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Canadian Journal of Anesthesia/Journal canadien d'anesthésie

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01-06-2018 | Editorials

Relative importance of strategies for improving the sample size selection and reporting of small randomized clinical trials in anesthesiology

Authors: Emine Ozgur Bayman, PhD, Franklin Dexter, MD, PhD, FASA

Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie | Issue 6/2018

Excerpt

In the current issue of the Journal, Chow et al.1 report the results of a survey of the quality of sample size calculations for two-arm, parallel group, superiority, randomized clinical trials (RCTs) published in six high-impact-factor anesthesiology journals. Trials reporting continuous or binary outcomes published in 2010 and 2016 were included. The authors recorded the variables used to estimate sample size and the actual outcome measures reported for treatment and control groups in the trials. Among 255 RCTs published in these journals in 2010 and 2016, the sample size calculations were not presented or were reported with insufficient data for replication in 33/143 (23%) and 24/112 (21%) of reports, respectively. …

Chow JT, Turkstra TP, Yim E, Jones PM. Sample size calculations for randomized clinical trials published in anesthesiology journals: a comparison of 2010 versus 2016. Can J Anesth 2018; 65. DOI: https://doi.org/10.1007/s12630-018-1109-z.

Dexter F, Shafer SL. Narrative review of statistical reporting checklists, mandatory statistical editing, and rectifying common problems in the reporting of scientific articles. Anesth Analg 2017; 124: 943-7.CrossRefPubMed

Schulz KF, Altman DG, Moher D; CONSORT Group. CONSORT. statement: updated guidelines for reporting parallel group randomised trials. BMJ 2010; 2010(340): c332.

Friede T, Kieser M. Sample size recalculation in internal pilot study designs: a review. Biom J 2006; 48: 537-55.CrossRefPubMed

Wittes J, Brittain E. The role of internal pilot studies in increasing the efficiency of clinical trials. Stat Med 1990; 9: 65-71; discussion 71-2.

Birkett MA, Day SJ. Internal pilot studies for estimating sample size. Stat Med 1994; 13: 2455-63.CrossRefPubMed

Title: Relative importance of strategies for improving the sample size selection and reporting of small randomized clinical trials in anesthesiology
Authors: Emine Ozgur Bayman, PhD
Franklin Dexter, MD, PhD, FASA
Publication date: 01-06-2018
Publisher: Springer US
Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie / Issue 6/2018
Print ISSN: 0832-610X
Electronic ISSN: 1496-8975
DOI: https://doi.org/10.1007/s12630-018-1110-6

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