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Canadian Journal of Anesthesia/Journal canadien d'anesthésie

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01-05-2018 | Editorials

The curious tale of perioperative precision medicine: a story of hydroxocobalamin and cardiac surgery-associated vasoplegia

Authors: Miklos D. Kertai, MD, PhD, Andrew D. Shaw, MB, FRCA, FFICM, FCCM

Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie | Issue 5/2018

Excerpt

Currently, most prevention strategies and therapies are designed for the average patient, and patients are generally not matched with the prevention or treatment strategies that will work best for them. The problem with this approach is that patients are not clones of each other and do not respond in the same way to any given treatment. Clinical trials generally report average treatment effects and are not sensitive to heterogeneity whereby a treatment may be beneficial in one subgroup but ineffective, or even harmful, in another. …

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Shah PR, Reynolds PS, Pal N, Tang D, McCarthy H, Spiess BD. Hydroxocobalamin for the treatment of cardiac surgery-associated vasoplegia: a case series. Can J Anesth 2017. DOI: https://doi.org/10.1007/s12630-017-1029-3.PubMedCentral

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Podgoreanu MV, Kertai MD. Genomic and precision medicine in anesthesia practice. In: Longnecker DE, Newman MF, Zapol WM, Mackey SC, Sandberg WS, editors. Anesthesiology -. 3rd ed. NY: McGraw-Hill Education; 2018. p. 1422-38.

Title: The curious tale of perioperative precision medicine: a story of hydroxocobalamin and cardiac surgery-associated vasoplegia
Authors: Miklos D. Kertai, MD, PhD
Andrew D. Shaw, MB, FRCA, FFICM, FCCM
Publication date: 01-05-2018
Publisher: Springer US
Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie / Issue 5/2018
Print ISSN: 0832-610X
Electronic ISSN: 1496-8975
DOI: https://doi.org/10.1007/s12630-018-1083-5

At a glance: The STEP trials

Springer Medicine

The curious tale of perioperative precision medicine: a story of hydroxocobalamin and cardiac surgery-associated vasoplegia

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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