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01-02-2017 | SI: Present and future of neuroplasticity in CNS recovery

Neurogenesis in Stroke Recovery

Authors: Seong-Ho Koh, Hyun-Hee Park

Published in: Translational Stroke Research | Issue 1/2017

Abstract

Stroke, resulting from limited blood flow to the brain, is one of the most important causes of morbidity and mortality worldwide. Stroke is classified as ischemic, due to lack of blood flow, or hemorrhagic, due to bleeding. Because 87 % of strokes are classified as ischemic, this type will be the predominant focus of this review. Except for thrombolytic therapy, there is no established treatment to reduce the neurological deficits caused by ischemic stroke. Therefore, it is necessary to develop new therapeutic strategies designed to improve neurological functions after ischemic stroke. Recently, therapies to enhance neurogenesis after ischemic stroke have been investigated. However, these approaches have not led to successful clinical outcomes. This review addresses the pathophysiology of stroke, neurogenesis after stroke, and how to stimulate these processes based on the current literature. Finally, ongoing clinical trials to improve neurological functions after stroke by enhancing neurogenesis are discussed in this review.

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Title: Neurogenesis in Stroke Recovery
Authors: Seong-Ho Koh
Hyun-Hee Park
Publication date: 01-02-2017
Publisher: Springer US
Published in: Translational Stroke Research / Issue 1/2017
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-016-0460-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Neurogenesis in Stroke Recovery

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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