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Canadian Journal of Anesthesia/Journal canadien d'anesthésie

Published in:

01-03-2012 | Reports of Original Investigations

The viscous behaviour of HES 130/0.4 (Voluven^®) and HES 260/0.45 (Pentaspan^®)

Authors: Andrew M. Walker, MGIS, Kogan Lee, BSc, Gary M. Dobson, MD, Clifton R. Johnston, PhD

Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie | Issue 3/2012

Abstract

Purpose

Several fluids are available for volume therapy to address hypovolemia. We focus on two hydroxyethyl starches (HES) available for volume expansion in Canada, HES 130/0.4 (Voluven^®) and HES 260/0.45 (Pentaspan^®). Although information is available regarding their pharmacokinetic and risk/benefit profiles, this paper examines their viscous properties.

Methods

Dynamic viscosities of HES 130/0.4 and HES 260/0.45 were measured through capillary viscometry at 21°C and 37°C. The viscosities of the solutions were then measured through a closed flow loop at room temperature across physiologically relevant flow rates that maintained a laminar flow regime.

Results

Measured dynamic viscosity through capillary viscometry for HES 130/0.4 and HES 260/0.45 was 2.76 centipoises (cP) and 7.62 cP, respectively, at 21°C decreasing to 1.74 cP and 4.25 cP, respectively, at 37°C. Pipe flow analysis found that HES 130/0.4 (expiry 02/13) and HES 260/0.45 (expiry 10/10) displayed marginal variation in viscosity suggesting Newtonian behaviour. However, a sample of HES 130/0.4 (expiry 10/10) displayed an appreciable increase in viscosity (13%) at higher flow rates suggesting shear thickening behaviour.

Conclusion

This study represents an innovative characterization of not only the viscosity of two commonly utilized HES solutions but also their viscous behaviour across physiologically relevant flow rates. The shear thickening behaviour of a sample of HES 130/0.40 (expiry 10/10) at high flow rates was not expected, and the effect this result may have on endothelial cell function is unknown.

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Title: The viscous behaviour of HES 130/0.4 (Voluven®) and HES 260/0.45 (Pentaspan®)
Authors: Andrew M. Walker, MGIS
Kogan Lee, BSc
Gary M. Dobson, MD
Clifton R. Johnston, PhD
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Canadian Journal of Anesthesia/Journal canadien d'anesthésie / Issue 3/2012
Print ISSN: 0832-610X
Electronic ISSN: 1496-8975
DOI: https://doi.org/10.1007/s12630-011-9648-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The viscous behaviour of HES 130/0.4 (Voluven^®) and HES 260/0.45 (Pentaspan^®)

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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