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01-02-2019 | Peritonectomy | Review Article

Pelvic Exenteration with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS + HIPEC) for Rectal Cancer—Case Series with Review of Literature

Authors: Rajesh S. Shinde, Rajgopal Acharya, Naveena AN Kumar, Sohan Solanki, Ashwin Desouza, Avanish Saklani

Published in: Indian Journal of Surgical Oncology | Special Issue 1/2019

Abstract

Incidence of synchronous peritoneal metastases (PM) in colorectal cancer is approximately 5%, with another 5% of the patients develop metachronous PM. Colorectal PM has been hypothesized to be a loco-regional disease rather than a systemic spread, and cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has been considered as a viable treatment option. Pelvic exenteration is an established treatment option for locally advanced rectal cancer, but it is associated with significant morbidity. However, there are no studies evaluating the role of such procedure probably because the majority consider it as an exclusion criterion. Here, we present our experience with three cases of locally advanced rectal cancer with PM, treated successfully with pelvic exenteration and CRS-HIPEC.

Lemmens VE, Klaver YL, Verwaal VJ, Rutten HJ, Coebergh JW, de Hingh IH (2011) Predictors and survival of synchronous peritoneal carcinomatosis of colorectal origin: a population-based study. Int J Cancer 128(11):2717–2725CrossRefPubMed

Segelman J, Granath F, Holm T, Machado M, Mahteme H, Martling A (2012) Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer. Br J Surg 99(5):699–705CrossRefPubMed

Coccolini F, Gheza F, Lotti M, Virzi S, Iusco D, Ghermandi C et al (2013) Peritoneal carcinomatosis. World J Gastroenterol 19(41):6979–6994CrossRefPubMedPubMedCentral

Franko J, Ibrahim Z, Gusani NJ, Holtzman MP, Bartlett DL, Zeh HJ III (2010) Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion versus systemic chemotherapy alone for colorectal peritoneal carcinomatosis. Cancer 116(16):3756–3762CrossRefPubMed

Meyerhardt JA, Mayer RJ (2005) Systemic therapy for colorectal cancer. N Engl J Med 352(5):476–487CrossRefPubMed

Nadler A, McCart JA, Govindarajan A (2015) Peritoneal Carcinomatosis from colon cancer: a systematic review of the data for cytoreduction and intraperitoneal chemotherapy. Clin Colon Rectal Surg 28(4):234–246CrossRefPubMedPubMedCentral

Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H et al (2003) Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J Clin Oncol 21(20):3737–3743CrossRef

Cashin PH, Mahteme H, Spång N, Syk I, Frodin JE, Torkzad M et al (2016) Cytoreductive surgery and intraperitoneal chemotherapy versus systemic chemotherapy for colorectal peritoneal metastases: a randomised trial. Eur J Cancer 53:155–162CrossRefPubMed

Henderson N, Polignano F (2015) PTH-312. 5 year results of radical resection and hipec for colorectal cancer peritoneal metastases. Gut 64:A546–A547

10.

Quenet F, Elias D, Roca L Goere D, Ghouti L, Pocard M et al (2018) A UNICANCER phase III trial of hyperthermic intra-peritoneal chemotherapy (HIPEC) for colorectal peritoneal carcinomatosis (PC): PRODIGE 7. J Clin Oncol 36(18):1

11.

van Erning FN, van Steenbergen LN, Lemmens VE, Rutten HJ, Martijn H, van Spronsen DJ et al (2014) Conditional survival for long-term colorectal cancer survivors in the Netherlands: who do best? Eur J Cancer 50(10):1731–1739CrossRefPubMed

12.

Van Leersum NJ, Snijders HS, Henneman D, Kolfschoten NE, Gooikar GA, ten Berge MG et al (2013) The Dutch surgical colorectal audit. Eur J Surg Oncol 39(10):1063–1070CrossRefPubMed

13.

Simkens GA, Rovers KP, Nienhuijs SW, de Hingh IH (2017) Patient selection for cytoreductive surgery and HIPEC for the treatment of peritoneal metastases from colorectal cancer. Cancer Manag Res 9:259–266CrossRefPubMedPubMedCentral

14.

Simkens GA, van Oudheusden TR, Braam HJ, Wiezer MJ, Nienhuijs SW, Rutten HJ, van Ramshorst B, de Hingh IH (2016) Cytoreductive surgery and HIPEC offers similar outcomes in patients with rectal peritoneal metastases compared to colon cancer patients: a matched case control study. J Surg Oncol 113(5):548–553CrossRefPubMed

15.

Kwakman R, Schrama AM, van Olmen JP, Otten RH, de Lange-de Klerk ES, de Cuba EM et al (2016) Clinicopathological parameters in patient selection for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal cancer metastases: a meta-analysis. Ann Surg 263(6):1102–1111CrossRefPubMed

16.

Bacalbasa N, Balescu I (2016) Pelvic exenteration as part of cytoreductive surgery for advanced stage or relapsed ovarian cancer. Eur J Surg Oncol 42(9):S158CrossRef

Title: Pelvic Exenteration with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS + HIPEC) for Rectal Cancer—Case Series with Review of Literature
Authors: Rajesh S. Shinde
Rajgopal Acharya
Naveena AN Kumar
Sohan Solanki
Ashwin Desouza
Avanish Saklani
Publication date: 01-02-2019
Publisher: Springer India
Keywords: Peritonectomy
Rectal Cancer
Surgery
Rectal Cancer
Cytostatic Therapy
Colorectal Cancer
Colorectal Cancer
Published in: Indian Journal of Surgical Oncology / Issue Special Issue 1/2019
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI: https://doi.org/10.1007/s13193-019-00882-0

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Pelvic Exenteration with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS + HIPEC) for Rectal Cancer—Case Series with Review of Literature

Abstract

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