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World Journal of Pediatrics
Published in: World Journal of Pediatrics 4/2020

01-08-2020 | Obesity | Original Article

High birth weight and its interaction with physical activity influence the risk of obesity in early school-aged children

Authors: Jia-Ru Deng, Wei-Qing Tan, Shu-Yi Yang, Li-Ping Ao, Jian-Ping Liang, Li-Xia Li, Yan-Hui Gao, Yi Yang, Li Liu

Published in: World Journal of Pediatrics | Issue 4/2020

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Abstract

Background

High birth weight (HBW) is associated with childhood obesity, but with inconsistent results. This study investigated the relationship between HBW and childhood obesity, and further explored the interaction of HBW with behavioral and socio-economic determinants of obesity.

Methods

This cross-sectional study enrolled 1906 grade-two children of Guangzhou, China, from June to November, 2016. Overweight/obesity corresponded to a body mass index higher than the sex–age-specific criteria. Abdominal obesity was assessed using the sex-specific waist–height ratio cutoffs. The association of HBW with obesity was evaluated in multivariable logistic regression model. The relative excess risk due to interaction (RERI) and the attributable proportion of interaction (AP) indices were used to measure additive interaction, while applying the interaction of OR index for multiplicative interaction assessment.

Results

Children with HBW had an increased risk of overweight/obesity [odds ratio (OR) = 2.42, 95% confidence interval (CI) = 1.56–3.76] compared with those without HBW. Significant additive interaction of HBW with physical activity was found for overweight/obesity [relative excess risk due to interaction (RERI) = 2.69, 95% CI = 0.62–4.75; attributable proportion of interaction (AP) = 0.72, 95% CI = 0.42–1.02]. The HBW children with insufficient activity had higher odds of overweight/obesity compared to the non-HBW children with sufficient activity (OR = 3.75, 95% CI = 2.06–6.83). In addition, we identified a significant interaction of HBW with household income for abdominal obesity (RERI = 1.20, 95% CI = 0.02–2.37; AP = 0.76, 95% CI = 0.16–1.36).

Conclusions

HBW confers an increased risk for childhood overweight/obesity. Physical activity attenuates the effect of HBW on overweight/obesity, and HBW possibly synergistically interacts with high household income to promote abdominal obesity in childhood.
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Metadata
Title
High birth weight and its interaction with physical activity influence the risk of obesity in early school-aged children
Authors
Jia-Ru Deng
Wei-Qing Tan
Shu-Yi Yang
Li-Ping Ao
Jian-Ping Liang
Li-Xia Li
Yan-Hui Gao
Yi Yang
Li Liu
Publication date
01-08-2020
Publisher
Springer Singapore
Published in
World Journal of Pediatrics / Issue 4/2020
Print ISSN: 1708-8569
Electronic ISSN: 1867-0687
DOI
https://doi.org/10.1007/s12519-020-00336-6

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