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01-03-2016 | Original Article

Consumption of sucrose from infancy increases the visceral fat accumulation, concentration of triglycerides, insulin and leptin, and generates abnormalities in the adrenal gland

Authors: Yadira Díaz-Aguila, Francisco Castelán, Estela Cuevas, Elena Zambrano, Margarita Martínez-Gómez, Alvaro Muñoz, Jorge Rodríguez-Antolín, Leticia Nicolás-Toledo

Published in: Anatomical Science International | Issue 2/2016

Abstract

Consumption of sugar-sweetened beverages promotes the development of metabolic syndrome (MetS) and type 2 diabetes mellitus in humans. One factor related to the appearance of MetS components is the dysfunction of the adrenal gland. In fact, the experimental generation of hyperglycemia has been associated with morphological and microvascular changes in the adrenal glands of rats. We hypothesized that high sucrose consumption from infancy promotes histological disruption of the adrenal glands associated with the appearance of metabolic syndrome indicators. Male Wistar rats were separated at weaning (21 days old) into two groups: free access to tap water (control group, C) or 30 % sucrose diluted in water (sugar-fed group). After 12 weeks, high sucrose consumption promoted an increase in visceral fat accumulation, adipose cell number, and insulin resistance. Also, a rise in the concentration of triglycerides, very low-density lipoprotein, insulin and leptin was observed. In control rats, a histomorphometric asymmetry between the right and left adrenal glands was found. In the sugar-fed group, sucrose consumption produced a major change in adrenal gland asymmetry. No changes in corticosterone serum level were observed in either group. Our results suggest that a high sucrose liquid-diet from early life alters the morphology of adrenocortical zones, leading to MetS indicators.

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Title: Consumption of sucrose from infancy increases the visceral fat accumulation, concentration of triglycerides, insulin and leptin, and generates abnormalities in the adrenal gland
Authors: Yadira Díaz-Aguila
Francisco Castelán
Estela Cuevas
Elena Zambrano
Margarita Martínez-Gómez
Alvaro Muñoz
Jorge Rodríguez-Antolín
Leticia Nicolás-Toledo
Publication date: 01-03-2016
Publisher: Springer Japan
Published in: Anatomical Science International / Issue 2/2016
Print ISSN: 1447-6959
Electronic ISSN: 1447-073X
DOI: https://doi.org/10.1007/s12565-015-0279-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Consumption of sucrose from infancy increases the visceral fat accumulation, concentration of triglycerides, insulin and leptin, and generates abnormalities in the adrenal gland

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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