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01-09-2014 | Original Article

Does the peritumoral fat signal on MRI exclude malignancy of soft tissue tumor?

Authors: Yasutaka Murahashi, Mitsunori Kaya, Emi Mizushima, Makoto Emori, Tamotsu Soma, Mikito Sasaki, Satoshi Nagoya, Takuro Wada, Toshihiko Yamashita

Published in: European Orthopaedics and Traumatology | Issue 3/2014

Abstract

Objective

MRI is the most sensitive imaging modality in the staging, surgical planning, and following up of malignant soft tissue tumors. However, the ability of MRI to separate benign from malignant lesions is still of limited value for this purpose. We often observe that benign soft tissue tumors are accompanied by a peritumoral fat signal on MRI. The purpose of this study was to determine the value of the peritumoral fat signal in separating benign from malignant soft tissue tumors.

Materials and methods

We retrospectively reviewed 121 patients with soft tissue tumors (52 men, 69 women; median age 54 years). Two musculoskeletal oncologists reviewed the MRI independently and reported on the presence or absence of a peritumoral fat signal. The sensitivity, specificity, and the positive and negative predictive values of the peritumoral fat signal for the prediction of benignancy of soft tissue tumors were calculated.

Results

Peritumoral fat signals were identified in 54 of 64 (84.3 %) benign and 10 of 57 (17.5 %) malignant tumors (p < 0.01). This result had a sensitivity of 84.4 %, specificity of 82.5 %, PPV of 84.4 %, and NPV of 82.5 %.

Conclusion

This study permits the conclusion that the presence of peritumoral fat signals is seemingly an exceptional finding in malignant soft tissue tumors. Observation of this peritumoral fat signal should accordingly influence the management of soft tissue tumors.

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Title: Does the peritumoral fat signal on MRI exclude malignancy of soft tissue tumor?
Authors: Yasutaka Murahashi
Mitsunori Kaya
Emi Mizushima
Makoto Emori
Tamotsu Soma
Mikito Sasaki
Satoshi Nagoya
Takuro Wada
Toshihiko Yamashita
Publication date: 01-09-2014
Publisher: Springer Berlin Heidelberg
Published in: European Orthopaedics and Traumatology / Issue 3/2014
Print ISSN: 1867-4569
Electronic ISSN: 1867-4577
DOI: https://doi.org/10.1007/s12570-013-0241-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Does the peritumoral fat signal on MRI exclude malignancy of soft tissue tumor?

Abstract

Objective

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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