Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
World Journal of Pediatrics
Published in: World Journal of Pediatrics 8/2022

Open Access 18-06-2022 | Acute Gastroenteritis | Review Article

Current status of human adenovirus infection in China

Authors: Nai-Ying Mao, Zhen Zhu, Yan Zhang, Wen-Bo Xu

Published in: World Journal of Pediatrics | Issue 8/2022

Login to get access

Abstract

Background

Outbreaks of severe, acute hepatitis among children have recently attracted global attention. The pathogen causing the outbreak remains unknown, but there is growing evidence that it may be associated with human adenovirus (HAdV).

Data sources

A review of adenovirus-related clinical studies, epidemiological studies, etiological studies, and case reports was conducted by reviewers independently.

Results

HAdV can cause a wide variety of clinical symptoms. In the Mainland of China, HAdV infection accounts for 5.8%–13% of patients with acute respiratory infections, and these infections are mainly caused by species B, C, and E of HAdV. For acute conjunctivitis, 39.8%–74.9% of sporadic cases were infected by B and D species of HAdV. Outbreaks of keratoconjunctivitis and pharyngoconjunctival fever related to HAdV infection could be found throughout the country. In pediatric patients with acute gastroenteritis, HAdV-41 was the predominant HAdV type, followed by HAdV species B and C. Several types of HAdV, including HAdV-5, HAdV-7, HAdV-1, and HAdV-2, have previously been reported as potential pathogens associated with HAdV hepatitis in immunocompromised patients. However, few HAdV-related hepatitis cases have been reported in China to date.

Conclusions

There are no systematic surveillance and clinical studies on HAdV hepatitis in China. Therefore, it is imperative to establish a nationwide HAdV virological surveillance system to collect relevant clinical, epidemiological and virological surveillance data and risk factor information as soon as possible to assess the potential risk of HAdV hepatitis among children.
Literature
1.
Chen M, Zhu Z, Huang F, Liu D, Zhang T, Ying D, et al. Adenoviruses associated with acute respiratory diseases reported in Beijing from 2011 to 2013. PLoS One. 2015;10:e0121375.CrossRef
2.
Lei Z, Zhu Z, Wang BM, Mei H, Li H, Ga DZ, et al. Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016. PLoS One. 2017;12:e0185048.CrossRef
3.
Huang YC, Huang SL, Chen SP, Huang YL, Huang CG, Tsao KC, et al. Adenovirus infection associated with central nervous system dysfunction in children. J Clin Virol. 2013;57:300–4.PubMedCrossRef
4.
Portal TM, Reymão TKA, Quinderé Neto GA, Fiuza MKDC, Teixeira DM, Lima ICG, et al. Detection and genotyping of enteric viruses in hospitalized children with acute gastroenteritis in Belém, Brazil: occurrence of adenovirus viremia by species F, types 40/41. J Med Virol. 2019;91:378–84.PubMedCrossRef
5.
Ronan BA, Agrwal N, Carey EJ, De Petris G, Kusne S, et al. Fulminant hepatitis due to human adenovirus. Infection. 2014;42:105–11.PubMedCrossRef
6.
Wold WSMIM, et al. Adenoviruses. In: Knipe DM, et al., editors. Fields virology. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2013. p. 1732–67.
7.
8.
Lukashev AN, Ivanova OE, Eremeeva TP, Iggo RD. Evidence of frequent recombination among human adenoviruses. J Gen Virol. 2008;89:380–8.PubMedCrossRef
9.
10.
11.
Liu C, Xiao Y, Zhang J, Ren L, Li J, Xie Z, et al. Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012. BMC Infect Dis. 2015;15:408.PubMedPubMedCentralCrossRef
12.
Chen Y, Liu F, Wang C, Zhao M, Deng L, Zhong J, et al. Molecular identification and epidemiological features of human adenoviruses associated with acute respiratory infections in hospitalized children in southern China, 2012–2013. PLoS One. 2016;11: e0155412.PubMedPubMedCentralCrossRef
13.
Qu JX, Gu L, Pu ZH, Yu XM, Liu YM, Li R, et al. Beijing Network for adult community-acquired P: viral etiology of community acquired pneumonia among adolescents and adults with mild or moderate severity and its relation to age and severity. BMC Infect Dis. 2015;15:89.PubMedPubMedCentralCrossRef
14.
Xie L, Zhang B, Xiao N, Zhang F, Zhao X, Liu Q, et al. Epidemiology of human adenovirus infection in children hospitalized with lower respiratory tract infections in Hunan. China J Med Virol. 2019;91:392–400.PubMedCrossRef
15.
Xu D, Chen L, Wu X, Ji L. Molecular typing and epidemiology profiles of human adenovirus infection among hospitalized patients with severe acute respiratory infection in Huzhou, China. PLoS One. 2022;17: e0265987.PubMedPubMedCentralCrossRef
16.
Liu T, Li Z, Zhang S, Song S, Julong W, Lin Y, et al. Viral etiology of acute respiratory tract infections in hospitalized children and adults in Shandong Province. China Virol J. 2015;12:168.PubMedCrossRef
17.
Yu J, Xie Z, Zhang T, Lu Y, Fan H, Yang D, et al. Comparison of the prevalence of respiratory viruses in patients with acute respiratory infections at different hospital settings in North China, 2012–2015. BMC Infect Dis. 2018;18:72.PubMedPubMedCentralCrossRef
18.
Huang G, Yu D, Mao N, Zhu Z, Zhang H, Jiang Z, et al. Viral etiology of acute respiratory infection in Gansu Province, China, 2011. PLoS One. 2013;8:e64254.CrossRef
19.
Zeng SZ, Xie LY, Yu T, Zhong LL, Li JS, Duan ZJ, et al. Persistent viral shedding of human adenovirus type 7 in children with severe pneumonia. J Med Virol. 2021;93:4846–55.PubMedCrossRef
20.
21.
Tang L, Wang L, Tan X, Xu W. Adenovirus serotype 7 associated with a severe lower respiratory tract disease outbreak in infants in Shaanxi Province, China. Virol J. 2011;8:23.PubMedPubMedCentralCrossRef
22.
Zhao S, Wan C, Ke C, Seto J, Dehghan S, Zou L, et al. Re-emergent human adenovirus genome type 7d caused an acute respiratory disease outbreak in Southern China after a twenty-one year absence. Sci Rep. 2014;4:7365.PubMedPubMedCentralCrossRef
23.
Qiu S, Li P, Liu H, Wang Y, Liu N, Li C, et al. Whole-genome sequencing for tracing the transmission link between two ARD outbreaks caused by a novel HAdV serotype 7 variant, China. Sci Rep. 2015;5:13617.PubMedPubMedCentralCrossRef
24.
Cai R, Mao N, Dai J, Xiang X, Xu J, Ma Y, et al. Genetic variability of human adenovirus type 7 circulating in mainland China. PLoS One. 2020;15:e0232092.CrossRef
25.
Mao N, Zhu Z, Lei Z, Li Y, Huang F, Yin J, et al. Continued circulation and phylogenetic analysis of human adenovirus-55 in China during 2006–2016. Chin J Exp Clin Vriol. 2018;32:124–9.
26.
Sun B, He H, Wang Z, Qu J, Li X, Ban C, et al. Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study. Crit Care. 2014;18:456.PubMedPubMedCentralCrossRef
27.
Cao B, Huang GH, Pu ZH, Qu JX, Yu XM, Zhu Z, et al. Emergence of community-acquired adenovirus type 55 as a cause of community-onset pneumonia. Chest. 2014;145:79–86.PubMedCrossRef
28.
Wang W, Liu Y, Zhou Y, Gu L, Zhang L, Zhang X, et al. Whole-genome analyses of human adenovirus type 55 emerged in Tibet, Sichuan and Yunnan in China, in 2016. PLoS One. 2017;12:e0189625.CrossRef
29.
30.
Mao N, Zhu Z, Rivailler P, Yang J, Li Q, Han G, et al. Multiple divergent Human mastadenovirus C cocirculating in mainland of China. Infect Genet Evol. 2019;76:104035.PubMedCrossRef
31.
Zhang L, Zhao N, Sha J, Wang C, Jin X, Amer S, et al. Virology and epidemiology analyses of global adenovirus-associated conjunctivitis outbreaks, 1953–2013. Epidemiol Infect. 2016;144:1661–72.PubMedCrossRef
32.
Li J, Lu X, Jiang B, Du Y, Yang Y, Qian H, et al. Adenovirus-associated acute conjunctivitis in Beijing, China, 2011–2013. BMC Infect Dis. 2018;18:135.PubMedPubMedCentralCrossRef
33.
Gong T, Wang HG, Shi Y, Zhou J, Xiao F, Liu SW, et al. The epidemic genotypes of human adenovirus in outpatient children with adenoviral conjunctivitis from 2011 to 2012 in Jiangxi, China. Intervirology. 2019;62:30–6.PubMedCrossRef
34.
Li D, Zhou JN, Li H, He CY, Dai QS, Li XL, et al. An outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 8 in primary school, southwest China. BMC Infect Dis. 2019;19:624.PubMedPubMedCentralCrossRef
35.
Huang G, Yao W, Yu W, Mao L, Sun H, Yao W, et al. Outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 56, China, 2012. PLoS One. 2014;9:e110781.CrossRef
36.
Liu XP, Zhang YM, Bo FB, Li ZZ, Wang DW, Song YS, et al. An outbreak of pharyngoconjunctival fever caused by adenovirus. Dis Surveill. 2007;22:381–3.
37.
Guo JH, Zhang SY, Tian HF, Xu M, Zhou JK. Survey on pharyngoconjunctival fever outbreak caused by type 7 adenovirus. J Enviro Hygiene. 2015;5:76.
38.
Li S, Dong W, Xia Y, Sun J, Zhang C. Epidemiological investigation of an outbreak of pharyngoconjunctival fever caused by adenovirus type 3. Dis Surveill. 2017;32:703–5.
39.
Mu G. An etiological study of acute hemorrhagic conjunctivitis in Beijing area in 1984. Chin J Ophthalmol. 1989;25:20–2.
40.
41.
Primo D, Pacheco GT, Timenetsky MDCST, Luchs A. Surveillance and molecular characterization of human adenovirus in patients with acute gastroenteritis in the era of rotavirus vaccine, Brazil, 2012–2017. J Clin Virol. 2018;109:35–40.PubMedCrossRef
42.
Huang D, Wang Z, Zhang G, Sai L. Molecular and epidemiological characterization of human adenoviruses infection among children with acute diarrhea in Shandong Province, China. Virol J. 2021;18:195.PubMedPubMedCentralCrossRef
43.
Lu L, Jia R, Zhong H, Xu M, Su L, Cao L, et al. Molecular characterization and multiple infections of rotavirus, norovirus, sapovirus, astrovirus and adenovirus in outpatients with sporadic gastroenteritis in Shanghai, China, 2010–2011. Arch Virol. 2015;160:1229–38.PubMedCrossRef
44.
Wu BS, Huang ZM, Weng YW, Chen FQ, Zhang YL, Lin WD, Yu TT. Prevalence and genotypes of rotavirus A and human adenovirus among hospitalized children with acute gastroenteritis in Fujian, China, 2009–2017. Biomed Environ Sci. 2019;32:210–4.PubMed
45.
46.
Schaberg KB, Kambham N, Sibley RK, Higgins JPT. Adenovirus hepatitis: clinicopathologic analysis of 12 consecutive cases from a single institution. Am J Surg Pathol. 2017;41:810–9.PubMedCrossRef
47.
Kojaoghlanian T, Flomenberg P, Horwitz MS. The impact of adenovirus infection on the immunocompromised host. Rev Med Virol. 2003;13:155–71.PubMedCrossRef
48.
Khalifa A, Andreias L, Velpari S. Adenovirus hepatitis in immunocompetent adults. J Investig Med High Impact Case Rep. 2022;10:23247096221079190.PubMedPubMedCentral
49.
Matoq A, Salahuddin A. Acute hepatitis and pancytopenia in healthy infant with adenovirus. Case Rep Pediatr. 2016;2016:8648190.PubMedPubMedCentral
50.
Ozbay Hoşnut F, Canan O, Ozçay F, Bilezikçi B. Adenovirus infection as possible cause of acute liver failure in a healthy child: a case report. Turk J Gastroenterol. 2008;19:281–3.PubMed
51.
Wang WH, Wang HL. Fulminant adenovirus hepatitis following bone marrow transplantation. A case report and brief review of the literature. Arch Pathol Lab Med. 2003;127:e246–8.PubMedCrossRef
52.
Flomenberg P, Babbitt J, Drobyski WR, Ash RC, Carrigan DR, Sedmak GV, et al. Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis. 1994;169:775781.CrossRef
53.
54.
Varki NM, Bhuta S, Drake T, Porter DD. Adenovirus hepatitis in two successive liver transplants in a child. Arch Pathol Lab Med. 1990;114:106–9.PubMed
55.
Boettler T, Csernalabics B, Salié H, Luxenburger H, Wischer L, Alizei ES, et al. SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis. J Hepatol. 2022;S0168–8278:234–43.
Metadata
Title
Current status of human adenovirus infection in China
Authors
Nai-Ying Mao
Zhen Zhu
Yan Zhang
Wen-Bo Xu
Publication date
18-06-2022
Publisher
Springer Nature Singapore
Published in
World Journal of Pediatrics / Issue 8/2022
Print ISSN: 1708-8569
Electronic ISSN: 1867-0687
DOI
https://doi.org/10.1007/s12519-022-00568-8

Other articles of this Issue 8/2022

World Journal of Pediatrics 8/2022 Go to the issue

Review Article

Diagnosis, treatment, and prevention of severe acute hepatitis of unknown etiology in children

Research Letter

Decreased incidence followed by comeback of pediatric infections during the COVID-19 pandemic in Japan

Research Letter

Brazilian adolescents’ lifestyle in the COVID-19 pandemic: a mixed-methods study

Editorial

Acute severe hepatitis of unknown origin in children: considerations from the perspective of immunology

Editorial

Response to the outbreak of severe acute hepatitis of unknown origin in children

Research Letter

Comorbidities, clinical characteristics and outcomes of COVID-19 in pediatric patients in a tertiary medical center in the Netherlands