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international journal of stomatology & occlusion medicine
Published in: international journal of stomatology & occlusion medicine 4/2012

01-12-2012 | original article

Follow-up of interleukin-1β and neutrophil elastase concentrations in initial wound healing after immediate implant placement in comparison to second stage surgery

A prospective study

Authors: Stefan Lachmann, Jihan Nadir, Robert Haas, Reinhard Gruber, Rudolf Fürhauser, Detlef Axmann, Georg Watzek, Heiner Weber

Published in: international journal of stomatology & occlusion medicine | Issue 4/2012

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Abstract

Purpose

The aim of this study was to compare selected crevicular markers in early wound healing after second stage surgery and immediately restored implant placement.

Material and methods

A total of ten patients (mean age 53 years, 6 females and 4 males) to be treated with all together 20 single tooth implants were enrolled in the study. In 9 cases a second stage surgery after conventional submerged implant healing was performed, in the remaining 11 cases immediate implants were planned prior to tooth extraction. Beginning 1 day after implant installation and provisional restoration according to the copy abutment technique and 1 day after healing abutment insertion, respectively, peri-implant crevicular fluid samples (PICF) were collected, the PICF flow rate was recorded and laboratory assays performed for the assessment of interleukin-1β (IL-1β) and neutrophil elastase (NPE) concentrations (T1). Follow-up intervals were scheduled 1–3 weeks postoperatively (T2–4). Statistical analyses included explorative data analysis and median statistics (Wilcoxon test).

Results

Wound healing was uneventful in all cases and the concentrations of IL-1β and NPE remained stable over the entire observation period. Standard deviations and medians for IL-1β were higher in the second stage implant group with statistically significant differences in the concentrations on T2 and T4. No differences were found for NPE.

Conclusions

The small sample size of this pilot investigation requires careful interpretation of the data presented. Within the limitations of this study it may be concluded that both immediately placed implants and implants at second stage surgery show similar patterns of wound healing with regard to selected markers of peri-implant disease, with minor differences in IL-1β concentrations on follow-up in favor of immediate implantation and restoration.
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Metadata
Title
Follow-up of interleukin-1β and neutrophil elastase concentrations in initial wound healing after immediate implant placement in comparison to second stage surgery
A prospective study
Authors
Stefan Lachmann
Jihan Nadir
Robert Haas
Reinhard Gruber
Rudolf Fürhauser
Detlef Axmann
Georg Watzek
Heiner Weber
Publication date
01-12-2012
Publisher
Springer Vienna
Published in
international journal of stomatology & occlusion medicine / Issue 4/2012
Print ISSN: 1867-2221
Electronic ISSN: 1867-223X
DOI
https://doi.org/10.1007/s12548-012-0060-9

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