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01-06-2020 | SARS-CoV-2 | Review Article

Involvement of the Nervous System in SARS-CoV-2 Infection

Authors: Hao Li, Qun Xue, Xingshun Xu

Published in: Neurotoxicity Research | Issue 1/2020

Abstract

As a severe and highly contagious infectious disease, coronavirus disease 2019 (COVID-19) has caused a global pandemic. Several case reports have demonstrated that the respiratory system is the main target in patients with COVID-19, but the disease is not limited to the respiratory system. Case analysis indicated that the nervous system can be invaded by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and that 36.4% of COVID-19 patients had neurological symptoms. Importantly, the involvement of the CNS may be associated with poor prognosis and disease worsening. Here, we discussed the symptoms and evidence of nervous system involvement (directly and indirectly) caused by SARS-CoV-2 infection and possible mechanisms. CNS symptoms could be a potential indicator of poor prognosis; therefore, the prevention and treatment of CNS symptoms are also crucial for the recovery of COVID-19 patients.

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Title: Involvement of the Nervous System in SARS-CoV-2 Infection
Authors: Hao Li
Qun Xue
Xingshun Xu
Publication date: 01-06-2020
Publisher: Springer US
Keywords: SARS-CoV-2
COVID-19
Published in: Neurotoxicity Research / Issue 1/2020
Print ISSN: 1029-8428
Electronic ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-020-00219-8

At a glance: The STEP trials

Springer Medicine

Involvement of the Nervous System in SARS-CoV-2 Infection

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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