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international journal of stomatology & occlusion medicine
Published in: international journal of stomatology & occlusion medicine 1/2015

Open Access 01-03-2015 | original article

Influence of restoration adjustments on prefrontal blood flow

A simplified NIRS preliminary study

Authors: Kenichi Sasaguri, Takero Otsuka, D.D.S, Ph.D, Hiroyuki Tsunashima, Tateshi Shimazaki, Kin-Ya Kubo, Minoru Onozuka

Published in: international journal of stomatology & occlusion medicine | Issue 1/2015

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Abstract

Objective

The aim of this study was to examine, after setting several restorations, the influence of adjusted occlusal interference during gum chewing on blood flow in the prefrontal area as determined using near-infrared spectroscopy.

Material and methods

The physiological rate was assessed using a visual analog scale (VAS) questionnaire. We selected 16 patients who desired prosthetic restorative treatment on the lateral dentition, and eight healthy volunteers. Subjects were divided into three eight-person groups. One group received restorations on the premolar area (PA), another group received restorations on the molar area (MA), and the control group (CT) received no prosthetic restorations. The spectroscope was fastened to the frontal region of the head after placement of the final restoration, but before adjustment.

Results

Pre-adjustment (first gum chewing for CT) blood flow in the prefrontal cortex was measured during gum chewing. Blood flow was again measured during gum chewing after the restoration (second gum chewing for CT) had been adjusted in accordance with the subjective assessment of the patient while wearing the device. The VAS provided quantification of comfort during gum chewing before and after restoration adjustment. For the PA and MA groups, adjusting restorations decreased discomfort significantly during gum chewing. Moreover, in the MA group, prefrontal blood flow was significantly reduced, and blood flow correlated with discomfort.

Conclusions

Activation of the prefrontal area may provide an objective criterion for judging the functionality of occlusion after prosthetic occlusal reconstruction and/or orthodontics.
Literature
1.
Miyachi H, Wake H, Tamaki K, Mitsuhashi A, Ikeda T, Inoue K, Tanaka S, Tanaka K, Miyaoka H. Detecting mental disorders in dental patients with occlusion-related problems. Psychiatry Clin Neurosci. 2007;61:313–19.CrossRefPubMed
2.
Woods CD. Self-reported mental illness in a dental school clinic population. J Dent Educ. 2003;67:500–4.PubMed
3.
Reeves JL 2nd, Merrill RL. Diagnostic and treatment challenges in occlusal dysesthesia. J Calif Dent Assoc. 2007;35:198–207.PubMed
4.
Otsuka T, Saruta J, Greven M, Ono Y, Sasaguri K, Sato S. Effect of orthodontic reconstruction on brain activity in a patient with masticatory dysfunction. J Stomat Occ Med. 2011;4:76–81.CrossRef
5.
Otsuka T, Watanabe K, Hirano Y, Kubo K, Miyake S, Sato S, Sasaguri K. Effects of mandibular deviation on brain activation during clenching: an fMRI preliminary study. Cranio. 2009;27:88–93.PubMed
6.
Greven M, Otsuka T, Zutz L, Weber B, Elger C, Sato S. The amount of TMJ displacement correlates with brain activity. Cranio. 2011;29:291–6.PubMed
7.
Kato K, Ono Y, Kubo KY, Sasaguri K, Watanabe K, Onozuka M, Sato S. Occlusal disharmony suppresses long-term potentiation in the rat hippocampal CA1 region. J Stomat Occ. 2010;3:71–5.CrossRef
8.
Buijs RM, Van Eden CG. The integration of stress by the hypothalamus, amygdala and prefrontal cortex: balance between the autonomic nervous system and the neuroendocrine system. Prog Brain Res. 2000;126:117–32.CrossRefPubMed
9.
Gusnard DA, Akbudak E, Shulman GL, Raichle ME. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci U S A. 2001;98:4259–64.CrossRefPubMedCentralPubMed
10.
Yasui H, Takamoto K, Hori E, Urakawa S, Nagashima Y, Yada Y, Ono T, Nishijo H. Significant correlation between autonomic nervous activity and cerebral hemodynamics during thermotherapy on the neck. Auton Neurosci. 2010;156:96–103.CrossRefPubMed
11.
Momose T, Nishikawa J, Watanabe T, Sasaki Y, Senda M, Kubota K, Sato Y, Funakoshi M, Minakuchi S. Effect of mastication on regional cerebral blood flow in humans examined by positron-emission tomography with 15O-labelled water and magnetic resonance imaging. Arch Oral Biol. 1997;42:57–61.CrossRefPubMed
12.
Onozuka M, Fujita M, Watanabe K, Hirano Y, Niwa M, Nishiyama K, Saito S. Mapping brain region activity during chewing: a functional magnetic resonance imaging study. J Dent Res. 2002;81:743–6.CrossRefPubMed
13.
Onozuka M, Fujita M, Watanabe K, Hirano Y, Niwa M, Nishiyama K, Saito S. Age-related changes in brain regional activity during chewing: a functional magnetic resonance imaging study. J Dent Res. 2003;82:657–60.CrossRefPubMed
14.
Iida T, Fenwick PB, Ioannides AA. Analysis of brain activity immediately before conscious teeth clenching using magnetoencephalographic method. J Oral Rehabil. 2002;34:487–96.CrossRef
15.
Narita N, Kamiya K, Yamamura K, Kawasaki S, Matsumoto T, Tanaka N. Chewing-related prefrontal cortex activation while wearing partial denture prosthesis: pilot study. J Prosthodont Res. 2009;53:126–35.CrossRefPubMed
16.
Takeda T, Shibusawa M, Sudal O, Nakajima K, Ishigami K, Sakatani K. Activity in the premotor area related to bite force control–a functional near-infrared spectroscopy study. Adv Exp Med Biol. 2010;662:479–84.CrossRefPubMed
17.
Shibusawa M, Takeda T, Nakajima K, Jun H, Sekiguchi S, Ishigami K, Sakatani K. Functional near-infrared spectroscopy study on primary motor and somatosensory cortex response to biting and finger clenching. Adv Exp Med Biol. 2010;662:485–90.CrossRefPubMed
18.
Iida T, Kato M, Komiyama O, Suzuki H, Asano T, Kuroki T, Kaneda T, Svensson P, Kawara M. Comparison of cerebral activity during teeth clenching and fist clenching: a functional magnetic resonance imaging study. Eur J Oral Sci. 2010;118:635–41.CrossRefPubMed
19.
Iida T, Sakayanagi M, Svensson P, Komiyama O, Hirayama T, Kaneda T, Sakatani K, Kawara M. Influence of periodontal afferent inputs for human cerebral blood oxygenation during jaw movements. Exp Brain Res. 2012;216:375–84.CrossRefPubMed
20.
Shimazaki T, Otsuka T, Akimoto S, Kubo KY, Sato S, Sasaguri K. Comparison of brain activation via tooth stimulation. J Dent Res. 2012;91:759–63.CrossRefPubMed
21.
Watanabe E, Yamashita Y, Maki A, Ito Y, Koizumi H. Non-invasive functional mapping with multi-channel near infra-red spectroscopic topography in humans. Neurosci Lett. 1996;205:41–4.CrossRefPubMed
22.
Okamoto M, Dan H, Sakamoto K, Takeo K, Shimizu K, Kohno S, Oda I, Isobe S, Suzuki T, Kohyama K, Dan I. Three-dimensional probabilistic anatomical cranio-cerebral correlation via the international 10–20 system oriented for transcranial functional brain mapping. Neuroimage. 2004;21:99–111.CrossRefPubMed
23.
Throckmorton GS, Buschang BH, Hayasaki H, Phelan T. The effects of chewing rates on mandibular kinematics. J Oral Rehabil. 2001;28:328–34.CrossRefPubMed
24.
Hoshi Y, Kobayashi N, Tamura M. Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model. J Appl Physiol. 2001;90:1657–62.PubMed
25.
Yamamoto T, Kato T. Paradoxical correlation between signal in functional magnetic resonance imaging and deoxygenated hemoglobin content in capillaries: a new theoretical explanation. Phys Med Biol. 2002;47:1121–41.CrossRefPubMed
26.
McPherson S, Cummings JL. The frontal lobes and frontal-subcortical circuits in neuropsychiatric disorders. In: Grafman J, Editor. Handbook of neuropsychology. vol. 7, 2. Ed. Amsterdam: Elsevier; 2002. pp. 99–116.
27.
Karl A, Malta LS, Maercker A. Meta-analytic review of event-related potential studies in post-traumatic stress disorder. Biol Psychol. 2006;71:123–47.CrossRefPubMed
28.
Bandler R, Keay KA, Floyd N, Price J. Central circuits mediating patterned autonomic activity during active vs. passive emotional coping. Brain Res Bull. 2000;53:95–104.CrossRefPubMed
29.
Fuchs E, Flügge G. Chronic social stress: effects on limbic brain structures. Physiol Behav. 2003;79:417–27.CrossRefPubMed
Metadata
Title
Influence of restoration adjustments on prefrontal blood flow
A simplified NIRS preliminary study
Authors
Kenichi Sasaguri
Takero Otsuka, D.D.S, Ph.D
Hiroyuki Tsunashima
Tateshi Shimazaki
Kin-Ya Kubo
Minoru Onozuka
Publication date
01-03-2015
Publisher
Springer Vienna
Published in
international journal of stomatology & occlusion medicine / Issue 1/2015
Print ISSN: 1867-2221
Electronic ISSN: 1867-223X
DOI
https://doi.org/10.1007/s12548-015-0122-x

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