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01-12-2016 | Original Investigation

Myocardial blood volume reserve by intravenous contrast echocardiography predicts improvement in left ventricular function in patients with nonischemic dilated cardiomyopathy

Authors: Yoko Miyata-Fukuoka, Hiroya Kawai, Osamu Iseki, Yoshio Yamanaka, Yoshiaki Ueda, Mitsuhiro Yokoyama, Ken-ichi Hirata

Published in: Journal of Echocardiography | Issue 4/2016

Abstract

Background

Impaired myocardial perfusion has been shown in nonischemic dilated cardiomyopathy (DCM). Intravenous myocardial contrast echocardiography (MCE) has been introduced to examine myocardial blood volume (MBV) noninvasively. This study was designed to evaluate if MBV reserve assessed by intravenous MCE with adenosine triphosphate (ATP) can predict efficacy of optimal medical therapy in patients with DCM.

Methods and results

Fifteen DCM patients and 8 control subjects underwent conventional echocardiography and intravenous MCE. We obtained the change in peak contrast integrated backscatter intensity (∆PI) by ATP on the left ventricular (LV) anteroseptal myocardium. After 3 months of optimal medical therapy in DCM patients, we reperformed conventional echocardiography. A good responder to therapy was defined as a decrease in LVDd >5 mm to final LVDd <55 mm and increase in LVEF >20 % to final LVEF >45 %. In DCM patients, ∆PI was lower compared to controls (p < 0.001). Good responders to therapy (n = 6) had higher ∆PI than poor responders (n = 9) (p < 0.05).

Conclusions

The present study demonstrates that the response to the medical therapy in DCM is predicted by the assessment of dilator reserve in MBV. Intravenous MCE with ATP may provide useful information to evaluate MBV reserve.

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Title: Myocardial blood volume reserve by intravenous contrast echocardiography predicts improvement in left ventricular function in patients with nonischemic dilated cardiomyopathy
Authors: Yoko Miyata-Fukuoka
Hiroya Kawai
Osamu Iseki
Yoshio Yamanaka
Yoshiaki Ueda
Mitsuhiro Yokoyama
Ken-ichi Hirata
Publication date: 01-12-2016
Publisher: Springer Japan
Published in: Journal of Echocardiography / Issue 4/2016
Print ISSN: 1349-0222
Electronic ISSN: 1880-344X
DOI: https://doi.org/10.1007/s12574-016-0302-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Myocardial blood volume reserve by intravenous contrast echocardiography predicts improvement in left ventricular function in patients with nonischemic dilated cardiomyopathy

Abstract

Background

Methods and results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods and results

Conclusions

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