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Published in: Indian Journal of Surgical Oncology 4/2013

01-12-2013 | Original Article

Minimally Invasive Esophagectomy in the Elderly

Authors: Shailesh Puntambekar, Rahul Kenawadekar, Archit Pandit, Akshay Nadkarni, Saurabh Joshi, Geetanjali Agarwal, Nasir Ahmad Bhat, Jainul Malik, Sunil Reddy

Published in: Indian Journal of Surgical Oncology | Issue 4/2013

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Abstract

Objective

A retrospective analysis of a prospectively maintained database to evaluate our experience in elderly patients (>70 years) undergoing Thoracolaparoscopic esophagectomy for cancer oesophagus. To ascertain whether age, is a limiting factor for patients undergoing minimally invasive esophagectomy.

Methods

All Patients above 70 years of age, referred to the Gastro-esophageal clinic were included in the study. Tumours were staged as per AJCC 6th ed. 2002. Patients diagnosed with T1/2/3, N0/1 lesion of the mid/lower oesophagus (Infra Azygous) and type I and II Gastro esophageal junction tumours were included in the study. Patients with ASA grade IV were excluded. All patients who underwent Thoracolaparoscopic esophagectomy from January 2009 till January 2012 were evaluated for their perioperative outcomes.

Results

Sixty eight patients underwent Minimal Invasive esophagectomy from January 2009 to January 2012. There were 45 males and 23 females. The average age in elderly group was 75.76 ± 5.96 years (range 70 to 91). Mean operative time was 178.84 ± 65.26 min, mean blood loss 143.84 ml(range 32–450 ml), mean ICU stay 3.84 days(range 2–11 days) and mean hospital stay was 12.76 days(range 8–21 days). Pneumonia and Cardiac related complications occurred in 10.30 % and 1.47 % patients respectively. None of the procedures required conversion to open thoracotomy.

Conclusions

Thoracolaparoscopic esophagectomy is feasible and surgically safe in elderly patients with low morbidity and mortality. Thus age of a patient should not be considered a limiting factor.

Ultramini Abstract

This is an original article about our experience of thoracolaparoscopic esophagectomy for cancer esophagus in elderly patients. After analyzing the data we feel that age of the patient cannot be a truly limiting factor for patient diagnosed of esophageal cancer to undergo minimally invasive esophagectomy.
Literature
2.
go back to reference Scott Bolton J (2001) Esophagectomy for adenocarcinoma in patients 45 years of age and younger. J Gastrointest Surg 5:620–5PubMedCrossRef Scott Bolton J (2001) Esophagectomy for adenocarcinoma in patients 45 years of age and younger. J Gastrointest Surg 5:620–5PubMedCrossRef
3.
go back to reference Stein HJ, Siewert JR (2004) Improved prognosis of resected esophageal cancer. World J Surg 28:520–5PubMedCrossRef Stein HJ, Siewert JR (2004) Improved prognosis of resected esophageal cancer. World J Surg 28:520–5PubMedCrossRef
4.
go back to reference Pennathur A, Luketich JD (2008) Resection for esophageal cancer: strategies for optimal management. Ann Thorac Surg 85:S751–6PubMedCrossRef Pennathur A, Luketich JD (2008) Resection for esophageal cancer: strategies for optimal management. Ann Thorac Surg 85:S751–6PubMedCrossRef
5.
go back to reference Sauvanet A, Mariette C, Thomas P, Lozac’h P, Segol P, Tiret E et al (2005) Mortality and morbidity after resection for adenocarcinoma of the gastroesophageal junction: predictive factors. J Am Coll Surg 201:253–62PubMedCrossRef Sauvanet A, Mariette C, Thomas P, Lozac’h P, Segol P, Tiret E et al (2005) Mortality and morbidity after resection for adenocarcinoma of the gastroesophageal junction: predictive factors. J Am Coll Surg 201:253–62PubMedCrossRef
6.
go back to reference Bollschweiler E (2000) Preoperative risk analysis in patients with adenocarcinoma or squamous cell carcinoma of the oesophagus. Brit J Surg 87:1106–10PubMedCrossRef Bollschweiler E (2000) Preoperative risk analysis in patients with adenocarcinoma or squamous cell carcinoma of the oesophagus. Brit J Surg 87:1106–10PubMedCrossRef
7.
go back to reference Abunasra H, Lewis S, Beggs L, Duffy J, Beggs D, Morgan E (2005) Predictors of operative death after oesophagectomy for carcinoma. Br J Surg 92:1029–33PubMedCrossRef Abunasra H, Lewis S, Beggs L, Duffy J, Beggs D, Morgan E (2005) Predictors of operative death after oesophagectomy for carcinoma. Br J Surg 92:1029–33PubMedCrossRef
8.
go back to reference Ma JY, Wu Z, Wang Y, Zhao YF, Liu LX, Kou YL et al (2006) Clinicopathologic characteristics of esophagectomy for esophageal carcinoma in elderly patients. World J Gastroenterol 12:1296–9PubMed Ma JY, Wu Z, Wang Y, Zhao YF, Liu LX, Kou YL et al (2006) Clinicopathologic characteristics of esophagectomy for esophageal carcinoma in elderly patients. World J Gastroenterol 12:1296–9PubMed
9.
go back to reference Moskovitz AH, Rizk NP, Venkatraman E, Bains MS, Flores RM, Park BJ et al (2006) Mortality increases for octogenarians undergoing esophagogastrectomy for esophageal cancer. Ann Thorac Surg 82:2031–6PubMedCrossRef Moskovitz AH, Rizk NP, Venkatraman E, Bains MS, Flores RM, Park BJ et al (2006) Mortality increases for octogenarians undergoing esophagogastrectomy for esophageal cancer. Ann Thorac Surg 82:2031–6PubMedCrossRef
10.
go back to reference Poon RT, Law SY, Chu KM, Branicki FJ, Wong J (1998) Esophagectomy for carcinoma of the esophagus in the elderly: results of current surgical management. Ann Surg 227:357–64PubMedCrossRef Poon RT, Law SY, Chu KM, Branicki FJ, Wong J (1998) Esophagectomy for carcinoma of the esophagus in the elderly: results of current surgical management. Ann Surg 227:357–64PubMedCrossRef
11.
go back to reference Sabel MS, Smith JL, Nava HR, Mollen K, Douglass HO, Gibbs JF (2002) Esophageal resection for carcinoma in patients older than 70 years. Ann Surg Oncol 9:210–4PubMedCrossRef Sabel MS, Smith JL, Nava HR, Mollen K, Douglass HO, Gibbs JF (2002) Esophageal resection for carcinoma in patients older than 70 years. Ann Surg Oncol 9:210–4PubMedCrossRef
12.
go back to reference Internullo E, Moons J, Nafteux P, Coosemans W, Decker G, De LP et al (2008) Outcome after esophagectomy for cancer of the esophagus and GEJ in patients aged over 75 years. Eur J Cardiothorac Surg 33:1096–104PubMedCrossRef Internullo E, Moons J, Nafteux P, Coosemans W, Decker G, De LP et al (2008) Outcome after esophagectomy for cancer of the esophagus and GEJ in patients aged over 75 years. Eur J Cardiothorac Surg 33:1096–104PubMedCrossRef
13.
go back to reference Peyre CG, Hagen JA, DeMeester SR, Altorki NK, Ancona E, Griffin SM et al (2008) The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection. Ann Surg 248:549–56PubMedCrossRef Peyre CG, Hagen JA, DeMeester SR, Altorki NK, Ancona E, Griffin SM et al (2008) The number of lymph nodes removed predicts survival in esophageal cancer: an international study on the impact of extent of surgical resection. Ann Surg 248:549–56PubMedCrossRef
14.
go back to reference Lerut T, Nafteux P, Moons J, Coosemans W, Decker G, De Leyn P et al (2004) Three-field lymphadenectomy for carcinoma of the esophagus and gastroesophageal junction in 174 R0 resections: Impact on staging, disease-free survival, and outcome: a plea for adaptation of TNM classification in upper-half esophageal carcinoma. Ann Surg 240:962–72PubMedCrossRef Lerut T, Nafteux P, Moons J, Coosemans W, Decker G, De Leyn P et al (2004) Three-field lymphadenectomy for carcinoma of the esophagus and gastroesophageal junction in 174 R0 resections: Impact on staging, disease-free survival, and outcome: a plea for adaptation of TNM classification in upper-half esophageal carcinoma. Ann Surg 240:962–72PubMedCrossRef
15.
go back to reference Davies AR, Forshaw MJ, Khan AA, Noorani AS, Patel VM, Strauss DC et al (2008) Transhiatal esophagectomy in a high volume institution. World J Surg Oncol 6:88PubMedCentralPubMedCrossRef Davies AR, Forshaw MJ, Khan AA, Noorani AS, Patel VM, Strauss DC et al (2008) Transhiatal esophagectomy in a high volume institution. World J Surg Oncol 6:88PubMedCentralPubMedCrossRef
16.
go back to reference Bailey SH, Bull DA et al (2003) Outcomes after esophagectomy: A ten year retrospective cohort. Ann Thorac Surg 75:217–22PubMedCrossRef Bailey SH, Bull DA et al (2003) Outcomes after esophagectomy: A ten year retrospective cohort. Ann Thorac Surg 75:217–22PubMedCrossRef
17.
go back to reference DePaula AL, Hashiba K, Ferreira EA et al (1996) Transhiatal approach for esophagectomy. In: Tooli J, Gossot D, Hunter JG (eds) Endosurgery. Churchill Livingstone, New York, pp 293–9 DePaula AL, Hashiba K, Ferreira EA et al (1996) Transhiatal approach for esophagectomy. In: Tooli J, Gossot D, Hunter JG (eds) Endosurgery. Churchill Livingstone, New York, pp 293–9
18.
go back to reference Goldminc M, Maddern G, LePrise E et al (1993) Oesophagectomy by a transhiatal approach or thoracotomy: A prospective randomized trial. Br J Surg 80:367–370PubMedCrossRef Goldminc M, Maddern G, LePrise E et al (1993) Oesophagectomy by a transhiatal approach or thoracotomy: A prospective randomized trial. Br J Surg 80:367–370PubMedCrossRef
19.
go back to reference Cuschieri A (1994) Thoracoscopic subtotal oesophagectomy. Endosc Surg Allied Technol 2:21–25PubMed Cuschieri A (1994) Thoracoscopic subtotal oesophagectomy. Endosc Surg Allied Technol 2:21–25PubMed
20.
go back to reference American Joint Commission on Cancer (2002) AJCC cancer staging manual, 6th edn. Springer Verlag, New York American Joint Commission on Cancer (2002) AJCC cancer staging manual, 6th edn. Springer Verlag, New York
21.
go back to reference Cijs TM, Verhoef C, Steyerberg EW, Koppert LB, Khe Tran TC, Wijnhoven BPL, Tilanus HW, de Jonge J (2010) Outcome of esophagectoy for cancer in elderly patients. Ann Thorac Surg 90:900–7PubMedCrossRef Cijs TM, Verhoef C, Steyerberg EW, Koppert LB, Khe Tran TC, Wijnhoven BPL, Tilanus HW, de Jonge J (2010) Outcome of esophagectoy for cancer in elderly patients. Ann Thorac Surg 90:900–7PubMedCrossRef
22.
go back to reference Ma JY, Wu Z, Wang Y, Zhao YF, Liu LX, Kou YL, Zhou QH (2006) Clinicopathologic characteristics of esophagectomy for esophageal carcinoma in elderly patients. World J Gastroenterol 12(8):1296–1299PubMed Ma JY, Wu Z, Wang Y, Zhao YF, Liu LX, Kou YL, Zhou QH (2006) Clinicopathologic characteristics of esophagectomy for esophageal carcinoma in elderly patients. World J Gastroenterol 12(8):1296–1299PubMed
23.
go back to reference Ruol A, Portale G, Zaninotto G, Cagol M, Cavallin F, Castoro C et al (2007) Results of esophagectomy for esophageal cancer in elderly patients: age has little influence on outcome and survival. J Thorac Cardiovasc Surg 133:1186–92PubMedCrossRef Ruol A, Portale G, Zaninotto G, Cagol M, Cavallin F, Castoro C et al (2007) Results of esophagectomy for esophageal cancer in elderly patients: age has little influence on outcome and survival. J Thorac Cardiovasc Surg 133:1186–92PubMedCrossRef
24.
go back to reference Internullo E, Moons J, Nafteux P, Coosemans W, Decker G, De LP et al (2008) Outcome after esophagectomy for cancer of the esophagus and GEJ in patients aged over 75 years. Eur J Cardiothoracic Surg 33:1096–104CrossRef Internullo E, Moons J, Nafteux P, Coosemans W, Decker G, De LP et al (2008) Outcome after esophagectomy for cancer of the esophagus and GEJ in patients aged over 75 years. Eur J Cardiothoracic Surg 33:1096–104CrossRef
25.
go back to reference Pultrum BB, Bosch DJ, Nijsten MW, Rodgers MG, Groen H, Slaets JP, Plukker JT (2010) Extended esophagectomy in elderly patients with esophageal cancer: Minor effect of age alone in determining the postoperative course and survival. Ann Surg Oncol 17(6):1572–80, Epub 2010 Feb 24PubMedCentralPubMedCrossRef Pultrum BB, Bosch DJ, Nijsten MW, Rodgers MG, Groen H, Slaets JP, Plukker JT (2010) Extended esophagectomy in elderly patients with esophageal cancer: Minor effect of age alone in determining the postoperative course and survival. Ann Surg Oncol 17(6):1572–80, Epub 2010 Feb 24PubMedCentralPubMedCrossRef
26.
go back to reference Perry Y, Fernando HC, Buenaventura PO, Christie NA, Luketich JD (2002) Minimally invasive esophagectomy in the elderly. JSLS 6(4):299–304PubMedCentralPubMed Perry Y, Fernando HC, Buenaventura PO, Christie NA, Luketich JD (2002) Minimally invasive esophagectomy in the elderly. JSLS 6(4):299–304PubMedCentralPubMed
27.
go back to reference Puntambekar SP, Agarwal GA, Joshi SN, Rayate NV, Sathe RM, Patil AM. Thoracolaparoscopy in the lateral position for esophageal cancer: The experience of a single institution with 112 consecutive patients. Surg Endosc. 2010 Mar 5. Puntambekar SP, Agarwal GA, Joshi SN, Rayate NV, Sathe RM, Patil AM. Thoracolaparoscopy in the lateral position for esophageal cancer: The experience of a single institution with 112 consecutive patients. Surg Endosc. 2010 Mar 5.
28.
go back to reference Cuschieri A, Shimi S, Banting S (1992) Endoscopic oesophagectomy through a right thoracoscopic approach. J R Coll Surg Edinb 37:7–11PubMed Cuschieri A, Shimi S, Banting S (1992) Endoscopic oesophagectomy through a right thoracoscopic approach. J R Coll Surg Edinb 37:7–11PubMed
29.
go back to reference Dexter SP, Martin IG, McMahon MJ (1996) Radical thoracoscopic esophagectomy for cancer. Surg Endosc 10:147–151PubMedCrossRef Dexter SP, Martin IG, McMahon MJ (1996) Radical thoracoscopic esophagectomy for cancer. Surg Endosc 10:147–151PubMedCrossRef
30.
go back to reference Smithers BM, Gotley DC, McEwan D, Martin I, Bessell J, Doyle L (2001) Thoracoscopic mobilization of the esophagus. A 6 year experience. Surg Endosc 15:176–182PubMedCrossRef Smithers BM, Gotley DC, McEwan D, Martin I, Bessell J, Doyle L (2001) Thoracoscopic mobilization of the esophagus. A 6 year experience. Surg Endosc 15:176–182PubMedCrossRef
31.
go back to reference Law S, Fok M, Chu KM, Wong J (1997) Thoracoscopic esophagectomy for esophageal cancer. Surgery 122:8–14PubMedCrossRef Law S, Fok M, Chu KM, Wong J (1997) Thoracoscopic esophagectomy for esophageal cancer. Surgery 122:8–14PubMedCrossRef
32.
go back to reference Nguyen NT, Follette DM, Wolfe BM, Schneider PD, Roberts P, Goodnight JE (2000) Comparison of minimally invasive esophagectomy with transthoracic and transhiatal esophagectomy. Arch Surg 135:920–925PubMedCrossRef Nguyen NT, Follette DM, Wolfe BM, Schneider PD, Roberts P, Goodnight JE (2000) Comparison of minimally invasive esophagectomy with transthoracic and transhiatal esophagectomy. Arch Surg 135:920–925PubMedCrossRef
33.
go back to reference Lazzarino AI, Nagpal K, Bottle A et al (2010) Open versus minimally invasive esophagectomy: Trends of utilization and associated outcomes in England. Ann Surg 252:292–298PubMedCrossRef Lazzarino AI, Nagpal K, Bottle A et al (2010) Open versus minimally invasive esophagectomy: Trends of utilization and associated outcomes in England. Ann Surg 252:292–298PubMedCrossRef
34.
go back to reference Berger AC, Bloomenthal A, Weksler B et al (2011) Oncologic efficacy is not compromised, and may be improved with minimally invasive esophagectomy. J Am Coll Surg 212:560–568PubMedCrossRef Berger AC, Bloomenthal A, Weksler B et al (2011) Oncologic efficacy is not compromised, and may be improved with minimally invasive esophagectomy. J Am Coll Surg 212:560–568PubMedCrossRef
35.
go back to reference Swanson SJ, Batirel HF, Bueno R et al (2001) Transthoracic esophagectomy with radical mediastinal and abdominal lymph node dissection and cervical esophagogastrostomy for esophageal carcinoma. Ann Thorac Surg 72:1918–1924PubMedCrossRef Swanson SJ, Batirel HF, Bueno R et al (2001) Transthoracic esophagectomy with radical mediastinal and abdominal lymph node dissection and cervical esophagogastrostomy for esophageal carcinoma. Ann Thorac Surg 72:1918–1924PubMedCrossRef
36.
go back to reference Pham TH, Perry KA, Dolan JP et al (2010) Comparison of perioperative outcomes after combined thoracoscopic-laparoscopic esophagectomy and open Ivor-Lewis esophagectomy. Am J Surg 199:594–598PubMedCrossRef Pham TH, Perry KA, Dolan JP et al (2010) Comparison of perioperative outcomes after combined thoracoscopic-laparoscopic esophagectomy and open Ivor-Lewis esophagectomy. Am J Surg 199:594–598PubMedCrossRef
37.
go back to reference Gemmill EH, McCulloch P (2007) Systematic review of minimally invasive resection for gastro-oesophageal cancer. Br J Surg 94:1461–1467PubMedCrossRef Gemmill EH, McCulloch P (2007) Systematic review of minimally invasive resection for gastro-oesophageal cancer. Br J Surg 94:1461–1467PubMedCrossRef
38.
go back to reference Decker G, Coosemans W, De Leyn P, Decaluwé H, Nafteux P, Van Raemdonck D, Lerut T (2009) Minimally invasive esophagectomy for cancer. Eur J Cardiothorac Surg 35:13–20, discussion 20–21PubMedCrossRef Decker G, Coosemans W, De Leyn P, Decaluwé H, Nafteux P, Van Raemdonck D, Lerut T (2009) Minimally invasive esophagectomy for cancer. Eur J Cardiothorac Surg 35:13–20, discussion 20–21PubMedCrossRef
39.
go back to reference Luketich JD, Pennathur A, Awais O et al (2012) Outcomes after minimally invasive esophagectomy, review of over 1000 patients. Ann Surg 256:95–103PubMedCrossRef Luketich JD, Pennathur A, Awais O et al (2012) Outcomes after minimally invasive esophagectomy, review of over 1000 patients. Ann Surg 256:95–103PubMedCrossRef
40.
go back to reference Mamidanna R, Bottle A, Aylin P et al (2012) Short-Term Outcomes Following Open Versus Minimally Invasive Esophagectomy for Cancer in England, A Population-Based National Study. Ann Surg 255:197–203PubMedCrossRef Mamidanna R, Bottle A, Aylin P et al (2012) Short-Term Outcomes Following Open Versus Minimally Invasive Esophagectomy for Cancer in England, A Population-Based National Study. Ann Surg 255:197–203PubMedCrossRef
41.
go back to reference Yaping X, Jinshi L, Xianghui D, Xiaojiang S, Yuanda Z, Jianxiang C, Bo L, Wei L, Hao J, Weimin M (2013) Prognostic impact of postoperative radiation in patients undergoing radical esophagectomy for pathologic lymph node positive esophageal cancer. Radiat Oncol 8:116CrossRef Yaping X, Jinshi L, Xianghui D, Xiaojiang S, Yuanda Z, Jianxiang C, Bo L, Wei L, Hao J, Weimin M (2013) Prognostic impact of postoperative radiation in patients undergoing radical esophagectomy for pathologic lymph node positive esophageal cancer. Radiat Oncol 8:116CrossRef
Metadata
Title
Minimally Invasive Esophagectomy in the Elderly
Authors
Shailesh Puntambekar
Rahul Kenawadekar
Archit Pandit
Akshay Nadkarni
Saurabh Joshi
Geetanjali Agarwal
Nasir Ahmad Bhat
Jainul Malik
Sunil Reddy
Publication date
01-12-2013
Publisher
Springer India
Published in
Indian Journal of Surgical Oncology / Issue 4/2013
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI
https://doi.org/10.1007/s13193-013-0263-6

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