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Canadian Journal of Anesthesia/Journal canadien d'anesthésie

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01-10-2016 | Editorials

Newer isn’t always better: comparative effectiveness of sevoflurane and isoflurane in cardiac surgery

Authors: Michael R. Mathis, MD, Sachin Kheterpal, MD, MBA

Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie | Issue 10/2016

Excerpt

In this issue of the Journal, Jones et al. 1 present a comparative effectiveness trial showing no difference in clinically relevant outcomes between sevoflurane and isoflurane when used for anesthetic maintenance during cardiac surgery. Specifically, the authors showed that sevoflurane is non-inferior to isoflurane based on a primary outcome composite measure of prolonged intensive care unit (ICU) length of stay (LOS) and all-cause 30-day mortality. Furthermore, the authors found that sevoflurane is not superior to isoflurane on any other clinically important outcome. …

Jones PM. Bainbridge D, Chu MW, et al. Comparison of isoflurane and sevoflurane in cardiac surgery: a randomized non-inferiority comparative effectiveness trial. Can J Anesth 2016; 63: this issue. DOI: 10.1007/s12630-016-0706-y

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Title: Newer isn’t always better: comparative effectiveness of sevoflurane and isoflurane in cardiac surgery
Authors: Michael R. Mathis, MD
Sachin Kheterpal, MD, MBA
Publication date: 01-10-2016
Publisher: Springer US
Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie / Issue 10/2016
Print ISSN: 0832-610X
Electronic ISSN: 1496-8975
DOI: https://doi.org/10.1007/s12630-016-0705-z

At a glance: The STEP trials

Springer Medicine

Newer isn’t always better: comparative effectiveness of sevoflurane and isoflurane in cardiac surgery

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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