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01-09-2016 | Interesting Image

False-Positive Radioactive Iodine Uptake Mimicking Miliary Lung Metastases in a Patient Affected by Papillary Thyroid Cancer and IgA Deficiency

Authors: Andrew Paul Demidowich, Amartya Kundu, James C. Reynolds, Francesco S. Celi

Published in: Nuclear Medicine and Molecular Imaging | Issue 3/2016

Abstract

A 42-year-old female with immunoglobulin A deficiency and recurrent sinopulmonary infections underwent thyroidectomy for papillary thyroid cancer (PTC). Follow-up ¹²³I scintigraphy demonstrated diffuse pulmonary uptake, suggesting metastatic disease. However, subsequent pathologic, biochemical and radiographic testing proved that she was in fact disease free, and the initial ¹²³I pulmonary uptake was identified as a false positive. Inflammatory conditions may rarely cause iodine uptake in non-thyroidal tissues due to local retention, organification, and/or immunologic utilization. To avoid exposing patients to unnecessary treatments, it is critical for clinicians to recognize that comorbid pulmonary conditions may mimic metastatic PTC on radioiodine scintigraphy.

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Title: False-Positive Radioactive Iodine Uptake Mimicking Miliary Lung Metastases in a Patient Affected by Papillary Thyroid Cancer and IgA Deficiency
Authors: Andrew Paul Demidowich
Amartya Kundu
James C. Reynolds
Francesco S. Celi
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Nuclear Medicine and Molecular Imaging / Issue 3/2016
Print ISSN: 1869-3474
Electronic ISSN: 1869-3482
DOI: https://doi.org/10.1007/s13139-015-0375-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

False-Positive Radioactive Iodine Uptake Mimicking Miliary Lung Metastases in a Patient Affected by Papillary Thyroid Cancer and IgA Deficiency

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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