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Published in: Translational Behavioral Medicine 4/2016

01-12-2016 | Original Research

Healthcare system-wide implementation of opioid-safety guideline recommendations: the case of urine drug screening and opioid-patient suicide- and overdose-related events in the Veterans Health Administration

Authors: Penny L. Brennan, Ph.D., Aaron C. Del Re, Ph.D., Patricia T. Henderson, M.S., Jodie A. Trafton, Ph.D.

Published in: Translational Behavioral Medicine | Issue 4/2016

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Abstract

This study provides an example of how healthcare system-wide progress in implementation of opioid-therapy guideline recommendations can be longitudinally assessed and then related to subsequent opioid-prescribed patient health and safety outcomes. Using longitudinal linear mixed effects analyses, we determined that in the Department of Veterans Affairs (VA) healthcare system (n = 141 facilities), over the 4-year interval from 2010 to 2013, a key opioid therapy guideline recommendation, urine drug screening (UDS), increased from 29 to 42 %, with an average within-facility increase rate of 4.5 % per year. Higher levels of UDS implementation from 2010 to 2013 were associated with lower risk of suicide and drug overdose events among VA opioid-prescribed patients in 2013, even after adjusting for patients’ 2012 demographic characteristics and medical and mental health comorbidities. Findings suggest that VA clinicians and healthcare policymakers have been responsive to the 2010 VA/Department of Defense (DOD) UDS treatment guideline recommendation, resulting in improved patient safety for VA opioid-prescribed patients.
Literature
1.
go back to reference Centers for Disease Control and Prevention. CDC grand rounds: prescription drug overdoses—A U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012; 61: 10-13. Centers for Disease Control and Prevention. CDC grand rounds: prescription drug overdoses—A U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012; 61: 10-13.
2.
go back to reference Daubresse M, Chang H-Y, Yu Y, et al. Ambulatory diagnosis and treatment of nonmalignant pain in the United States, 2000–2010. Med Care. 2013; 51: 870-878.CrossRefPubMed Daubresse M, Chang H-Y, Yu Y, et al. Ambulatory diagnosis and treatment of nonmalignant pain in the United States, 2000–2010. Med Care. 2013; 51: 870-878.CrossRefPubMed
3.
go back to reference Substance Abuse and Mental Health Service Administration, Office of Applied Studies. Drug Abuse Warning Network, 2007: National Estimates of Drug-Related Emergency Department Visits. Rockville, MD; 2010. Substance Abuse and Mental Health Service Administration, Office of Applied Studies. Drug Abuse Warning Network, 2007: National Estimates of Drug-Related Emergency Department Visits. Rockville, MD; 2010.
4.
go back to reference Nuckols TK, Anderson L, Popescu I, et al. Opioid prescribing: a systematic review and critical appraisal of guidelines for chronic pain. Ann Intern Med. 2014; 160: 38-47.PubMed Nuckols TK, Anderson L, Popescu I, et al. Opioid prescribing: a systematic review and critical appraisal of guidelines for chronic pain. Ann Intern Med. 2014; 160: 38-47.PubMed
6.
go back to reference Rudd RA, Paulozzi LJ, Bauer MJ, et al. Increases in heroin overdose deaths—28 states 2010 to 2012. MMWR Morb Mortal Wkly Rep. 2014; 63: 834-849. Rudd RA, Paulozzi LJ, Bauer MJ, et al. Increases in heroin overdose deaths—28 states 2010 to 2012. MMWR Morb Mortal Wkly Rep. 2014; 63: 834-849.
7.
go back to reference Midboe AM, Lewis ET, Paik MC, et al. Measurement of adherence to clinical practice guidelines for opioid therapy for chronic pain. Transl Behav Med. 2012; 2: 57-64.CrossRefPubMed Midboe AM, Lewis ET, Paik MC, et al. Measurement of adherence to clinical practice guidelines for opioid therapy for chronic pain. Transl Behav Med. 2012; 2: 57-64.CrossRefPubMed
9.
11.
go back to reference Volkow ND, McLellan AT. Opioid abuse in chronic pain—misconceptions and mitigation strategies. N Engl J Med. 2016; 374: 1253-1263.CrossRefPubMed Volkow ND, McLellan AT. Opioid abuse in chronic pain—misconceptions and mitigation strategies. N Engl J Med. 2016; 374: 1253-1263.CrossRefPubMed
12.
go back to reference Franklin GM. Opioids for chronic noncancer pain: a position paper of the American Academy of Neurology. Neurology. 2014; 83: 1277-1284.CrossRefPubMed Franklin GM. Opioids for chronic noncancer pain: a position paper of the American Academy of Neurology. Neurology. 2014; 83: 1277-1284.CrossRefPubMed
13.
go back to reference Starrels JL, Becker WC, Alford DP, et al. Systematic review: treatment agreements and urine drug testing to reduce opioid misuse in patients with chronic pain. Ann Intern Med. 2010; 152: 712-720.CrossRefPubMed Starrels JL, Becker WC, Alford DP, et al. Systematic review: treatment agreements and urine drug testing to reduce opioid misuse in patients with chronic pain. Ann Intern Med. 2010; 152: 712-720.CrossRefPubMed
14.
go back to reference Canada RE, DiRocco D, Day S. A better approach to opioid-prescribing in primary care. J Fam Pract. 2014; 63: E1-E8.PubMed Canada RE, DiRocco D, Day S. A better approach to opioid-prescribing in primary care. J Fam Pract. 2014; 63: E1-E8.PubMed
15.
go back to reference Fagan MJ, Chen JT, Diaz JA, et al. Do internal medicine residents find pain medication agreements useful? Clin J Pain. 2008; 24: 35-38.CrossRefPubMed Fagan MJ, Chen JT, Diaz JA, et al. Do internal medicine residents find pain medication agreements useful? Clin J Pain. 2008; 24: 35-38.CrossRefPubMed
16.
go back to reference Touchet BK, Yates WR, Coon KA. Opioid contract use associated with physician training level and practice specialty. J Opioid Manag. 2005; 1: 195-200.PubMed Touchet BK, Yates WR, Coon KA. Opioid contract use associated with physician training level and practice specialty. J Opioid Manag. 2005; 1: 195-200.PubMed
17.
go back to reference Im JJ, Shachter RD, Oliva EM, et al. Association of care practices with suicide attempts in US Veterans prescribed opioid medications for chronic pain management. J Gen Intern Med. 2015; 30: 979-991.CrossRefPubMedPubMedCentral Im JJ, Shachter RD, Oliva EM, et al. Association of care practices with suicide attempts in US Veterans prescribed opioid medications for chronic pain management. J Gen Intern Med. 2015; 30: 979-991.CrossRefPubMedPubMedCentral
18.
go back to reference Centers for Disease Control and Prevention. International Classification of Diseases, Ninth Revision, Sixth Edition. 2011. Centers for Disease Control and Prevention. International Classification of Diseases, Ninth Revision, Sixth Edition. 2011.
19.
go back to reference Elixhauser A, Steiner C, Harris D, et al. Comorbidity measures for use with administrative data. Med Care. 1998; 36: 8-27.CrossRefPubMed Elixhauser A, Steiner C, Harris D, et al. Comorbidity measures for use with administrative data. Med Care. 1998; 36: 8-27.CrossRefPubMed
20.
go back to reference Nock MK, Hwang I, Sampson NA, et al. Mental disorders, comorbidity and suicidal behavior: results from the National Comorbidity Survey Replication. Mol Psychol. 2010; 15: 868-76.CrossRef Nock MK, Hwang I, Sampson NA, et al. Mental disorders, comorbidity and suicidal behavior: results from the National Comorbidity Survey Replication. Mol Psychol. 2010; 15: 868-76.CrossRef
21.
go back to reference Seal KH, Shi Y, Cohen G, et al. Association of mental health disorders with prescription opioids and high-risk opioid use in US veterans of Iraq and Afghanistan. JAMA. 2012; 7: 940-7. Seal KH, Shi Y, Cohen G, et al. Association of mental health disorders with prescription opioids and high-risk opioid use in US veterans of Iraq and Afghanistan. JAMA. 2012; 7: 940-7.
23.
go back to reference R Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. Available at: http://www.R-project.org/. Accessibility verified November 2, 2015. R Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. Available at: http://​www.​R-project.​org/​. Accessibility verified November 2, 2015.
24.
go back to reference Bryk SW, Raudenbush AS. Hierarchical Linear Models: Applications and Data Analysis Methods. Thousand Oaks, CA: Sage Publications; 2002. Bryk SW, Raudenbush AS. Hierarchical Linear Models: Applications and Data Analysis Methods. Thousand Oaks, CA: Sage Publications; 2002.
25.
go back to reference Singer JD, Willett JB. Applied Longitudinal Data Analysis: Modeling Change and Event Occurrence. Oxford, UK: Oxford University Press; 2003.CrossRef Singer JD, Willett JB. Applied Longitudinal Data Analysis: Modeling Change and Event Occurrence. Oxford, UK: Oxford University Press; 2003.CrossRef
26.
go back to reference Buscaglia AC, Paik MC, Lewis E, et al. Baseline variation in use of VA/DOD clinical practice guideline recommended opioid prescribing practices across VA health care systems. Clin J Pain. 2015; 31: 803-812. Buscaglia AC, Paik MC, Lewis E, et al. Baseline variation in use of VA/DOD clinical practice guideline recommended opioid prescribing practices across VA health care systems. Clin J Pain. 2015; 31: 803-812.
27.
go back to reference Reisfield GM, Salazar E, Bertholf RL. Rational use and interpretation of urine drug testing in chronic opioid therapy. Ann Clin Lab Sci. 2007; 37: 301-314.PubMed Reisfield GM, Salazar E, Bertholf RL. Rational use and interpretation of urine drug testing in chronic opioid therapy. Ann Clin Lab Sci. 2007; 37: 301-314.PubMed
28.
go back to reference Single topic issue: quality and utility of secondary data for VA research. J Rehabil Res Dev. 2010; 47. Single topic issue: quality and utility of secondary data for VA research. J Rehabil Res Dev. 2010; 47.
29.
go back to reference U.S. Department of Health and Human Services, Office of Disease Prevention and Health Promotion. National Action Plan for Adverse Drug Event Prevention. Washington, DC: USDHHS; 2014. U.S. Department of Health and Human Services, Office of Disease Prevention and Health Promotion. National Action Plan for Adverse Drug Event Prevention. Washington, DC: USDHHS; 2014.
Metadata
Title
Healthcare system-wide implementation of opioid-safety guideline recommendations: the case of urine drug screening and opioid-patient suicide- and overdose-related events in the Veterans Health Administration
Authors
Penny L. Brennan, Ph.D.
Aaron C. Del Re, Ph.D.
Patricia T. Henderson, M.S.
Jodie A. Trafton, Ph.D.
Publication date
01-12-2016
Publisher
Springer US
Published in
Translational Behavioral Medicine / Issue 4/2016
Print ISSN: 1869-6716
Electronic ISSN: 1613-9860
DOI
https://doi.org/10.1007/s13142-016-0423-7

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