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World Journal of Pediatrics
Published in: World Journal of Pediatrics 4/2019

01-08-2019 | Obesity | Meta-analysis

FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis

Authors: Ning-Ning Zhao, Guan-Ping Dong, Wei Wu, Jin-Ling Wang, Rahim Ullah, Jun-Fen Fu

Published in: World Journal of Pediatrics | Issue 4/2019

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Abstract

Background

There is tremendous increase in obesity worldwide. Many factors including diet, life style, genetic, and epigenetic changes contribute to obesity. The fat mass and obesity-associated (FTO) gene polymorphisms are strongly associated with obesity. It has been reported that FTO single-nucleotide polymorphisms (SNPs) are associated with obesity in European populations; however, it was controversial in Chinese population. The present meta-analysis study was designed to investigate the association between FTO polymorphisms and obesity risk in Chinese population.

Methods

The investigators searched studies using the following databases: PubMed, web of science, and Cochrane Central Register of Controlled Trials. A random-effects model was used to calculate the pooled odds ratios (ORs). The heterogeneity among the studies was measured by I2 value. Subgroup analysis was used to find out the potential factors influencing the heterogeneity.

Results

A total of 18 articles including 26 studies were included in the present meta-analysis. Overall, the FTO SNPs were significantly associated with obesity in Chinese population (OR 1.30; 95% CI 1.19–1.42; P < 0.001) under per-allele comparison. The subgroup analysis also showed strong association between four FTO SNPs (rs9939609, rs6499640, rs8050136, and rs1558902) and obesity risk. Furthermore, subgroup analysis stratified by children/adolescent and adult groups showed same trend.

Conclusion

The present meta-analysis indicated that FTO SNPs are associated with obesity risk in both children/adolescents and adults in Chinese population.
Appendix
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Metadata
Title
FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis
Authors
Ning-Ning Zhao
Guan-Ping Dong
Wei Wu
Jin-Ling Wang
Rahim Ullah
Jun-Fen Fu
Publication date
01-08-2019
Publisher
Springer Singapore
Published in
World Journal of Pediatrics / Issue 4/2019
Print ISSN: 1708-8569
Electronic ISSN: 1867-0687
DOI
https://doi.org/10.1007/s12519-019-00254-2

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