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The Journal of Obstetrics and Gynecology of India
Published in: The Journal of Obstetrics and Gynecology of India 4/2013

01-08-2013 | Original Article

The Efficacy and Safety of Neoadjuvant Chemotherapy in Treatment of Locally Advanced Carcinoma Cervix

Authors: Uma Singh, Neetu Ahirwar, Anju Kumari Rani, Nisha Singh, Pushplata Sankhwar, Sabuhi Qureshi

Published in: The Journal of Obstetrics and Gynecology of India | Issue 4/2013

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Abstract

Objective

A prospective cohort study in a teaching hospital to assess the efficacy and safety of neoadjuvant chemotherapy in the treatment of locally advanced carcinoma cervix.

Method

Neoadjuvant chemotherapy in the form of cisplatin 75 mg/m2 and paclitaxel 135 mg/m2 on day 1 and repeated at 14 days’ interval for up to a maximum of three courses.

Results

Neoadjuvant chemotherapy in cervical cancer was effective in the downstaging of the disease. Downstaging was observed in 19.23 % of patients after two cycles and in 50 % of patients after three cycle of NACT. Operability increases to 33.3 and 38.4 % after two and three cycles of NACT, respectively. Complete pathological response was observed in 37.5 % of patients after NACT. No significant adverse effect in the feasibility of surgery was observed.

Conclusion

The present study showed that neoadjuvant chemotherapy was an effective and well-tolerated mode of therapy with significantly less morbidity and mortality.
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Metadata
Title
The Efficacy and Safety of Neoadjuvant Chemotherapy in Treatment of Locally Advanced Carcinoma Cervix
Authors
Uma Singh
Neetu Ahirwar
Anju Kumari Rani
Nisha Singh
Pushplata Sankhwar
Sabuhi Qureshi
Publication date
01-08-2013
Publisher
Springer India
Published in
The Journal of Obstetrics and Gynecology of India / Issue 4/2013
Print ISSN: 0971-9202
Electronic ISSN: 0975-6434
DOI
https://doi.org/10.1007/s13224-012-0342-6

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