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01-08-2018 | Original Article

Heroin Use Is Associated with Ruptured Saccular Aneurysms

Authors: Anil Can, Victor M. Castro, Yildirim H. Ozdemir, Sarajune Dagen, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A. Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T. Weiss, Rose Du

Published in: Translational Stroke Research | Issue 4/2018

Abstract

While cocaine use is thought to be associated with aneurysmal rupture, it is not known whether heroin use increases the risk of rupture in patients with non-mycotic saccular aneurysms. Our goal was to investigate the association between heroin and cocaine use and the rupture of saccular non-mycotic aneurysms. The medical records of 4701 patients with 6411 intracranial aneurysms, including 1201 prospective patients, diagnosed at the Brigham and Women’s Hospital and Massachusetts General Hospital between 1990 and 2016 were reviewed and analyzed. Patients were separated into ruptured and non-ruptured groups. Univariable and multivariable logistic regression analyses were performed to determine the association between heroin, cocaine, and methadone use and the presence of ruptured intracranial aneurysms. In multivariable analysis, current heroin use was significantly associated with rupture status (OR 3.23, 95% CI 1.33–7.83) whereas former heroin use (with and without methadone replacement therapy), and current and former cocaine use were not significantly associated with intracranial aneurysm rupture. In the present study, heroin rather than cocaine use is significantly associated with intracranial aneurysm rupture in patients with non-mycotic saccular cerebral aneurysms, emphasizing the possible role of heroin in the pathophysiology of aneurysm rupture and the importance of heroin cessation in patients harboring unruptured intracranial aneurysms.

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Title: Heroin Use Is Associated with Ruptured Saccular Aneurysms
Authors: Anil Can
Victor M. Castro
Yildirim H. Ozdemir
Sarajune Dagen
Dmitriy Dligach
Sean Finan
Sheng Yu
Vivian Gainer
Nancy A. Shadick
Guergana Savova
Shawn Murphy
Tianxi Cai
Scott T. Weiss
Rose Du
Publication date: 01-08-2018
Publisher: Springer US
Published in: Translational Stroke Research / Issue 4/2018
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-017-0582-y

ACC 2024 Congress

Springer Medicine

Heroin Use Is Associated with Ruptured Saccular Aneurysms

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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