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Published in: Nuclear Medicine and Molecular Imaging 4/2017

01-12-2017 | Interesting Image

Radiation-Induced Giant Cell Granuloma Mimicking Relapsed Hodgkin Lymphoma at FDG-PET/CT

Authors: Hugo J. A. Adams, John M. H. de Klerk, Josien C. Regelink, Ben G. F. Heggelman, Stefan V. Dubois, Thomas C. Kwee

Published in: Nuclear Medicine and Molecular Imaging | Issue 4/2017

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Abstract

A 22-year-old woman was diagnosed with intermediate risk stage II Hodgkin lymphoma and treated with three cycles of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by involved-field radiation therapy. A complete metabolic remission was achieved after two cycles of ABVD, which was maintained until three years after completion of treatment. Follow-up FDG-PET/CT four years after completion of treatment, however, showed a new FDG-avid (Deauville score of 4) lesion in the right scapula, suggesting relapsed disease. Computer tomography (CT)-guided biopsy of this lesion was performed and subsequent histological examination revealed a radiation-induced giant cell granuloma.
Literature
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go back to reference Forte V, Shimotakahara S, Crysdale WS, Thorner P. Recurring giant-cell granuloma at the site of previous radiation therapy. J Otolaryngol. 1990;19:285–7.PubMed Forte V, Shimotakahara S, Crysdale WS, Thorner P. Recurring giant-cell granuloma at the site of previous radiation therapy. J Otolaryngol. 1990;19:285–7.PubMed
Metadata
Title
Radiation-Induced Giant Cell Granuloma Mimicking Relapsed Hodgkin Lymphoma at FDG-PET/CT
Authors
Hugo J. A. Adams
John M. H. de Klerk
Josien C. Regelink
Ben G. F. Heggelman
Stefan V. Dubois
Thomas C. Kwee
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Nuclear Medicine and Molecular Imaging / Issue 4/2017
Print ISSN: 1869-3474
Electronic ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-016-0426-9

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