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01-12-2014 | Editorial

Targeting the Peripheral Inflammatory Response to Stroke: Role of the Spleen

Author: Keith R. Pennypacker

Published in: Translational Stroke Research | Issue 6/2014

Excerpt

The migration of immune cells into the stroke-damaged brain has been reported for decades [1, 2] but its relationship to neurodegeneration is still not completely understood. Cells of the innate immune system are among the first immune cells to extravasate along with the adaptive immune cells infiltrating at later time points [3]. The inflammatory response elicited from these immune cells directly exacerbates the neurodegeneration in the ischemic area as well as indirectly by activating microglia [4]. This observation has led to the use of anti-inflammatory therapies in stroke treatment. One problem with this approach is the potentiation of the post-stroke immune suppression, which leads to increased infection rates [5]. The clinical trial evaluating anti-ICAM-1 therapy is an example of this issue in which one of the adverse events was increased incidence of pneumonia in the treatment group [6]. Thus, therapies that are more selective or targeted at the neurodegenerative response by the immune system could be administered to inhibit further damage with minimal contribution to the post-stroke immune suppression. …

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Title: Targeting the Peripheral Inflammatory Response to Stroke: Role of the Spleen
Author: Keith R. Pennypacker
Publication date: 01-12-2014
Publisher: Springer US
Published in: Translational Stroke Research / Issue 6/2014
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-014-0372-8

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Targeting the Peripheral Inflammatory Response to Stroke: Role of the Spleen

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