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Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie 4/2015

01-04-2015 | Review Article/Brief Review

Transtracheal ultrasound for verification of endotracheal tube placement: a systematic review and meta-analysis

Authors: Saurabh Kumar Das, MD, Nang Sujali Choupoo, MD, Rudrashish Haldar, MD, Amitabh Lahkar, MD

Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie | Issue 4/2015

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Abstract

Purpose

Early confirmation of endotracheal tube placement is of paramount importance to prevent hypoxia and its catastrophic consequences. Despite certain limitations, capnography is considered the gold standard to evaluate the proper placement of an endotracheal tube. Ultrasound is a novel tool with some definitive advantages over capnography. It enables a real-time view and can be performed quickly; furthermore, it is independent of pulmonary blood flow and does not require lung ventilation. In this review, we aimed to evaluate the diagnostic accuracy of transtracheal ultrasound in detecting endotracheal intubation.

Source

We completed an extensive search of MEDLINE®, EMBASE™, The Cochrane Library, KoreaMed, LILACS, OpenGrey, and the World Health Organization International Clinical Trials Registry from their inception to September 4, 2014. The studies that met the inclusion criteria were pooled and a meta-analysis was conducted.

Principal findings

Eleven studies and 969 intubations were included in the final analysis. Eight studies and 713 intubations were performed in emergency situations and the others were carried out in elective situations. Transtracheal ultrasonography’s pooled sensitivity and specificity with 95% confidence intervals (CIs) were 0.98 (95% CI 0.97 to 0.99) and 0.98 (95% CI 0.95 to 0.99), respectively. In emergency scenarios, transtracheal ultrasonography showed an aggregate sensitivity and specificity of 0.98 (95% CI 0.97 to 0.99) and 0.94 (95% CI 0.86 to 0.98), respectively.

Conclusion

Transtracheal ultrasound is a useful tool to confirm endotracheal intubation with an acceptable degree of sensitivity and specificity. It can be used in emergency situations as a preliminary test before final confirmation by capnography.
Appendix
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Literature
1.
go back to reference Grmec S. Comparison of three different methods to confirm tracheal tube placement in emergency intubation. Intensive Care Med 2002; 28: 701-4.CrossRefPubMed Grmec S. Comparison of three different methods to confirm tracheal tube placement in emergency intubation. Intensive Care Med 2002; 28: 701-4.CrossRefPubMed
2.
go back to reference Salem MR. Verification of endotracheal tube position. Anesthesiol Clin North America 2001; 19: 813-39.CrossRefPubMed Salem MR. Verification of endotracheal tube position. Anesthesiol Clin North America 2001; 19: 813-39.CrossRefPubMed
3.
go back to reference Neumar RW, Otto CW, Link MS, et al. 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 8: Adult advanced cardiovascular life support. Circulation 2010; 122: S729-67.CrossRefPubMed Neumar RW, Otto CW, Link MS, et al. 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 8: Adult advanced cardiovascular life support. Circulation 2010; 122: S729-67.CrossRefPubMed
5.
go back to reference Cook TM, Nolan JP. Use of capnography to confirm correct tracheal intubation during cardiac arrest. Anaesthesia 2011; 66: 1183-4.CrossRefPubMed Cook TM, Nolan JP. Use of capnography to confirm correct tracheal intubation during cardiac arrest. Anaesthesia 2011; 66: 1183-4.CrossRefPubMed
6.
go back to reference Werner SL, Smith CE, Goldstein JR, Jones RA, Cydulka RK. Pilot study to evaluate the accuracy of ultrasounography in confirming endotracheal tube placement. Ann Emerg Med 2007; 49: 75-80.CrossRefPubMed Werner SL, Smith CE, Goldstein JR, Jones RA, Cydulka RK. Pilot study to evaluate the accuracy of ultrasounography in confirming endotracheal tube placement. Ann Emerg Med 2007; 49: 75-80.CrossRefPubMed
7.
go back to reference Muslu B, Sert H, Kaya A, et al. Use of sonography for rapid identification of esophageal and tracheal intubation in adult patients. J Ultrasound Med 2011; 30: 671-6.PubMed Muslu B, Sert H, Kaya A, et al. Use of sonography for rapid identification of esophageal and tracheal intubation in adult patients. J Ultrasound Med 2011; 30: 671-6.PubMed
8.
go back to reference Zechner PM, Breitkreutz R. Ultrasound instead of capnometry for confirming tracheal tube placement in an emergency? Resuscitation 2011; 82: 1259-61.CrossRefPubMed Zechner PM, Breitkreutz R. Ultrasound instead of capnometry for confirming tracheal tube placement in an emergency? Resuscitation 2011; 82: 1259-61.CrossRefPubMed
9.
go back to reference Takeda T, Tanigawa K, Tanaka H, Hayashi Y, Goto E, Tanaka K. The assessment of three methods to verify tracheal tube placement in the emergency setting. Resuscitation 2003; 56: 153-7.CrossRefPubMed Takeda T, Tanigawa K, Tanaka H, Hayashi Y, Goto E, Tanaka K. The assessment of three methods to verify tracheal tube placement in the emergency setting. Resuscitation 2003; 56: 153-7.CrossRefPubMed
10.
go back to reference Levine RI, Wayne MA, Miller CC. End-tidal carbon dioxide and outcome of out-of-hospital cardiac arrest. N Engl J Med 1997; 337: 301-6.CrossRefPubMed Levine RI, Wayne MA, Miller CC. End-tidal carbon dioxide and outcome of out-of-hospital cardiac arrest. N Engl J Med 1997; 337: 301-6.CrossRefPubMed
11.
go back to reference Sustic A. Role of ultrasound in the airway management of critically ill patients. Crit Care Med 2007; 35(5 Suppl): S173-7.PubMed Sustic A. Role of ultrasound in the airway management of critically ill patients. Crit Care Med 2007; 35(5 Suppl): S173-7.PubMed
12.
go back to reference Galicinao J, Bush AJ, Godambe SA. Use of bedside ultrasonography for endotracheal tube placement in pediatric patients: a feasibility study. Pediatrics 2007; 120: 1297-303.CrossRefPubMed Galicinao J, Bush AJ, Godambe SA. Use of bedside ultrasonography for endotracheal tube placement in pediatric patients: a feasibility study. Pediatrics 2007; 120: 1297-303.CrossRefPubMed
13.
go back to reference Chou HC, Chong KM, Sim SS, et al. Real-time tracheal ultrasonography for confirmation of endotracheal tube placement during cardiopulmonary resuscitation. Resuscitation 2013; 84: 1708-12.CrossRefPubMed Chou HC, Chong KM, Sim SS, et al. Real-time tracheal ultrasonography for confirmation of endotracheal tube placement during cardiopulmonary resuscitation. Resuscitation 2013; 84: 1708-12.CrossRefPubMed
14.
go back to reference Chou HC, Tseng WP, Wang CH, et al. Tracheal rapid ultrasound exam (T.R.U.E) for confirming endotracheal tube placement during emergency intubation. Resuscitation 2011; 82: 1279-84.CrossRefPubMed Chou HC, Tseng WP, Wang CH, et al. Tracheal rapid ultrasound exam (T.R.U.E) for confirming endotracheal tube placement during emergency intubation. Resuscitation 2011; 82: 1279-84.CrossRefPubMed
15.
go back to reference Hsieh KS, Lee CL, Lin CC, Huang TC, Weng KP, Lu WH. Secondary confirmation of endotracheal tube position by ultrasound image. Crit Care Med 2004; 32(9 Suppl): S374-7.CrossRefPubMed Hsieh KS, Lee CL, Lin CC, Huang TC, Weng KP, Lu WH. Secondary confirmation of endotracheal tube position by ultrasound image. Crit Care Med 2004; 32(9 Suppl): S374-7.CrossRefPubMed
16.
go back to reference Hosseini JS, Talebian MT, Ghafari MH, Eslami V. Secondary confirmation of endotracheal tube position by diaphragm motion in right subcostal ultrasound view. Int J Crit Illn Inj Sci 2013; 3: 113-7.CrossRefPubMedCentralPubMed Hosseini JS, Talebian MT, Ghafari MH, Eslami V. Secondary confirmation of endotracheal tube position by diaphragm motion in right subcostal ultrasound view. Int J Crit Illn Inj Sci 2013; 3: 113-7.CrossRefPubMedCentralPubMed
17.
go back to reference Lyon M, Walton P, Bhalla V, Shiver SA. Ultrasound detection of sliding lung sign by prehospital critical care providers. Am J Emerg Med 2012; 30: 485-8.CrossRefPubMed Lyon M, Walton P, Bhalla V, Shiver SA. Ultrasound detection of sliding lung sign by prehospital critical care providers. Am J Emerg Med 2012; 30: 485-8.CrossRefPubMed
18.
go back to reference Weaver B, Lyon M, Blaivas M. Confirmation of endotracheal tube placement after intubation using the ultrasound sliding lung sign. Acad Emerg Med 2006; 13: 239-44.CrossRefPubMed Weaver B, Lyon M, Blaivas M. Confirmation of endotracheal tube placement after intubation using the ultrasound sliding lung sign. Acad Emerg Med 2006; 13: 239-44.CrossRefPubMed
19.
go back to reference Sim SS, Lien WC, Chou HC, et al. Ultrasonographic lung sliding sign in confirming proper endotracheal intubation during emergency intubation. Resuscitation 2012; 83: 307-12.CrossRefPubMed Sim SS, Lien WC, Chou HC, et al. Ultrasonographic lung sliding sign in confirming proper endotracheal intubation during emergency intubation. Resuscitation 2012; 83: 307-12.CrossRefPubMed
20.
go back to reference Adhikari S, Farrell I, Stolz U. 46 How accurate is ultrasonography in confirming endotracheal tube placement? A meta-analysis. Ann Emerg Med 2012; 60: S18.CrossRef Adhikari S, Farrell I, Stolz U. 46 How accurate is ultrasonography in confirming endotracheal tube placement? A meta-analysis. Ann Emerg Med 2012; 60: S18.CrossRef
21.
go back to reference Herman D, Rudd B. APoo3 Where is the endotracheal tube? A literature review of rapid ultrasound confirmation. Resuscitation 2011; 82(Suppl 1): S10.CrossRef Herman D, Rudd B. APoo3 Where is the endotracheal tube? A literature review of rapid ultrasound confirmation. Resuscitation 2011; 82(Suppl 1): S10.CrossRef
22.
go back to reference Abbasi S, Farsi D, Zare MA, Hajimohammadi M, Rezai M, Hafezimoghadam P. Direct ultrasound methods: a confirmatory technique for proper endotracheal intubation in the emergency department. Eur J Emerg Med 2014; DOI: 10.1097/MEJ.0000000000000108. Abbasi S, Farsi D, Zare MA, Hajimohammadi M, Rezai M, Hafezimoghadam P. Direct ultrasound methods: a confirmatory technique for proper endotracheal intubation in the emergency department. Eur J Emerg Med 2014; DOI: 10.​1097/​MEJ.​0000000000000108​.
23.
go back to reference Milling TJ, Jones M, Khan T, et al. Transtracheal 2-d ultrasound for identification of esophageal intubation. J Emerg Med 2007; 32: 409-14.CrossRefPubMed Milling TJ, Jones M, Khan T, et al. Transtracheal 2-d ultrasound for identification of esophageal intubation. J Emerg Med 2007; 32: 409-14.CrossRefPubMed
24.
go back to reference Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 2011; 155: 529-36.CrossRefPubMed Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 2011; 155: 529-36.CrossRefPubMed
25.
go back to reference Deeks JJ, Wisniewski S, Davenport C. Chapter 4: Guide to the contents of a Cochrane Diagnostic Test Accuracy Protocol. In: Deeks JJ, Bossuyt PM, Gatsonic C (Eds). Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy Version 1.0.0. The Cochrane collaboration, 2013. Available from URL: http://srdta.cochrane.org/ (accessed November 2014). Deeks JJ, Wisniewski S, Davenport C. Chapter 4: Guide to the contents of a Cochrane Diagnostic Test Accuracy Protocol. In: Deeks JJ, Bossuyt PM, Gatsonic C (Eds). Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy Version 1.0.0. The Cochrane collaboration, 2013. Available from URL: http://​srdta.​cochrane.​org/​ (accessed November 2014).
26.
27.
go back to reference Hoffmann B, Gullett JP, Hill HF, et al. Bedside ultrasound of the neck confirms endotracheal tube in emergency intubations. Ultraschall Med 2014; 35: 451-8.CrossRefPubMed Hoffmann B, Gullett JP, Hill HF, et al. Bedside ultrasound of the neck confirms endotracheal tube in emergency intubations. Ultraschall Med 2014; 35: 451-8.CrossRefPubMed
28.
go back to reference Sun JT, Chou HC, Sim SS, et al. Ultrasonography for proper endotracheal tube placement confirmation in out-of-hospital cardiac arrest patients: two-center experience. J Med Ultrasound 2014; 22: 83-7.CrossRef Sun JT, Chou HC, Sim SS, et al. Ultrasonography for proper endotracheal tube placement confirmation in out-of-hospital cardiac arrest patients: two-center experience. J Med Ultrasound 2014; 22: 83-7.CrossRef
29.
go back to reference Adi O, Chuan TW, Rishya M. A feasibility study on bedside upper airway ultrasonography compared to waveform capnography for verifying endotracheal tube location after intubation. Crit Ultrasound J 2013; 5: 7.CrossRefPubMedCentralPubMed Adi O, Chuan TW, Rishya M. A feasibility study on bedside upper airway ultrasonography compared to waveform capnography for verifying endotracheal tube location after intubation. Crit Ultrasound J 2013; 5: 7.CrossRefPubMedCentralPubMed
30.
go back to reference Saglam C, Unluer EE, Karagoz A. Confirmation of endotracheal tube position during resuscitation by bedside ultrasonography. Am J Emerg Med 2013; 31: 248-50.CrossRefPubMed Saglam C, Unluer EE, Karagoz A. Confirmation of endotracheal tube position during resuscitation by bedside ultrasonography. Am J Emerg Med 2013; 31: 248-50.CrossRefPubMed
31.
go back to reference Noh JK, Cho YS. The comparison of airway ultrasonography and continuous waveform capnography to confirm endotracheal tube placement in cardiac arrest patients: prospective observational study. Crit Ultrasound J 2012; 4(Suppl 1): A6.CrossRefPubMedCentral Noh JK, Cho YS. The comparison of airway ultrasonography and continuous waveform capnography to confirm endotracheal tube placement in cardiac arrest patients: prospective observational study. Crit Ultrasound J 2012; 4(Suppl 1): A6.CrossRefPubMedCentral
32.
go back to reference Li J. Capnography alone is imperfect for endotracheal tube placement confirmation during emergency Intubation. J Emerg Med 2001; 20: 223-9.CrossRefPubMed Li J. Capnography alone is imperfect for endotracheal tube placement confirmation during emergency Intubation. J Emerg Med 2001; 20: 223-9.CrossRefPubMed
33.
go back to reference Goksu E, Sayrac V, Oktay C, Kartal M, Akcimen M. How stylet use can effect confirmation of endotracheal tube position using ultrasound. Am J Emerg Med 2010; 28: 32-6.CrossRefPubMed Goksu E, Sayrac V, Oktay C, Kartal M, Akcimen M. How stylet use can effect confirmation of endotracheal tube position using ultrasound. Am J Emerg Med 2010; 28: 32-6.CrossRefPubMed
34.
go back to reference Ma G, Davis DP, Schmitt J, Vilke GM, Chan TC, Hayden SR. The sensitivity and specificity of transcricothyroid ultrasonography to confirm endotracheal tube placement in a cadaver model. J Emerg Med 2007; 32: 405-7.CrossRefPubMed Ma G, Davis DP, Schmitt J, Vilke GM, Chan TC, Hayden SR. The sensitivity and specificity of transcricothyroid ultrasonography to confirm endotracheal tube placement in a cadaver model. J Emerg Med 2007; 32: 405-7.CrossRefPubMed
35.
go back to reference Uya A, Spear D, Patel K, Okada P, Sheeran P, McCreight A. Can novice sonographers accurately locate an endotracheal tube with a saline—filled cuff in a cadaver model? A pilot study. Acad Emerg Med 2012; 19: 361-4.CrossRef Uya A, Spear D, Patel K, Okada P, Sheeran P, McCreight A. Can novice sonographers accurately locate an endotracheal tube with a saline—filled cuff in a cadaver model? A pilot study. Acad Emerg Med 2012; 19: 361-4.CrossRef
36.
go back to reference Slovis TL, Poland RL. Endotracheal tubes in neoanates: sonographic positioning. Radiology 1986; 160: 262-3.CrossRefPubMed Slovis TL, Poland RL. Endotracheal tubes in neoanates: sonographic positioning. Radiology 1986; 160: 262-3.CrossRefPubMed
37.
go back to reference Park SC, Ryu JH, Yeom SR, Jeong JW, Cho SJ. Confirmation of endotracheal intubation by combined ultrasonographic methods in the emergency department. Emerg Med Australas 2009; 21: 293-7.CrossRefPubMed Park SC, Ryu JH, Yeom SR, Jeong JW, Cho SJ. Confirmation of endotracheal intubation by combined ultrasonographic methods in the emergency department. Emerg Med Australas 2009; 21: 293-7.CrossRefPubMed
38.
go back to reference Kerrey BT, Geis GL, Quinn AM, Hornung RW, Ruddy RM. A prospective comparison of diaphragmatic ultrasound and chest radiography to determine endotracheal tube position in a pediatric emergency department. Pediatrics 2009; 123: e1039-44.CrossRefPubMed Kerrey BT, Geis GL, Quinn AM, Hornung RW, Ruddy RM. A prospective comparison of diaphragmatic ultrasound and chest radiography to determine endotracheal tube position in a pediatric emergency department. Pediatrics 2009; 123: e1039-44.CrossRefPubMed
39.
go back to reference Pfeiffer P, Rudolph SS, Borglum J, Isbye DL. Temporal comparison of ultrasound vs. auscultation and capnography in verification of endotracheal tube placement. Acta Anaesthesiol Scand 2011; 55: 1190-5.CrossRefPubMed Pfeiffer P, Rudolph SS, Borglum J, Isbye DL. Temporal comparison of ultrasound vs. auscultation and capnography in verification of endotracheal tube placement. Acta Anaesthesiol Scand 2011; 55: 1190-5.CrossRefPubMed
40.
go back to reference Pfeiffer P, Bache S, Isbye DL, Rudolph SS, Rovsing L, Borglum J. Verification of endotracheal intubation in obese patients – temporal comparison of ultrasound vs. auscultation and capnography. Acta Anaesthesiol Scand 2012; 56: 571-6.CrossRefPubMed Pfeiffer P, Bache S, Isbye DL, Rudolph SS, Rovsing L, Borglum J. Verification of endotracheal intubation in obese patients – temporal comparison of ultrasound vs. auscultation and capnography. Acta Anaesthesiol Scand 2012; 56: 571-6.CrossRefPubMed
41.
go back to reference Buff DD, Fleisher JM, Roca JA, Jaffri M, Wyrwinski PM. Circadian distribution of in-hospital cardiopulmonary arrests on the general medical ward. Arch Intern Med 1992; 152: 1282-8.CrossRefPubMed Buff DD, Fleisher JM, Roca JA, Jaffri M, Wyrwinski PM. Circadian distribution of in-hospital cardiopulmonary arrests on the general medical ward. Arch Intern Med 1992; 152: 1282-8.CrossRefPubMed
42.
go back to reference Xue FS, Liao X, Wang Q. Confirmation of endotracheal tube placement during emergency intubation. Resuscitation 2012; 83: e67.CrossRefPubMed Xue FS, Liao X, Wang Q. Confirmation of endotracheal tube placement during emergency intubation. Resuscitation 2012; 83: e67.CrossRefPubMed
43.
go back to reference Stuntz R, Kochert E, Kehrl T, Schrading W. The effect of sonologist experience on the ability to determine endotracheal tube location using trastracheal ultrasound. Am J Emerg Med 2014; 32: 267-9.CrossRefPubMed Stuntz R, Kochert E, Kehrl T, Schrading W. The effect of sonologist experience on the ability to determine endotracheal tube location using trastracheal ultrasound. Am J Emerg Med 2014; 32: 267-9.CrossRefPubMed
44.
go back to reference Sharma N, Cardenas-Garcia J, Tibb A. Limited training in bedside ultrasound can accurately predict endotracheal tube placement. Chest 2013; 144: 547A (abstract). Sharma N, Cardenas-Garcia J, Tibb A. Limited training in bedside ultrasound can accurately predict endotracheal tube placement. Chest 2013; 144: 547A (abstract).
45.
go back to reference Talley BE, Ginde AA, Raja AS, Sullivan AF, Espinola JA, Camargo CA Jr. Variable access to immediate bedside ultrasound in the emergency department. West J Emerg Med 2011; 12: 96-9.PubMedCentralPubMed Talley BE, Ginde AA, Raja AS, Sullivan AF, Espinola JA, Camargo CA Jr. Variable access to immediate bedside ultrasound in the emergency department. West J Emerg Med 2011; 12: 96-9.PubMedCentralPubMed
46.
go back to reference Smith KJ, Dobranowski J, Yip G, Dauphin A, Choi PT. Cricoid pressure displaces the esophagus: an observational study using magnetic resonance imaging. Anesthesiology 2003; 99: 60-4.CrossRefPubMed Smith KJ, Dobranowski J, Yip G, Dauphin A, Choi PT. Cricoid pressure displaces the esophagus: an observational study using magnetic resonance imaging. Anesthesiology 2003; 99: 60-4.CrossRefPubMed
Metadata
Title
Transtracheal ultrasound for verification of endotracheal tube placement: a systematic review and meta-analysis
Authors
Saurabh Kumar Das, MD
Nang Sujali Choupoo, MD
Rudrashish Haldar, MD
Amitabh Lahkar, MD
Publication date
01-04-2015
Publisher
Springer US
Published in
Canadian Journal of Anesthesia/Journal canadien d'anesthésie / Issue 4/2015
Print ISSN: 0832-610X
Electronic ISSN: 1496-8975
DOI
https://doi.org/10.1007/s12630-014-0301-z

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