Skip to main content
Top
Published in: Indian Journal of Surgical Oncology 3/2022

16-05-2022 | Lymphoma | Review Article

Gastrosplenic Fistula: a Systematic Review

Authors: Saurabh Borgharia, Preeti Juneja, Priya Hazrah, Romesh Lal, Neeti Kapur, Poras Chaudhary

Published in: Indian Journal of Surgical Oncology | Issue 3/2022

Login to get access

Abstract

Gastrosplenic fistula is an unusual complication of benign as well as malignant gastric and splenic pathologies. This pathology acquires an important clinical significance due to its rare association with life-threatening upper gastrointestinal haemorrhage. The aim of this article is to review the English-language literature in order to gain a better understanding of etiological factors, diagnostic evaluation, and management of gastrosplenic fistula. The systematic search of the literature was performed on PubMed and MEDLINE from January 1950 to September 2020 according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement. We retrieved 44 articles matching our selection criteria from the search. There were 3 case series, 37 case reports, and 4 review of the literature. In our appraisal of articles published in PUBMED, a total of 36 cases of malignant and 10 cases of benign gastrosplenic fistula could be identified. Gastrosplenic fistula is an exceptional complication of malignancies of the gastrointestinal tract. Lymphomas particularly arising from the spleen are the commonest cause. Gastric adenocarcinoma causing GSF is extremely rare. Most cases occur spontaneously, but at times, it can be secondary to tumour necrosis following chemotherapy.
Literature
1.
go back to reference Garcia MA, Bernardos GL, Vaquero RA, MenchénViso L, Turégano FF (2009) Spontaneous gastrosplenic fistula secondary to primary gastric lymphoma. Rev Esp Enferm Dig 101:76–78 Garcia MA, Bernardos GL, Vaquero RA, MenchénViso L, Turégano FF (2009) Spontaneous gastrosplenic fistula secondary to primary gastric lymphoma. Rev Esp Enferm Dig 101:76–78
2.
go back to reference Dellaportas D, Vezakis A, Fragulidis G, Tasoulis M, Karamitopoulou E, Polydorou A. Gastrosplenic fistula secondary to lymphoma, manifesting as upper gastrointestinal bleeding. Endoscopy 2011, 43. Dellaportas D, Vezakis A, Fragulidis G, Tasoulis M, Karamitopoulou E, Polydorou A. Gastrosplenic fistula secondary to lymphoma, manifesting as upper gastrointestinal bleeding. Endoscopy 2011, 43.
3.
go back to reference Jain V, Pauli E, Sharzehi K, Moyer M (2011) Spontaneous gastrosplenic fistula secondary to diffuse large B-cell lymphoma. Gastrointest Endosc 73:608–609CrossRef Jain V, Pauli E, Sharzehi K, Moyer M (2011) Spontaneous gastrosplenic fistula secondary to diffuse large B-cell lymphoma. Gastrointest Endosc 73:608–609CrossRef
4.
go back to reference Rothermel LD, Chadwick CL, Thambi-Pillai T (2010) Gastrosplenic fistula: etiologies, diagnostic studies, and surgical management. Int Surg 95:270–272PubMed Rothermel LD, Chadwick CL, Thambi-Pillai T (2010) Gastrosplenic fistula: etiologies, diagnostic studies, and surgical management. Int Surg 95:270–272PubMed
5.
go back to reference deScoville A, Bovy P, Demeester P (1967) Radiologic aerosplenomegaly caused by necrotizing splenic lymphosarcoma with double fistulization into the digestive tract. Acta Gastro-Enterol Belg 30:841–847 deScoville A, Bovy P, Demeester P (1967) Radiologic aerosplenomegaly caused by necrotizing splenic lymphosarcoma with double fistulization into the digestive tract. Acta Gastro-Enterol Belg 30:841–847
6.
go back to reference Krause R, Larsen CR, Scholz FJ (1990) Gastrosplenic fistula: complication of adenocarcinoma of stomach. Comput Med Imaging Graph 14:273–276CrossRef Krause R, Larsen CR, Scholz FJ (1990) Gastrosplenic fistula: complication of adenocarcinoma of stomach. Comput Med Imaging Graph 14:273–276CrossRef
7.
go back to reference Martinez JD, Moya L, Hernandez G, Viola L (2015) Rev Gastroenterol Peru 35:165–167PubMed Martinez JD, Moya L, Hernandez G, Viola L (2015) Rev Gastroenterol Peru 35:165–167PubMed
8.
go back to reference Pizzirusso F, Gillet JP, Fobe D. Isolated spleen metastatic involvement from a colorectal adenocarcinoma complicated with a gastrosplenic fistula. A case report and literature review. Acta Chir Belg. 2004;104:214–6 Pizzirusso F, Gillet JP, Fobe D. Isolated spleen metastatic involvement from a colorectal adenocarcinoma complicated with a gastrosplenic fistula. A case report and literature review. Acta Chir Belg. 2004;104:214–6
9.
go back to reference Kerem M, Sakrak O, Yilmaz TU, Gultekin FA, Dursun A, Bedirli A (2006) Spontaneous gastrosplenic fistula in primary gastric lymphoma: surgical management. Asian J Surg 29:287–290CrossRef Kerem M, Sakrak O, Yilmaz TU, Gultekin FA, Dursun A, Bedirli A (2006) Spontaneous gastrosplenic fistula in primary gastric lymphoma: surgical management. Asian J Surg 29:287–290CrossRef
10.
go back to reference Macmahon CE, Lund P: Gastrocolic fistulae of malignant origin. A consideration of its nature and report of five cases. Am J Surg 1963 Aug,106:333–47 Macmahon CE, Lund P: Gastrocolic fistulae of malignant origin. A consideration of its nature and report of five cases. Am J Surg 1963 Aug,106:333–47
11.
go back to reference Bubenik O, Lopez MJ, Greco AO, Kraybill WG, Cherwitz DL (1983) Gastrosplenic fistula following successful chemotherapy for disseminated histiocytic lymphoma. Cancer 52(994):6 Bubenik O, Lopez MJ, Greco AO, Kraybill WG, Cherwitz DL (1983) Gastrosplenic fistula following successful chemotherapy for disseminated histiocytic lymphoma. Cancer 52(994):6
12.
go back to reference Moran M, Bilgiç I, Dizen H, EvrenDilektaşlı, TankutKöseoğlu, Özmen M. Spontaneous gastrosplenic fistula resulting from primary gastric lymphoma: case report and review of the literature. Balkan Medical Journal 2011;28:205–8 Moran M, Bilgiç I, Dizen H, EvrenDilektaşlı, TankutKöseoğlu, Özmen M. Spontaneous gastrosplenic fistula resulting from primary gastric lymphoma: case report and review of the literature. Balkan Medical Journal 2011;28:205–8
13.
go back to reference David M, Mahvi and Seth B. Krantz. Stomach. In Textbook of surgery, The biological basis of modern surgical practice. 19th edition. Edited by Courtney M. Townsend, R. Daniel Beauchamp, B. Mark Evers, Kenneth L. Mattox.Philadelphia: Saunders Elsevier; 2012:1182–1226 David M, Mahvi and Seth B. Krantz. Stomach. In Textbook of surgery, The biological basis of modern surgical practice. 19th edition. Edited by Courtney M. Townsend, R. Daniel Beauchamp, B. Mark Evers, Kenneth L. Mattox.Philadelphia: Saunders Elsevier; 2012:1182–1226
14.
go back to reference Seib CD, Rocha FG, Hwang DG, Shoji BT (2009) Gastrosplenic fistula from Hodgkin’s lymphoma. J Clin Oncol 10:27 Seib CD, Rocha FG, Hwang DG, Shoji BT (2009) Gastrosplenic fistula from Hodgkin’s lymphoma. J Clin Oncol 10:27
15.
16.
go back to reference Maillo C, Bau J (2009) Gastrosplenic and thoracosplenic fistula due to primary untreated splenic lymphoma. Rev Esp Enferm Dig 101:222–223PubMed Maillo C, Bau J (2009) Gastrosplenic and thoracosplenic fistula due to primary untreated splenic lymphoma. Rev Esp Enferm Dig 101:222–223PubMed
17.
go back to reference Moghazy KM (2008) Gastrosplenic fistula following chemotherapy for lymphoma. Gulf J Oncolog 3:64–67 Moghazy KM (2008) Gastrosplenic fistula following chemotherapy for lymphoma. Gulf J Oncolog 3:64–67
18.
go back to reference Bird MA, Amjadi D, Behrns KE (2002) Primary splenic lymphoma complicated by hematemesis and gastric erosion. South Med J 95:941–942CrossRef Bird MA, Amjadi D, Behrns KE (2002) Primary splenic lymphoma complicated by hematemesis and gastric erosion. South Med J 95:941–942CrossRef
19.
go back to reference Hiltunen KM, Airo I, Mattila J, Helve O (1991) Massively bleeding gastrosplenic fistula following cytostatic chemotherapy of a malignant lymphoma. J Clin Gastroenterol 13:478–481CrossRef Hiltunen KM, Airo I, Mattila J, Helve O (1991) Massively bleeding gastrosplenic fistula following cytostatic chemotherapy of a malignant lymphoma. J Clin Gastroenterol 13:478–481CrossRef
20.
go back to reference Julian A. Abrams, Timothy C. Wang. From adenocarcinoma and other tumours of the stomach.In Gastrointestinal and liver disease: pathophysiology/diagnosis/management. Volume 1. 9th edition.Edited by Mark Feldman, Lawrence S.Friedman, Lawrence J Brandt. Philadelphia: Saunders Elsevier; 2010:887–906 Julian A. Abrams, Timothy C. Wang. From adenocarcinoma and other tumours of the stomach.In Gastrointestinal and liver disease: pathophysiology/diagnosis/management. Volume 1. 9th edition.Edited by Mark Feldman, Lawrence S.Friedman, Lawrence J Brandt. Philadelphia: Saunders Elsevier; 2010:887–906
21.
go back to reference Blanchi A, Bour B, Alami O (1995) Spontaneous gastrosplenic fistula revealing high-grade centroblastic lymphoma: endoscopic findings. Gastrointest Endosc 42:587–589CrossRef Blanchi A, Bour B, Alami O (1995) Spontaneous gastrosplenic fistula revealing high-grade centroblastic lymphoma: endoscopic findings. Gastrointest Endosc 42:587–589CrossRef
22.
go back to reference Khan F, Vessal S, McKimm E, D'Souza R. Spontaneous gastrosplenic fistula secondary to primary splenic lymphoma. BMJ Case Rep. 2010:bcr0420102932 Khan F, Vessal S, McKimm E, D'Souza R. Spontaneous gastrosplenic fistula secondary to primary splenic lymphoma. BMJ Case Rep. 2010:bcr0420102932
23.
go back to reference Carolin KA, Prakash SH, Silva YJ (1997) Gastrosplenic fistulas: a case report and review of the literature. Am Surg 63:1007–1010PubMed Carolin KA, Prakash SH, Silva YJ (1997) Gastrosplenic fistulas: a case report and review of the literature. Am Surg 63:1007–1010PubMed
24.
go back to reference Choi JE, Chung HJ, Lee HG (2002) Spontaneous gastrosplenic fistula: a rare complication of splenic diffuse large cell lymphoma. Abdom Imaging 27:728–730CrossRef Choi JE, Chung HJ, Lee HG (2002) Spontaneous gastrosplenic fistula: a rare complication of splenic diffuse large cell lymphoma. Abdom Imaging 27:728–730CrossRef
25.
go back to reference Puppala R, Harvey Wl. Spontaneous gastrosplenic fistula in primary gastric lymphoma: case report and review of literature. Clin Radiol Extra. 2005; 60:20–2 Puppala R, Harvey Wl. Spontaneous gastrosplenic fistula in primary gastric lymphoma: case report and review of literature. Clin Radiol Extra. 2005; 60:20–2
26.
go back to reference Aribaş BK, Başkan E, Altinyollar H, Ungül U, Cengız A, Erdıl HF (2008) Gastrosplenic fistula due to splenic large cell lymphoma diagnosed by percutaneous drainage before surgical treatment. Turk J Gastroenterol 19:69–70PubMed Aribaş BK, Başkan E, Altinyollar H, Ungül U, Cengız A, Erdıl HF (2008) Gastrosplenic fistula due to splenic large cell lymphoma diagnosed by percutaneous drainage before surgical treatment. Turk J Gastroenterol 19:69–70PubMed
27.
go back to reference Cary ER, Tremaine WJ, Banks PM, Nagorney DM (1989) Isolated Crohn’s disease of the stomach. Mayo Clin Proc 64:776–779 CrossRef Cary ER, Tremaine WJ, Banks PM, Nagorney DM (1989) Isolated Crohn’s disease of the stomach. Mayo Clin Proc 64:776–779 CrossRef
28.
go back to reference Al-Ashgar HI, Khan MQ, Ghamdi AM, Bamehriz FY, Maghfoor I (2007) Gastrosplenic fistula in Hodgkin’s lymphoma treated successfully by laparoscopic surgery and chemotherapy. Saudi Med J 28:1898–1900PubMed Al-Ashgar HI, Khan MQ, Ghamdi AM, Bamehriz FY, Maghfoor I (2007) Gastrosplenic fistula in Hodgkin’s lymphoma treated successfully by laparoscopic surgery and chemotherapy. Saudi Med J 28:1898–1900PubMed
29.
go back to reference Palmowski M, Zechmann C, Satzl S et al (2008) Large gastrosplenic fistula after effective treatment of abdominal diffuse large-B-cell lymphoma. Ann Hematol 87:337–338CrossRef Palmowski M, Zechmann C, Satzl S et al (2008) Large gastrosplenic fistula after effective treatment of abdominal diffuse large-B-cell lymphoma. Ann Hematol 87:337–338CrossRef
32.
go back to reference Saito M, Miyashita K, Miura Y, Harada S, Ogasawara R, Izumiyama K et al (2019) Successful treatment of gastrosplenic fistula arising from diffuse large B-cell lymphoma with chemotherapy: two case reports. Case Rep Oncol 12:376–383CrossRef Saito M, Miyashita K, Miura Y, Harada S, Ogasawara R, Izumiyama K et al (2019) Successful treatment of gastrosplenic fistula arising from diffuse large B-cell lymphoma with chemotherapy: two case reports. Case Rep Oncol 12:376–383CrossRef
33.
go back to reference Kang DH, Huh J, Lee JH, Jeong YK, Cha HJ (2017) Gastrosplenic fistula occurring in lymphoma patients: systematic review with a new case of extranodal NK T-cell lymphoma. World J Gastroenterol 23:6491–6499CrossRef Kang DH, Huh J, Lee JH, Jeong YK, Cha HJ (2017) Gastrosplenic fistula occurring in lymphoma patients: systematic review with a new case of extranodal NK T-cell lymphoma. World J Gastroenterol 23:6491–6499CrossRef
34.
go back to reference Gentilli S, Oldani O, Zanni M, Ferreri E, Terrone A, Valente G, et al. Gastrosplenic fistula as a complication of chemotherapy for large B-cell lymphoma. Ann Ital Chir.2016;26:87:S2239253X16025731 Gentilli S, Oldani O, Zanni M, Ferreri E, Terrone A, Valente G, et al. Gastrosplenic fistula as a complication of chemotherapy for large B-cell lymphoma. Ann Ital Chir.2016;26:87:S2239253X16025731
35.
go back to reference Senapati J, Devasia AJ, Sudhakar S, Viswabandya A (2014) Asymptomatic gastrosplenic fistula in a patient with marginal zonal lymphoma transformed to diffuse large B cell lymphoma- a case report and review of literature. Ann Hematol 93:1599–1602CrossRef Senapati J, Devasia AJ, Sudhakar S, Viswabandya A (2014) Asymptomatic gastrosplenic fistula in a patient with marginal zonal lymphoma transformed to diffuse large B cell lymphoma- a case report and review of literature. Ann Hematol 93:1599–1602CrossRef
36.
go back to reference Delgado Sanchez MJ, Bernardos Rodriguez A, Serrano Diez-Canedo J, Buezas Martinez G, Alamo JC (1994) Gastrosplenic fistula from primary lymphoma of the spleen. Rev Enferm Dig 86:543–545 Delgado Sanchez MJ, Bernardos Rodriguez A, Serrano Diez-Canedo J, Buezas Martinez G, Alamo JC (1994) Gastrosplenic fistula from primary lymphoma of the spleen. Rev Enferm Dig 86:543–545
37.
go back to reference Harris NL, Aisenberg AC, Meyer JE, Ellman L, Elman A: Diffuse large cell (histiocytic) lymphoma of the spleen. Clinical and pathological characteristic of ten cases. Cancer. 1984,142:711–4. Harris NL, Aisenberg AC, Meyer JE, Ellman L, Elman A: Diffuse large cell (histiocytic) lymphoma of the spleen. Clinical and pathological characteristic of ten cases. Cancer. 1984,142:711–4.
38.
go back to reference Leeds IL, Haut ER, Barnett CC (2016) Splenic abscess complicated by gastrosplenic fistula. J Trauma Acute Care Surg 81:612–614CrossRef Leeds IL, Haut ER, Barnett CC (2016) Splenic abscess complicated by gastrosplenic fistula. J Trauma Acute Care Surg 81:612–614CrossRef
39.
go back to reference Lee KJ, Yoo JS, Jeon H, Cho SK, Lee JH, Ha SS et al (2015) A case of splenic tuberculosis forming a Gastrosplenic fistula. Korean J Gastroenterol 66:168–171CrossRef Lee KJ, Yoo JS, Jeon H, Cho SK, Lee JH, Ha SS et al (2015) A case of splenic tuberculosis forming a Gastrosplenic fistula. Korean J Gastroenterol 66:168–171CrossRef
40.
go back to reference Ballas K, Rafailidis S, Demertzidis C, Eugenidis N, Alatsakis M, Zafiriadou E et al (2005) Gastrosplenic fistula: a rare complication of splenic abscess. Surg Pract 9:153–155CrossRef Ballas K, Rafailidis S, Demertzidis C, Eugenidis N, Alatsakis M, Zafiriadou E et al (2005) Gastrosplenic fistula: a rare complication of splenic abscess. Surg Pract 9:153–155CrossRef
41.
go back to reference Nikolaidis N, Giouleme O, Gkisakis D, Grammatikos N (2005) Posttraumatic splenic abscess with gastrosplenic fistula. GastrointestEndosc 61:771–772 Nikolaidis N, Giouleme O, Gkisakis D, Grammatikos N (2005) Posttraumatic splenic abscess with gastrosplenic fistula. GastrointestEndosc 61:771–772
42.
go back to reference Kryshtalskyi N, Shafir MS (1991) Splenic abscess with gastrosplenic fistula. Can Fam Physician 37:465–470 Kryshtalskyi N, Shafir MS (1991) Splenic abscess with gastrosplenic fistula. Can Fam Physician 37:465–470
43.
go back to reference Glick SN, Levine MS, Teplick SK, Gasparaitis A (1987) Splenic penetration by benign gastric ulcer: Preoperative recognition with C T. Radiology 163:637–639CrossRef Glick SN, Levine MS, Teplick SK, Gasparaitis A (1987) Splenic penetration by benign gastric ulcer: Preoperative recognition with C T. Radiology 163:637–639CrossRef
44.
go back to reference Joffe N, Antonioli DA (1981) Penetration into spleen by benign gastric ulcer. Clin Radiol 32:177–181CrossRef Joffe N, Antonioli DA (1981) Penetration into spleen by benign gastric ulcer. Clin Radiol 32:177–181CrossRef
45.
go back to reference Immelman EJ (1975) Rupture of a subcapsular hematoma of the spleen resulting from a penetrating gastric ulcer. South Afr J Surg 13:261–263 Immelman EJ (1975) Rupture of a subcapsular hematoma of the spleen resulting from a penetrating gastric ulcer. South Afr J Surg 13:261–263
46.
go back to reference Stoica T, Dragomir T, Gabrovescu D, Laky D, Marinescu M (1973) Ulcer of the fornix perforated into the spleen, simulating a gastric diverticulum. Chirurgia (Bucur) 22(509):12 Stoica T, Dragomir T, Gabrovescu D, Laky D, Marinescu M (1973) Ulcer of the fornix perforated into the spleen, simulating a gastric diverticulum. Chirurgia (Bucur) 22(509):12
Metadata
Title
Gastrosplenic Fistula: a Systematic Review
Authors
Saurabh Borgharia
Preeti Juneja
Priya Hazrah
Romesh Lal
Neeti Kapur
Poras Chaudhary
Publication date
16-05-2022
Publisher
Springer India
Published in
Indian Journal of Surgical Oncology / Issue 3/2022
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI
https://doi.org/10.1007/s13193-022-01551-5

Other articles of this Issue 3/2022

Indian Journal of Surgical Oncology 3/2022 Go to the issue