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01-09-2016 | Case Report

Cowden Syndrome Detected by FDG PET/CT in an Endometrial Cancer Patient

Authors: Yun Hee Kang, Hye Kyung Lee, Geon Park

Published in: Nuclear Medicine and Molecular Imaging | Issue 3/2016

Abstract

Cowden syndrome (CS) is a rare autosomal dominant disorder characterized by multiple hamartomas in various tissues and cancers (breast, thyroid, and endometrium). We report CS of the esophagus and gastrointestinal tract that was incidentally detected by positron emission tomography/computed tomography (PET/CT) at postoperative surveillance in an endometrial cancer patient. PET/CT showed mildly increased FDG uptake along the entire esophagus and stomach. Upper GI endoscopy and histologic examination revealed glycogenic acanthosis of the esophagus and several hundred gastric polyps. In our case, increased FDG uptake of the esophageal wall contributed to the diagnosis of CS.

Lee EJ, Jung WS, Ko JM, Park HJ. Multiorgan involvements of Cowden disease in a 50-year-old woman: a case report and literature overview. J Korean So Radiol. 2013;69:251–5.CrossRef

Ha M, Chung JW, Hahm KB, Kim YJ, Lee W, An J, et al. A case of Cowden syndrome diagnosed from multiple gastric polyposis. World J Gastroenterol: WJG. 2012;18:861–4.CrossRefPubMedPubMedCentral

Lloyd KM, Dennis M. Cowden’s disease: a possible new symptom complex with multiple system involvement. Ann Intern Med. 1963;58:136–42.CrossRefPubMed

Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E. Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria. J Natl Cancer Inst. 2013;105:1607–16.CrossRefPubMed

Saito K, Nomura E, Sasaki Y, Abe Y, Kanno N, Mizumoto N, et al. Characteristics of small bowel polyps detected in cowden syndrome by capsule endoscopy. Case Rep Gastroint Med. 2015. doi:10.1155/2015/475705.

Campos FG, Habr-Gama A, Kiss DR, Atuí FC, Rawet V, Goldstein PJ, et al. Cowden syndrome: report of two cases and review of clinical presentation and management of a rare colorectal polyposis. Curr Surg. 2006;63:15–9.CrossRefPubMed

Eng C. Will the real Cowden syndrome please stand up: revised diagnostic criteria. J Med Genet. 2000;37:828–30.CrossRefPubMedPubMedCentral

McGarrity TJ, Baker MJW, Ruggiero FM, Thiboutot DM, Hampel H, Zhou X-P, et al. GI polyposis and glycogenic acanthosis of the esophagus associated with PTEN mutation positive Cowden syndrome in the absence of cutaneous manifestations. Am J Gastroenterol. 2003;98:1429–34.CrossRefPubMed

Makis W, Ciarallo A, Hickeson M. The use of 18F-FDG PET/CT in Cowden syndrome to differentiate multifocal gastric carcinoma from extensive benign gastric polyposis. Clin Nucl Med. 2012;37:311–4.CrossRefPubMed

10.

Kamel EM, Thumshirn M, Truninger K, Schiesser M, Fried M, Padberg B, et al. Significance of incidental 18F-FDG accumulations in the gastrointestinal tract in PET/CT: correlation with endoscopic and histopathologic results. J Nucl Med. 2004;45:1804–10.PubMed

11.

Dong A, Wang Y, Zuo C. FDG PET/CT in eosinophilic esophagitis. Clin Nuclear Med. 2014;39:540–3.CrossRef

12.

Roedl JB, Colen RR, King K, Fischman AJ, Mueller PR, Blake MA. Visual PET/CT scoring for nonspecific 18F-FDG uptake in the differentiation of early malignant and benign esophageal lesions. Am J Roentgenol. 2008;191:515–21.CrossRef

Title: Cowden Syndrome Detected by FDG PET/CT in an Endometrial Cancer Patient
Authors: Yun Hee Kang
Hye Kyung Lee
Geon Park
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Nuclear Medicine and Molecular Imaging / Issue 3/2016
Print ISSN: 1869-3474
Electronic ISSN: 1869-3482
DOI: https://doi.org/10.1007/s13139-016-0427-8

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Springer Medicine

Cowden Syndrome Detected by FDG PET/CT in an Endometrial Cancer Patient

Abstract

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Abstract

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