal College of Obstetricians & Gynaecologists; 2013. National Collaborating Centre for Women’s and Children’s Health (UK). Ovulation disorders. In: Fertility: Assessment and treatment for people with fertility problems. London: Royal College of Obstetricians & Gynaecologists; 2013.
6.
go back to reference Mesiano S, Jones EE. Chapter 55: The female reproductive system. In: Boron WF, Boulpaep EL, editors. Medical physiology. 3rd ed. Philadelphia: Elsevier; 2017. Mesiano S, Jones EE. Chapter 55: The female reproductive system. In: Boron WF, Boulpaep EL, editors. Medical physiology. 3rd ed. Philadelphia: Elsevier; 2017.
7.
go back to reference Speroff L, Fritz M, editors. Clinical gynecologic endocrinology and infertility. 8th ed. Philadelphia: Lippincott, WIlliams & Wilkins; 2011. Speroff L, Fritz M, editors. Clinical gynecologic endocrinology and infertility. 8th ed. Philadelphia: Lippincott, WIlliams & Wilkins; 2011.
8.
go back to reference Bao B, Garverick HA. Expression of steroidogenic enzyme and gonadotropin receptor genes in bovine follicles during ovarian follicular waves: a review. J Anim Sci. 1998;76(7):1903–21.CrossRefPubMed Bao B, Garverick HA. Expression of steroidogenic enzyme and gonadotropin receptor genes in bovine follicles during ovarian follicular waves: a review. J Anim Sci. 1998;76(7):1903–21.CrossRefPubMed
9.
go back to reference Roy SK, Treacy BJ. Isolation and long-term culture of human preantral follicles**Supported by grant HD 18165 (to S.K.R.) from the national institutes of health, Bethesda, Maryland. Fertil Steril. 1993;59(4):783–90.CrossRefPubMed Roy SK, Treacy BJ. Isolation and long-term culture of human preantral follicles**Supported by grant HD 18165 (to S.K.R.) from the national institutes of health, Bethesda, Maryland. Fertil Steril. 1993;59(4):783–90.CrossRefPubMed
10.
go back to reference Martinez AM, Lindheim SR. Induction of ovulation. In: Falcone T, Hurd WW, editors. Clinical reproductive medicine and surgery: a practical guide. 2nd ed. London: Springer; 2013. Martinez AM, Lindheim SR. Induction of ovulation. In: Falcone T, Hurd WW, editors. Clinical reproductive medicine and surgery: a practical guide. 2nd ed. London: Springer; 2013.
11.
go back to reference Brown JB. Pituitary control of ovarian function–concepts derived from gonadotrophin therapy. Aust N Z J Obstet Gynaecol. 1978;18(1):46–54.CrossRefPubMed Brown JB. Pituitary control of ovarian function–concepts derived from gonadotrophin therapy. Aust N Z J Obstet Gynaecol. 1978;18(1):46–54.CrossRefPubMed
12.
go back to reference Niswender GD, Juengel JL, Silva PJ, et al. Mechanisms controlling the function and life span of the corpus luteum. Physiol Rev. 2000;80(1):1–29.CrossRefPubMed Niswender GD, Juengel JL, Silva PJ, et al. Mechanisms controlling the function and life span of the corpus luteum. Physiol Rev. 2000;80(1):1–29.CrossRefPubMed
13.
go back to reference Deveci CD, Demir B, Sengul O, et al. Clomiphene citrate ‘stair-step’ protocol vs. traditional protocol in patients with polycystic ovary syndrome: a randomized controlled trial. Arch Gynecol Obstet. 2015;291(1):179–84.CrossRefPubMed Deveci CD, Demir B, Sengul O, et al. Clomiphene citrate ‘stair-step’ protocol vs. traditional protocol in patients with polycystic ovary syndrome: a randomized controlled trial. Arch Gynecol Obstet. 2015;291(1):179–84.CrossRefPubMed
14.
go back to reference Dong X, Zheng Y, Liao X, et al. Does progesterone-induced endometrial withdrawal bleed before ovulation induction have negative effects on IUI outcomes in patients with polycystic ovary syndrome? Int J Clin Exp Pathol. 2013;6(6):1157–63.PubMedPubMedCentral Dong X, Zheng Y, Liao X, et al. Does progesterone-induced endometrial withdrawal bleed before ovulation induction have negative effects on IUI outcomes in patients with polycystic ovary syndrome? Int J Clin Exp Pathol. 2013;6(6):1157–63.PubMedPubMedCentral
15.
go back to reference Moy I, Ekpo G. Clomiphene citrate use for ovulation induction: When, why, and how? Contemporary OB/GYN 2011. Moy I, Ekpo G. Clomiphene citrate use for ovulation induction: When, why, and how? Contemporary OB/GYN 2011.
16.
go back to reference Jones T, Gualtieri M, Bruno-Gaston J, et al. Evaluation of clomiphene citrate stair-step protocol for ovulation induction. Fertil Steril. 2014;102(3):e138.CrossRef Jones T, Gualtieri M, Bruno-Gaston J, et al. Evaluation of clomiphene citrate stair-step protocol for ovulation induction. Fertil Steril. 2014;102(3):e138.CrossRef
17.
go back to reference Diamond MP, Kruger M, Santoro N, et al. Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome. Obstet Gynecol. 2012;119(5):902–8.CrossRefPubMedPubMedCentral Diamond MP, Kruger M, Santoro N, et al. Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome. Obstet Gynecol. 2012;119(5):902–8.CrossRefPubMedPubMedCentral
18.
go back to reference Athaullah N, Proctor M, Johnson NP. Oral versus injectable ovulation induction agents for unexplained subfertility. Cochrane Database Syst Rev. 2002;3:CD003052. Athaullah N, Proctor M, Johnson NP. Oral versus injectable ovulation induction agents for unexplained subfertility. Cochrane Database Syst Rev. 2002;3:CD003052.
19.
go back to reference Sallam HN, Abdel-Bak M, Sallam NH. Does ovulation induction increase the risk of gynecological cancer? Facts Views Vis Obgyn. 2013;5(4):265–73.PubMedPubMedCentral Sallam HN, Abdel-Bak M, Sallam NH. Does ovulation induction increase the risk of gynecological cancer? Facts Views Vis Obgyn. 2013;5(4):265–73.PubMedPubMedCentral
20.
go back to reference Seyedoshohadaei F, Zandvakily F, Shahgeibi S. Comparison of the effectiveness of clomiphene citrate, tamoxifen and letrozole in ovulation induction in infertility due to isolated unovulation. Iran J Reprod Med. 2012;10(6):531–6.PubMedPubMedCentral Seyedoshohadaei F, Zandvakily F, Shahgeibi S. Comparison of the effectiveness of clomiphene citrate, tamoxifen and letrozole in ovulation induction in infertility due to isolated unovulation. Iran J Reprod Med. 2012;10(6):531–6.PubMedPubMedCentral
21.
go back to reference Legro RS, Brzyski RG, Diamond MP, et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med. 2014;371(2):119–29.CrossRefPubMedPubMedCentral Legro RS, Brzyski RG, Diamond MP, et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med. 2014;371(2):119–29.CrossRefPubMedPubMedCentral
22.
go back to reference Zakherah MS, Nasr A, El Saman AM, et al. Clomiphene citrate plus tamoxifen versus laparoscopic ovarian drilling in women with clomiphene-resistant polycystic ovary syndrome. Int J Gynaecol Obstet. 2010;108(3):240–3.CrossRefPubMed Zakherah MS, Nasr A, El Saman AM, et al. Clomiphene citrate plus tamoxifen versus laparoscopic ovarian drilling in women with clomiphene-resistant polycystic ovary syndrome. Int J Gynaecol Obstet. 2010;108(3):240–3.CrossRefPubMed
23.
go back to reference de Paula Guedes Neto E, Savaris RF, von Eye Corleta H, et al. Prospective, randomized comparison between raloxifene and clomiphene citrate for ovulation induction in polycystic ovary syndrome. Fertil Steril. 2011;96(3):769–73.CrossRefPubMed de Paula Guedes Neto E, Savaris RF, von Eye Corleta H, et al. Prospective, randomized comparison between raloxifene and clomiphene citrate for ovulation induction in polycystic ovary syndrome. Fertil Steril. 2011;96(3):769–73.CrossRefPubMed
24.
go back to reference Dhaliwal LK, Suri V, Gupta KR, et al. Tamoxifen: an alternative to clomiphene in women with polycystic ovary syndrome. J Hum Reprod Sci. 2011;4(2):76–9.CrossRefPubMedPubMedCentral Dhaliwal LK, Suri V, Gupta KR, et al. Tamoxifen: an alternative to clomiphene in women with polycystic ovary syndrome. J Hum Reprod Sci. 2011;4(2):76–9.CrossRefPubMedPubMedCentral
25.
go back to reference El-Gharib MN, Mahfouz AE, Farahat MA. Comparison of letrozole versus tamoxifen effects in clomiphen citrate resistant women with polycystic ovarian syndrome. J Reprod Infertil. 2015;16(1):30–5.PubMedPubMedCentral El-Gharib MN, Mahfouz AE, Farahat MA. Comparison of letrozole versus tamoxifen effects in clomiphen citrate resistant women with polycystic ovarian syndrome. J Reprod Infertil. 2015;16(1):30–5.PubMedPubMedCentral
27.
go back to reference Finn RS, Crown JP, Lang I, et al. The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol. 2015;16(1):25–35.CrossRefPubMed Finn RS, Crown JP, Lang I, et al. The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol. 2015;16(1):25–35.CrossRefPubMed
28.
go back to reference Roque M, Tostes AC, Valle M, et al. Letrozole versus clomiphene citrate in polycystic ovary syndrome: systematic review and meta-analysis. Gynecol Endocrinol. 2015;31(12):917–21.CrossRefPubMed Roque M, Tostes AC, Valle M, et al. Letrozole versus clomiphene citrate in polycystic ovary syndrome: systematic review and meta-analysis. Gynecol Endocrinol. 2015;31(12):917–21.CrossRefPubMed
29.
go back to reference Penzias A, Bendikson K, Butts S, et al. Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): A guideline. Fertil Steril. 2017;108(3):426–41.CrossRef Penzias A, Bendikson K, Butts S, et al. Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): A guideline. Fertil Steril. 2017;108(3):426–41.CrossRef
30.
go back to reference Tock L, Carneiro G, Pereira AZ, et al. Adrenocortical production is associated with higher levels of luteinizing hormone in nonobese women with polycystic ovary syndrome. Int J Endocrinol. 2014;2014:620605.CrossRefPubMedPubMedCentral Tock L, Carneiro G, Pereira AZ, et al. Adrenocortical production is associated with higher levels of luteinizing hormone in nonobese women with polycystic ovary syndrome. Int J Endocrinol. 2014;2014:620605.CrossRefPubMedPubMedCentral
31.
go back to reference Morin-Papunen L, Rantala AS, Unkila-Kallio L, et al. Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial. J Clin Endocrinol Metab. 2012;97(5):1492–500.CrossRefPubMed Morin-Papunen L, Rantala AS, Unkila-Kallio L, et al. Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial. J Clin Endocrinol Metab. 2012;97(5):1492–500.CrossRefPubMed
33.
go back to reference Sohrabvand F, Ansari S, Bagheri M. Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. Hum Reprod. 2006;21(6):1432–5.CrossRefPubMed Sohrabvand F, Ansari S, Bagheri M. Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. Hum Reprod. 2006;21(6):1432–5.CrossRefPubMed
34.
go back to reference Melo AS, Ferriani RA, Navarro PA. Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice. Clinics (Sao Paulo). 2015;70(11):765–9.CrossRef Melo AS, Ferriani RA, Navarro PA. Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice. Clinics (Sao Paulo). 2015;70(11):765–9.CrossRef
35.
go back to reference Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Consensus on infertility treatment related to polycystic ovary syndrome. Hum Reprod. 2008;23(3):462–77.CrossRef Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Consensus on infertility treatment related to polycystic ovary syndrome. Hum Reprod. 2008;23(3):462–77.CrossRef
37.
go back to reference Practice Committee of American Society for Reproductive Medicine. Use of exogenous gonadotropins in anovulatory women: a technical bulletin. Fertil Steril. 2008;90(5 Suppl):S7–12. Practice Committee of American Society for Reproductive Medicine. Use of exogenous gonadotropins in anovulatory women: a technical bulletin. Fertil Steril. 2008;90(5 Suppl):S7–12.
38.
39.
go back to reference Kawwass JF, Loucks TL, Berga SL. An algorithm for treatment of infertile women with polycystic ovary syndrome. Middle East Fertil Soc J. 2010;15(4):231–9.CrossRef Kawwass JF, Loucks TL, Berga SL. An algorithm for treatment of infertile women with polycystic ovary syndrome. Middle East Fertil Soc J. 2010;15(4):231–9.CrossRef
40.
go back to reference Palshetkar N, Roongta N. Protocols for ovulation induction. In: Mumbai Obstetric and Gynecological Society; 2011. Palshetkar N, Roongta N. Protocols for ovulation induction. In: Mumbai Obstetric and Gynecological Society; 2011.
41.
go back to reference Fauser BC, Van Heusden AM. Manipulation of human ovarian function: physiological concepts and clinical consequences. Endocr Rev. 1997;18(1):71–106.PubMed Fauser BC, Van Heusden AM. Manipulation of human ovarian function: physiological concepts and clinical consequences. Endocr Rev. 1997;18(1):71–106.PubMed
42.
go back to reference Tarlatzis BC, Fauser BC, Kolibianakis EM, et al. GnRH antagonists in ovarian stimulation for IVF. Hum Reprod Update. 2006;12(4):333–40.CrossRefPubMed Tarlatzis BC, Fauser BC, Kolibianakis EM, et al. GnRH antagonists in ovarian stimulation for IVF. Hum Reprod Update. 2006;12(4):333–40.CrossRefPubMed
43.
go back to reference Birch Petersen K, Pedersen NG, Pedersen AT, et al. Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction. Reprod Biomed Online. 2016;32(6):563–83.CrossRefPubMed Birch Petersen K, Pedersen NG, Pedersen AT, et al. Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction. Reprod Biomed Online. 2016;32(6):563–83.CrossRefPubMed
44.
go back to reference Casper RF, Mitwally MF. Use of the aromatase inhibitor letrozole for ovulation induction in women with polycystic ovarian syndrome. Clin Obstet Gynecol. 2011;54(4):685–95.CrossRefPubMed Casper RF, Mitwally MF. Use of the aromatase inhibitor letrozole for ovulation induction in women with polycystic ovarian syndrome. Clin Obstet Gynecol. 2011;54(4):685–95.CrossRefPubMed
45.
go back to reference Lee Y, Kim Y, Chang J, et al. Changes in oral mucosal MUCI expression and salivary hormones throughout the menstrual cycle. Oral Disease. 2015;21(962):968. Lee Y, Kim Y, Chang J, et al. Changes in oral mucosal MUCI expression and salivary hormones throughout the menstrual cycle. Oral Disease. 2015;21(962):968.
46.
go back to reference Fiedler K, Ezcurra D. Predicting and preventing ovarian hyperstimulation syndrome (OHSS): the need for individualized not standardized treatment. Reprod Biol Endocrinol. 2012;10(1):32.CrossRefPubMedPubMedCentral Fiedler K, Ezcurra D. Predicting and preventing ovarian hyperstimulation syndrome (OHSS): the need for individualized not standardized treatment. Reprod Biol Endocrinol. 2012;10(1):32.CrossRefPubMedPubMedCentral
47.
go back to reference Al-Inany H, Youssef MA, Ayeleke RO, et al. Gonadotrophin-releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst Rev. 2016;4:CD001750.PubMed Al-Inany H, Youssef MA, Ayeleke RO, et al. Gonadotrophin-releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst Rev. 2016;4:CD001750.PubMed
48.
go back to reference Practice Committee of the American Society for Reproductive Medicine. Fertility drugs and cancer: a guideline. Fertil Steril. 2016;106(7):1617–26.CrossRef Practice Committee of the American Society for Reproductive Medicine. Fertility drugs and cancer: a guideline. Fertil Steril. 2016;106(7):1617–26.CrossRef
49.
go back to reference Rizzuto I, Behrens RF, Smith LA. Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility. Cochrane Database Syst Rev. 2013;8:CD008215. Rizzuto I, Behrens RF, Smith LA. Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility. Cochrane Database Syst Rev. 2013;8:CD008215.
50.
go back to reference Fernandez H, Morin-Surruca M, Torre A, et al. Ovarian drilling for surgical treatment of polycystic ovarian syndrome: a comprehensive review. Reprod Biomed Online. 2011;22(6):556–68.CrossRefPubMed Fernandez H, Morin-Surruca M, Torre A, et al. Ovarian drilling for surgical treatment of polycystic ovarian syndrome: a comprehensive review. Reprod Biomed Online. 2011;22(6):556–68.CrossRefPubMed
51.
go back to reference Farquhar C, Brown J, Marjoribanks J, Vandekerckhove P. Laparoscopic drilling by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome. Cochrane Database Syst Rev. 2012;6:CD001122. Farquhar C, Brown J, Marjoribanks J, Vandekerckhove P. Laparoscopic drilling by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome. Cochrane Database Syst Rev. 2012;6:CD001122.
52.
go back to reference Practice Committee of the American Society for Reproductive Medicine. Use of clomiphene citrate in infertile women: a committee opinion. Fertil Steril. 2013;100(2):341–8.CrossRef Practice Committee of the American Society for Reproductive Medicine. Use of clomiphene citrate in infertile women: a committee opinion. Fertil Steril. 2013;100(2):341–8.CrossRef
53.
go back to reference Fortune JE. Ovarian follicular growth and development in mammals. Biol Reprod. 1994;50(2):225–32.CrossRefPubMed Fortune JE. Ovarian follicular growth and development in mammals. Biol Reprod. 1994;50(2):225–32.CrossRefPubMed
54.
go back to reference Chizen DR, Pierson R. Transvaginal ultrasonography and female infertility. In: The Global Library of Women’s Medicine; 2010. Chizen DR, Pierson R. Transvaginal ultrasonography and female infertility. In: The Global Library of Women’s Medicine; 2010.
55.
go back to reference Su H, Yi Y, Wei T, et al. Detection of ovulation, a review of currently available methods. Bioeng Transl Med. 2017;2(3):238–46.PubMedPubMedCentral Su H, Yi Y, Wei T, et al. Detection of ovulation, a review of currently available methods. Bioeng Transl Med. 2017;2(3):238–46.PubMedPubMedCentral
56.
go back to reference Tourville TW, Shultz SJ, Vacek PM, et al. Evaluation of an algorithm to predict menstrual-cycle phase at the time of injury. J Athl Train. 2016;51(1):47–56.CrossRefPubMedPubMedCentral Tourville TW, Shultz SJ, Vacek PM, et al. Evaluation of an algorithm to predict menstrual-cycle phase at the time of injury. J Athl Train. 2016;51(1):47–56.CrossRefPubMedPubMedCentral
57.
go back to reference Hassan A, Shehata N, Wahba A. Cost effectiveness of letrozole and purified urinary FSH in treating women with clomiphene citrate-resistant polycystic ovarian syndrome: a randomized controlled trial. Hum Fertil (Camb). 2017;20(1):37–42.CrossRef Hassan A, Shehata N, Wahba A. Cost effectiveness of letrozole and purified urinary FSH in treating women with clomiphene citrate-resistant polycystic ovarian syndrome: a randomized controlled trial. Hum Fertil (Camb). 2017;20(1):37–42.CrossRef
59.
go back to reference Kamath MS, Maheshwari A, Bhattacharya S, Lor KY, Gibreel A. Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilisation. Cochrane Database Syst Rev. 2017;1:CD008528. Kamath MS, Maheshwari A, Bhattacharya S, Lor KY, Gibreel A. Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilisation. Cochrane Database Syst Rev. 2017;1:CD008528.
61.
go back to reference Suginami H, Kitagawa H, Nakahashi N, et al. A clomiphene citrate and tamoxifen citrate combination therapy: a novel therapy for ovulation induction. Fertil Steril. 1993;59(5):976–9.CrossRefPubMed Suginami H, Kitagawa H, Nakahashi N, et al. A clomiphene citrate and tamoxifen citrate combination therapy: a novel therapy for ovulation induction. Fertil Steril. 1993;59(5):976–9.CrossRefPubMed
62.
go back to reference Franik S, Kremer J, Nelen W, Farquhar C. Aromatase inhibitors for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2014;24(2):CD010287. Franik S, Kremer J, Nelen W, Farquhar C. Aromatase inhibitors for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2014;24(2):CD010287.
64.
go back to reference Fabian CJ. The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer. Int J Clin Pract. 2007;61(12):2051–63.CrossRefPubMedPubMedCentral Fabian CJ. The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer. Int J Clin Pract. 2007;61(12):2051–63.CrossRefPubMedPubMedCentral
65.
go back to reference He Q, Liang L, Zhang C, et al. Effects of different doses of letrozole on the incidence of early-onset ovarian hyperstimulation syndrome after oocyte retrieval. Syst Biol Reprod Med. 2014;60(6):355–60.CrossRefPubMed He Q, Liang L, Zhang C, et al. Effects of different doses of letrozole on the incidence of early-onset ovarian hyperstimulation syndrome after oocyte retrieval. Syst Biol Reprod Med. 2014;60(6):355–60.CrossRefPubMed
66.
go back to reference Misso ML, Costello MF, Garrubba M, et al. Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2013;19(1):2–11.CrossRefPubMed Misso ML, Costello MF, Garrubba M, et al. Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2013;19(1):2–11.CrossRefPubMed
68.
go back to reference Barbieri RL. Clomiphene versus metformin for ovulation induction in polycystic ovary syndrome: the winner is. J Clin Endocrinol Metab. 2007;92(9):3399–401.CrossRefPubMed Barbieri RL. Clomiphene versus metformin for ovulation induction in polycystic ovary syndrome: the winner is. J Clin Endocrinol Metab. 2007;92(9):3399–401.CrossRefPubMed
69.
go back to reference Cedrin-Durnerin I, Massin N, Galey-Fontaine J, et al. Timing of FSH administration for ovarian stimulation in normo-ovulatory women: comparison of an early or a mid follicular phase initiation of a short-term treatment. Hum Reprod. 2006;21(11):2941–7.CrossRefPubMed Cedrin-Durnerin I, Massin N, Galey-Fontaine J, et al. Timing of FSH administration for ovarian stimulation in normo-ovulatory women: comparison of an early or a mid follicular phase initiation of a short-term treatment. Hum Reprod. 2006;21(11):2941–7.CrossRefPubMed
Metadata
Title
Ovulation Induction for the General Gynecologist
Authors
Steven R. Lindheim
Tanya L. Glenn
Megan C. Smith
Pascal Gagneux
Publication date
01-08-2018
Publisher
Springer India
Published in
The Journal of Obstetrics and Gynecology of India / Issue 4/2018
Print ISSN: 0971-9202
Electronic ISSN: 0975-6434
DOI
https://doi.org/10.1007/s13224-018-1130-8

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