Top

ADHD Attention Deficit and Hyperactivity Disorders

Published in:

01-03-2018 | Review Article

Emerging role of miRNA in attention deficit hyperactivity disorder: a systematic review

Authors: Saurabh Srivastav, Susanne Walitza, Edna Grünblatt

Published in: ADHD Attention Deficit and Hyperactivity Disorders | Issue 1/2018

Abstract

Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric disorder whose aetiology still remains elusive. Nevertheless, evidence supports a high genetic contribution that interacts with environmental factors, also known to modulate epigenetic processes. These epigenetic modulators are a class of non-coding RNAs, microRNAs (miRNAs), known as post-transcriptional regulators, which have emerged as prospective players in neuropsychiatric disorders since they play a role in brain development, synapse formation, and the fine-tuning of genes underlying synaptic and memory formation. Here, we review the current literature following a systematic search up until August 2016. The keywords used were “ADHD”, “attention deficit hyperactivity disorder”, “attention hyperactivity” in combination with “miRNA” or “microRNA”. A total of 9 studies out of 34 met inclusion criteria. The results provide preliminary information, shedding light on two important aspects. First, it depicts that miRNAs modulate expression of genes (BDNF, DAT1, HTR2C, HTR1B, SNAP-25) linked to ADHD aetiology. Dysregulation of miRNAs affects regulatory mechanisms of aforementioned genes, which may affect neurodevelopmental processes leading to alterations. Secondly, altered peripheral miRNA levels are observed in both ADHD animal model and humans, suggesting a notion of utilizing circulatory miRNA in disease diagnosis. Therefore, deciphering the role of miRNAs in ADHD seems a promising step in understanding its aetiology.

Available only for authorised users

Abdolmaleky H (2014) Horizons of psychiatric genetics and epigenetics: Where are we and where are we heading? Iran J Psychiatry Behav Sci 8(3):1–10

Abdolmaleky H, Glatt S, Tsuang M (2011) Epigenetics in psychiatry. In: Roach H, Bronner F, Oreffo R (eds) Epigenetic aspects of chronic diseases. Springer, London, pp 163–174CrossRef

Abu-Elneel K, Liu T, Gazzaniga FS, Nishimura Y, Wall DP, Geschwind DH, Lao K, Kosik KS (2008) Heterogeneous dysregulation of microRNAs across the autism spectrum. Neurogenetics 9(3):153–161. doi:10.1007/s10048-008-0133-5 CrossRefPubMed

Alural B, Genc S, Haggarty SJ (2017) Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future. Prog Neuropsychopharmacol Biol Psychiatry 73:87–103. doi:10.1016/j.pnpbp.2016.03.010 CrossRefPubMed

Antshel KM, Zhang-James Y, Wagner KE, Ledesma A, Faraone SV (2016) An update on the comorbidity of ADHD and ASD: a focus on clinical management. Expert Rev Neurother 16(3):279–293. doi:10.1586/14737175.2016.1146591 CrossRefPubMed

Banaschewski T, Becker K, Scherag S, Franke B, Coghill D (2010) Molecular genetics of attention-deficit/hyperactivity disorder: an overview. Eur Child Adolesc Psychiatry 19(3):237–257. doi:10.1007/s00787-010-0090-z CrossRefPubMedPubMedCentral

Banerjee TD, Middleton F, Faraone SV (2007) Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatr 96(9):1269–1274. doi:10.1111/j.1651-2227.2007.00430.x CrossRefPubMed

Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281–297CrossRefPubMed

Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, Sur M, Haggarty SJ (2015) Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder. Mol Psychiatry 20(5):573–584. doi:10.1038/mp.2014.176 CrossRefPubMedPubMedCentral

Belzeaux R, Bergon A, Jeanjean V, Loriod B, Formisano-Treziny C, Verrier L, Loundou A, Baumstarck-Barrau K, Boyer L, Gall V, Gabert J, Nguyen C, Azorin JM, Naudin J, Ibrahim EC (2012) Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode. Transl Psychiatry 2:e185. doi:10.1038/tp.2012.112 CrossRefPubMedPubMedCentral

Beveridge NJ, Gardiner E, Carroll AP, Tooney PA, Cairns MJ (2010) Schizophrenia is associated with an increase in cortical microRNA biogenesis. Mol Psychiatry 15(12):1176–1189. doi:10.1038/mp.2009.84 CrossRefPubMed

Biederman J (2005) Attention-deficit/hyperactivity disorder: a selective overview. Biol Psychiatry 57(11):1215–1220. doi:10.1016/j.biopsych.2004.10.020 CrossRefPubMed

Bonvicini C, Faraone SV, Scassellati C (2016) Attention-deficit hyperactivity disorder in adults: a systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies. Mol Psychiatry 21(7):872–884. doi:10.1038/mp.2016.74 CrossRefPubMedPubMedCentral

Bonvicini C, Faraone SV, Scassellati C (2017) Common and specific genes and peripheral biomarkers in children and adults with attention-deficit/hyperactivity disorder. World J Biol Psychiatry. doi:10.1080/15622975.2017.1282175

Brikell I, Kuja-Halkola R, Larsson H (2015) Heritability of attention-deficit hyperactivity disorder in adults. Am J Med Genet B Neuropsychiatr Genet 168(6):406–413. doi:10.1002/ajmg.b.32335 CrossRefPubMed

Budziszewska B, Basta-Kaim A, Kubera M, Lason W (2010) Immunological and endocrinological pattern in ADHD etiopathogenesis. Przegl Lek 67(11):1200–1204PubMed

Coghill DR, Banaschewski T, Lecendreux M, Soutullo C, Zuddas A, Adeyi B, Sorooshian S (2014) Post hoc analyses of the impact of previous medication on the efficacy of lisdexamfetamine dimesylate in the treatment of attention-deficit/hyperactivity disorder in a randomized, controlled trial. Neuropsychiatr Dis Treat 10:2039–2047. doi:10.2147/NDT.S68273 PubMedPubMedCentral

Corradini I, Verderio C, Sala M, Wilson MC, Matteoli M (2009) SNAP-25 in neuropsychiatric disorders. Ann N Y Acad Sci 1152:93–99. doi:10.1111/j.1749-6632.2008.03995.x CrossRefPubMedPubMedCentral

Cristino AS, Williams SM, Hawi Z, An JY, Bellgrove MA, Schwartz CE, Costa Lda F, Claudianos C (2014) Neurodevelopmental and neuropsychiatric disorders represent an interconnected molecular system. Mol Psychiatry 19(3):294–301. doi:10.1038/mp.2013.16 CrossRefPubMed

Dudley KJ, Li X, Kobor MS, Kippin TE, Bredy TW (2011) Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders. Neurosci Biobehav Rev 35(7):1544–1551. doi:10.1016/j.neubiorev.2010.12.016 CrossRefPubMed

Ebejer JL, Duffy DL, van der Werf J, Wright MJ, Montgomery G, Gillespie NA, Hickie IB, Martin NG, Medland SE (2013) Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits. Twin Res Hum Genet 16(2):560–574. doi:10.1017/thg.2013.12 CrossRefPubMed

Fan HM, Sun XY, Guo W, Zhong AF, Niu W, Zhao L, Dai YH, Guo ZM, Zhang LY, Lu J (2014) Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients. J Psychiatr Res 59:45–52. doi:10.1016/j.jpsychires.2014.08.007 CrossRefPubMed

Faraone SV, Khan SA (2006) Candidate gene studies of attention-deficit/hyperactivity disorder. J Clin Psychiatry 67(Suppl 8):13–20PubMed

Faraone SV, Mick E (2010) Molecular genetics of attention deficit hyperactivity disorder. Psychiatr Clin N Am 33(1):159–180. doi:10.1016/j.psc.2009.12.004 CrossRef

Faraone SV, Biederman J, Mick E (2006) The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med 36(2):159–165. doi:10.1017/S003329170500471X CrossRefPubMed

Fineberg SK, Kosik KS, Davidson BL (2009) MicroRNAs potentiate neural development. Neuron 64(3):303–309. doi:10.1016/j.neuron.2009.10.020 CrossRefPubMed

Forstner AJ, Hofmann A, Maaser A, Sumer S, Khudayberdiev S, Muhleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, Mattheisen M, Schumacher J, Breuer R, Meier S, Herms S, Hoffmann P, Lacour A, Witt SH, Reif A, Muller-Myhsok B, Lucae S, Maier W, Schwarz M, Vedder H, Kammerer-Ciernioch J, Pfennig A, Bauer M, Hautzinger M, Moebus S, Priebe L, Sivalingam S, Verhaert A, Schulz H, Czerski PM, Hauser J, Lissowska J, Szeszenia-Dabrowska N, Brennan P, McKay JD, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Krasnov V, Chuchalin A, Babadjanova G, Pantelejeva G, Abramova LI, Tiganov AS, Polonikov A, Khusnutdinova E, Alda M, Cruceanu C, Rouleau GA, Turecki G, Laprise C, Rivas F, Mayoral F, Kogevinas M, Grigoroiu-Serbanescu M, Propping P, Becker T, Rietschel M, Cichon S, Schratt G, Nothen MM (2015) Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder. Transl Psychiatry 5:e678. doi:10.1038/tp.2015.159 CrossRefPubMedPubMedCentral

Freitag CM, Rohde LA, Lempp T, Romanos M (2010) Phenotypic and measurement influences on heritability estimates in childhood ADHD. Eur Child Adolesc Psychiatry 19(3):311–323. doi:10.1007/s00787-010-0097-5 CrossRefPubMed

Froehlich TE, Anixt JS, Loe IM, Chirdkiatgumchai V, Kuan L, Gilman RC (2011) Update on environmental risk factors for attention-deficit/hyperactivity disorder. Curr Psychiatry Rep 13(5):333–344. doi:10.1007/s11920-011-0221-3 CrossRefPubMedPubMedCentral

Gao Q, Liu L, Qian Q, Wang Y (2014) Advances in molecular genetic studies of attention deficit hyperactivity disorder in China. Shanghai Arch Psychiatry 26(4):194–206. doi:10.3969/j.issn.1002-0829.2014.04.003 PubMedPubMedCentral

Garcia-Martinez I, Sanchez-Mora C, Pagerols M, Richarte V, Corrales M, Fadeuilhe C, Cormand B, Casas M, Ramos-Quiroga JA, Ribases M (2016) Preliminary evidence for association of genetic variants in pri-miR-34b/c and abnormal miR-34c expression with attention deficit and hyperactivity disorder. Transl Psychiatry 6(8):e879. doi:10.1038/tp.2016.151 CrossRefPubMedPubMedCentral

Geaghan M, Cairns MJ (2015) MicroRNA and posttranscriptional dysregulation in psychiatry. Biol Psychiatry 78(4):231–239. doi:10.1016/j.biopsych.2014.12.009 CrossRefPubMed

Gizer IR, Ficks C, Waldman ID (2009) Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 126(1):51–90. doi:10.1007/s00439-009-0694-x CrossRefPubMed

Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R (2004) The Microprocessor complex mediates the genesis of microRNAs. Nature 432(7014):235–240. doi:10.1038/nature03120 CrossRefPubMed

Grünblatt E, Geissler J, Jacob CP, Renner T, Muller M, Bartl J, Gross-Lesch S, Riederer P, Lesch KP, Walitza S, Gerlach M, Schmitt A (2012) Pilot study: potential transcription markers for adult attention-deficit hyperactivity disorder in whole blood. Atten Defic Hyperact Disord 4(2):77–84. doi:10.1007/s12402-012-0074-6 CrossRefPubMed

Gururajan A, Naughton ME, Scott KA, O’Connor RM, Moloney G, Clarke G, Dowling J, Walsh A, Ismail F, Shorten G, Scott L, McLoughlin DM, Cryan JF, Dinan TG (2016) MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c. Transl Psychiatry 6(8):e862. doi:10.1038/tp.2016.131 CrossRefPubMedPubMedCentral

Hawi Z, Cummins TD, Tong J, Johnson B, Lau R, Samarrai W, Bellgrove MA (2015) The molecular genetic architecture of attention deficit hyperactivity disorder. Mol Psychiatry 20(3):289–297. doi:10.1038/mp.2014.183 CrossRefPubMed

Hicks SD, Middleton FA (2016) A comparative review of microRNA expression patterns in autism spectrum disorder. Front Psychiatry 7:176. doi:10.3389/fpsyt.2016.00176 CrossRefPubMedPubMedCentral

Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y, Honma K (2002) Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature 419(6909):841–844. doi:10.1038/nature01123 CrossRefPubMed

Jiang X, Tian F, Du Y, Copeland NG, Jenkins NA, Tessarollo L, Wu X, Pan H, Hu XZ, Xu K, Kenney H, Egan SE, Turley H, Harris AL, Marini AM, Lipsky RH (2008) BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability. J Neurosci 28(5):1118–1130. doi:10.1523/JNEUROSCI.2262-07.2008 CrossRefPubMed

Kandemir H, Erdal ME, Selek S, Ay OI, Karababa IF, Kandemir SB, Ay ME, Yilmaz SG, Bayazit H, Tasdelen B (2014) Evaluation of several micro RNA (miRNA) levels in children and adolescents with attention deficit hyperactivity disorder. Neurosci Lett 580:158–162. doi:10.1016/j.neulet.2014.07.060 CrossRefPubMed

Kandemir H, Erdal ME, Selek S, Izci Ay O, Karababa IF, Ay ME, Kandemir SB, Yilmaz SG, Ekinci S, Tasdelen B, Bayazit H (2015) Microribonucleic acid dysregulations in children and adolescents with obsessive-compulsive disorder. Neuropsychiatr Dis Treat 11:1695–1701. doi:10.2147/NDT.S81884 CrossRefPubMedPubMedCentral

Kanno K, Ishiura S (2011) Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats. J Neurosci Res 89(4):562–575. doi:10.1002/jnr.22593 CrossRefPubMed

Kawamoto T, Noshiro M, Sato F, Maemura K, Takeda N, Nagai R, Iwata T, Fujimoto K, Furukawa M, Miyazaki K, Honma S, Honma K, Kato Y (2004) A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun 313(1):117–124CrossRefPubMed

Kichukova TM, Popov NT, Ivanov HY, Vachev TI (2015) Circulating microRNAs as a novel class of potential diagnostic biomarkers in neuropsychiatric disorders. Folia Med (Plovdiv) 57(3–4):159–172. doi:10.1515/folmed-2015-0035

Kim VN (2005) MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 6(5):376–385. doi:10.1038/nrm1644 CrossRefPubMed

Kim Y, Xia K, Tao R, Giusti-Rodriguez P, Vladimirov V, van den Oord E, Sullivan PF (2014) A meta-analysis of gene expression quantitative trait loci in brain. Transl Psychiatry 4:e459. doi:10.1038/tp.2014.96 CrossRefPubMedPubMedCentral

Kon N, Hirota T, Kawamoto T, Kato Y, Tsubota T, Fukada Y (2008) Activation of TGF-beta/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts. Nat Cell Biol 10(12):1463–1469. doi:10.1038/ncb1806 CrossRefPubMed

Kovacs-Nagy R, Hu J, Ronai Z, Sasvari-Szekely M (2009) SNAP-25: a novel candidate gene in psychiatric genetics. Neuropsychopharmacol Hung 11(2):89–94PubMed

Kozomara A, Griffiths-Jones S (2011) miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 39(Database issue):D152–157. doi:10.1093/nar/gkq1027

Krol J, Loedige I, Filipowicz W (2010) The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 11(9):597–610. doi:10.1038/nrg2843 CrossRefPubMed

Larsson H, Chang Z, D’Onofrio BM, Lichtenstein P (2014) The heritability of clinically diagnosed attention deficit hyperactivity disorder across the lifespan. Psychol Med 44(10):2223–2229. doi:10.1017/S0033291713002493 CrossRefPubMed

Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Radmark O, Kim S, Kim VN (2003) The nuclear RNase III Drosha initiates microRNA processing. Nature 425(6956):415–419. doi:10.1038/nature01957 CrossRefPubMed

Lehmann SM, Kruger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kalin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, Golenbock D, Schott E, Ploegh HL, Wulczyn FG, Lehnardt S (2012) An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci 15(6):827–835. doi:10.1038/nn.3113 CrossRefPubMed

Lesch KP, Timmesfeld N, Renner TJ, Halperin R, Roser C, Nguyen TT, Craig DW, Romanos J, Heine M, Meyer J, Freitag C, Warnke A, Romanos M, Schafer H, Walitza S, Reif A, Stephan DA, Jacob C (2008) Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. J Neural Transm 115(11):1573–1585. doi:10.1007/s00702-008-0119-3 CrossRefPubMed

Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB (2003) Prediction of mammalian microRNA targets. Cell 115(7):787–798CrossRefPubMed

Lionel AC, Crosbie J, Barbosa N, Goodale T, Thiruvahindrapuram B, Rickaby J, Gazzellone M, Carson AR, Howe JL, Wang Z, Wei J, Stewart AF, Roberts R, McPherson R, Fiebig A, Franke A, Schreiber S, Zwaigenbaum L, Fernandez BA, Roberts W, Arnold PD, Szatmari P, Marshall CR, Schachar R, Scherer SW (2011) Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD. Sci Transl Med 3(95):95ra75. doi:10.1126/scitranslmed.3002464 CrossRefPubMed

Lopez JP, Fiori LM, Gross JA, Labonte B, Yerko V, Mechawar N, Turecki G (2014) Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers. Int J Neuropsychopharmacol 17(1):23–32. doi:10.1017/S1461145713000941 CrossRefPubMed

Ludwig N, Leidinger P, Becker K, Backes C, Fehlmann T, Pallasch C, Rheinheimer S, Meder B, Stahler C, Meese E, Keller A (2016) Distribution of miRNA expression across human tissues. Nucleic Acids Res 44(8):3865–3877. doi:10.1093/nar/gkw116 CrossRefPubMedPubMedCentral

Maffioletti E, Tardito D, Gennarelli M, Bocchio-Chiavetto L (2014) Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders. Front Cell Neurosci 8:75. doi:10.3389/fncel.2014.00075 CrossRefPubMedPubMedCentral

Mick E, McGough JJ, Middleton FA, Neale B, Faraone SV (2011) Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 35(2):466–472. doi:10.1016/j.pnpbp.2010.11.037 CrossRefPubMed

Miller BH, Zeier Z, Xi L, Lanz TA, Deng S, Strathmann J, Willoughby D, Kenny PJ, Elsworth JD, Lawrence MS, Roth RH, Edbauer D, Kleiman RJ, Wahlestedt C (2012) MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function. Proc Natl Acad Sci USA 109(8):3125–3130. doi:10.1073/pnas.1113793109 CrossRefPubMedPubMedCentral

Moffitt TE, Houts R, Asherson P, Belsky DW, Corcoran DL, Hammerle M, Harrington H, Hogan S, Meier MH, Polanczyk GV, Poulton R, Ramrakha S, Sugden K, Williams B, Rohde LA, Caspi A (2015) Is adult ADHD a childhood-onset neurodevelopmental disorder? Evidence from a Four-Decade Longitudinal Cohort Study. Am J Psychiatry 172(10):967–977. doi:10.1176/appi.ajp.2015.14101266 CrossRefPubMedPubMedCentral

Moher D, Schulz KF, Simera I, Altman DG (2010) Guidance for developers of health research reporting guidelines. PLoS Med 7(2):e1000217. doi:10.1371/journal.pmed.1000217 CrossRefPubMedPubMedCentral

Moreau MP, Bruse SE, David-Rus R, Buyske S, Brzustowicz LM (2011) Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder. Biol Psychiatry 69(2):188–193. doi:10.1016/j.biopsych.2010.09.039 CrossRefPubMedPubMedCentral

Neale BM, Lasky-Su J, Anney R, Franke B, Zhou K, Maller JB, Vasquez AA, Asherson P, Chen W, Banaschewski T, Buitelaar J, Ebstein R, Gill M, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke E, Mulas F, Taylor E, Laird N, Lange C, Daly M, Faraone SV (2008) Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 147B(8):1337–1344. doi:10.1002/ajmg.b.30866 CrossRefPubMedPubMedCentral

Neale BM, Medland SE, Ripke S, Asherson P, Franke B, Lesch KP, Faraone SV, Nguyen TT, Schafer H, Holmans P, Daly M, Steinhausen HC, Freitag C, Reif A, Renner TJ, Romanos M, Romanos J, Walitza S, Warnke A, Meyer J, Palmason H, Buitelaar J, Vasquez AA, Lambregts-Rommelse N, Gill M, Anney RJ, Langely K, O’Donovan M, Williams N, Owen M, Thapar A, Kent L, Sergeant J, Roeyers H, Mick E, Biederman J, Doyle A, Smalley S, Loo S, Hakonarson H, Elia J, Todorov A, Miranda A, Mulas F, Ebstein RP, Rothenberger A, Banaschewski T, Oades RD, Sonuga-Barke E, McGough J, Nisenbaum L, Middleton F, Hu X, Nelson S (2010) Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49(9):884–897. doi:10.1016/j.jaac.2010.06.008 CrossRefPubMedPubMedCentral

Nelson PT, Wang WX (2010) MiR-107 is reduced in Alzheimer’s disease brain neocortex: validation study. J Alzheimers Dis 21(1):75–79. doi:10.3233/JAD-2010-091603 CrossRefPubMedPubMedCentral

Nemeth N, Kovacs-Nagy R, Szekely A, Sasvari-Szekely M, Ronai Z (2013) Association of impulsivity and polymorphic microRNA-641 target sites in the SNAP-25 gene. PLoS ONE 8(12):e84207. doi:10.1371/journal.pone.0084207 CrossRefPubMedPubMedCentral

Omran A, Elimam D, Shalaby S, Peng J, Yin F (2012) MicroRNAs: a light into the “black box” of neuropediatric diseases? NeuroMol Med 14(4):244–261. doi:10.1007/s12017-012-8193-y CrossRef

Perkins DO, Jeffries CD, Jarskog LF, Thomson JM, Woods K, Newman MA, Parker JS, Jin J, Hammond SM (2007) microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Genome Biol 8(2):R27. doi:10.1186/gb-2007-8-2-r27 CrossRefPubMedPubMedCentral

Pingault JB, Viding E, Galera C, Greven CU, Zheng Y, Plomin R, Rijsdijk F (2015) Genetic and environmental influences on the developmental course of attention-deficit/hyperactivity disorder symptoms from childhood to adolescence. JAMA Psychiatry 72(7):651–658. doi:10.1001/jamapsychiatry.2015.0469 CrossRefPubMed

Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA (2007) The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 164(6):942–948. doi:10.1176/appi.ajp.164.6.942 CrossRefPubMed

Polanczyk GV, Willcutt EG, Salum GA, Kieling C, Rohde LA (2014) ADHD prevalence estimates across three decades: an updated systematic review and meta-regression analysis. Int J Epidemiol 43(2):434–442. doi:10.1093/ije/dyt261 CrossRefPubMedPubMedCentral

Rehfeld F, Rohde AM, Nguyen DT, Wulczyn FG (2015) Lin28 and let-7: ancient milestones on the road from pluripotency to neurogenesis. Cell Tissue Res 359(1):145–160. doi:10.1007/s00441-014-1872-2 CrossRefPubMed

Russell VA, Sagvolden T, Johansen EB (2005) Animal models of attention-deficit hyperactivity disorder. Behav Brain Funct 1:9. doi:10.1186/1744-9081-1-9 CrossRefPubMedPubMedCentral

Sanchez-Mora C, Ramos-Quiroga JA, Garcia-Martinez I, Fernandez-Castillo N, Bosch R, Richarte V, Palomar G, Nogueira M, Corrales M, Daigre C, Martinez-Luna N, Grau-Lopez L, Toma C, Cormand B, Roncero C, Casas M, Ribases M (2013) Evaluation of single nucleotide polymorphisms in the miR-183-96-182 cluster in adulthood attention-deficit and hyperactivity disorder (ADHD) and substance use disorders (SUDs). Eur Neuropsychopharmacol 23(11):1463–1473. doi:10.1016/j.euroneuro.2013.07.002 CrossRefPubMed

Sanchez-Mora C, Ramos-Quiroga JA, Bosch R, Corrales M, Garcia-Martinez I, Nogueira M, Pagerols M, Palomar G, Richarte V, Vidal R, Arias-Vasquez A, Bustamante M, Forns J, Gross-Lesch S, Guxens M, Hinney A, Hoogman M, Jacob C, Jacobsen KK, Kan CC, Kiemeney L, Kittel-Schneider S, Klein M, Onnink M, Rivero O, Zayats T, Buitelaar J, Faraone SV, Franke B, Haavik J, Johansson S, Lesch KP, Reif A, Sunyer J, Bayes M, Casas M, Cormand B, Ribases M (2015) Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder. Neuropsychopharmacology 40(4):915–926. doi:10.1038/npp.2014.267 CrossRefPubMed

Santarelli DM, Beveridge NJ, Tooney PA, Cairns MJ (2011) Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia. Biol Psychiatry 69(2):180–187. doi:10.1016/j.biopsych.2010.09.030 CrossRefPubMed

Sery O, Paclt I, Drtilkova I, Theiner P, Kopeckova M, Zvolsky P, Balcar VJ (2015) A 40-bp VNTR polymorphism in the 3′-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism. Behav Brain Funct 11:21. doi:10.1186/s12993-015-0066-8 CrossRefPubMedPubMedCentral

Simon V, Czobor P, Balint S, Meszaros A, Bitter I (2009) Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry 194(3):204–211. doi:10.1192/bjp.bp.107.048827 CrossRefPubMed

Smalheiser NR, Lugli G, Zhang H, Rizavi H, Cook EH, Dwivedi Y (2014) Expression of microRNAs and other small RNAs in prefrontal cortex in schizophrenia, bipolar disorder and depressed subjects. PLoS ONE 9(1):e86469. doi:10.1371/journal.pone.0086469 CrossRefPubMedPubMedCentral

Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, Beazley C, Ingle CE, Dunning M, Flicek P, Koller D, Montgomery S, Tavare S, Deloukas P, Dermitzakis ET (2007) Population genomics of human gene expression. Nat Genet 39(10):1217–1224. doi:10.1038/ng2142 CrossRefPubMedPubMedCentral

Sullivan PF, Fan C, Perou CM (2006) Evaluating the comparability of gene expression in blood and brain. Am J Med Genet B Neuropsychiatr Genet 141B(3):261–268. doi:10.1002/ajmg.b.30272 CrossRefPubMed

Sun E, Shi Y (2015) MicroRNAs: Small molecules with big roles in neurodevelopment and diseases. Exp Neurol 268:46–53. doi:10.1016/j.expneurol.2014.08.005 CrossRefPubMed

Tardito D, Mallei A, Popoli M (2013) Lost in translation. New unexplored avenues for neuropsychopharmacology: epigenetics and microRNAs. Expert Opin Investig Drugs 22(2):217–233. doi:10.1517/13543784.2013.749237 CrossRefPubMed

Taurines R, Grünblatt E, Schecklmann M, Schwenck C, Albantakis L, Reefschlager L, Walitza S, Renner T, Gerlach M, Thome J, Romanos M (2011) Altered mRNA expression of monoaminergic candidate genes in the blood of children with attention deficit hyperactivity disorder and autism spectrum disorder. World J Biol Psychiatry 12(Suppl 1):104–108. doi:10.3109/15622975.2011.600297 CrossRefPubMed

Thapar A, Langley K, Asherson P, Gill M (2007) Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective. Br J Psychiatry 190:1–3. doi:10.1192/bjp.bp.106.027003 CrossRefPubMed

Vasudevan S, Tong Y, Steitz JA (2007) Switching from repression to activation: microRNAs can up-regulate translation. Science 318(5858):1931–1934. doi:10.1126/science.1149460 CrossRefPubMed

Wright C, Gupta CN, Chen J, Patel V, Calhoun VD, Ehrlich S, Wang L, Bustillo JR, Perrone-Bizzozero NI, Turner JA (2016) Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia. Transl Psychiatry 6:e724. doi:10.1038/tp.2015.211 CrossRefPubMedPubMedCentral

Wu L, Zhao Q, Zhu X, Peng M, Jia C, Wu W, Zheng J, Wu XZ (2010) A novel function of microRNA let-7 days in regulation of galectin-3 expression in attention deficit hyperactivity disorder rat brain. Brain Pathol 20(6):1042–1054. doi:10.1111/j.1750-3639.2010.00410.x CrossRefPubMed

Wu LH, Peng M, Yu M, Zhao QL, Li C, Jin YT, Jiang Y, Chen ZY, Deng NH, Sun H, Wu XZ (2015) Circulating MicroRNA Let-7d in attention-deficit/hyperactivity disorder. NeuroMol Med 17(2):137–146. doi:10.1007/s12017-015-8345-y CrossRef

Wu YE, Parikshak NN, Belgard TG, Geschwind DH (2016) Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder. Nat Neurosci 19(11):1463–1476. doi:10.1038/nn.4373 CrossRefPubMed

Wu LH, Cheng W, Yu M, He BM, Sun H, Chen Q, Dong YW, Shao XT, Cai QQ, Peng M, Wu XZ (2017) Nr3C1-Bhlhb2 Axis dysregulation is involved in the development of attention deficit hyperactivity. Mol Neurobiol 54(2):1196–1212. doi:10.1007/s12035-015-9679-z CrossRefPubMed

Xu Y, Chen XT, Luo M, Tang Y, Zhang G, Wu D, Yang B, Ruan DY, Wang HL (2015) Multiple epigenetic factors predict the attention deficit/hyperactivity disorder among the Chinese Han children. J Psychiatr Res 64:40–50. doi:10.1016/j.jpsychires.2015.03.006 CrossRefPubMed

Yang L, Neale BM, Liu L, Lee SH, Wray NR, Ji N, Li H, Qian Q, Wang D, Li J, Faraone SV, Wang Y, Psychiatric GCAS, Doyle AE, Reif A, Rothenberger A, Franke B, Sonuga-Barke EJ, Steinhausen HC, Buitelaar JK, Kuntsi J, Biederman J, Lesch KP, Kent L, Asherson P, Oades RD, Loo SK, Nelson SF, Faraone SV, Smalley SL, Banaschewski T, Arias Vasquez A, Todorov A, Charach A, Miranda A, Warnke A, Thapar A, Neale BM, Cormand B, Freitag C, Mick E, Mulas F, Middleton F, HakonarsonHakonarson H, Palmason H, Schafer H, Roeyers H, McGough JJ, Romanos J, Crosbie J, Meyer J, Ramos-Quiroga JA, Sergeant J, Elia J, Langely K, Nisenbaum L, Romanos M, Daly MJ, Ribases M, Gill M, O’Donovan M, Owen M, Casas M, Bayes M, Lambregts-Rommelse N, Williams N, Holmans P, Anney RJ, Ebstein RP, Schachar R, Medland SE, Ripke S, Walitza S, Nguyen TT, Renner TJ, Hu X (2013) Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants. Am J Med Genet B Neuropsychiatr Genet 162B(5):419–430. doi:10.1002/ajmg.b.32169 CrossRefPubMed

Ye C, Hu Z, Wu E, Yang X, Buford UJ, Guo Z, Saveanu RV (2016) Two SNAP-25 genetic variants in the binding site of multiple microRNAs and susceptibility of ADHD: a meta-analysis. J Psychiatr Res 81:56–62. doi:10.1016/j.jpsychires.2016.06.007 CrossRefPubMed

Zayats T, Athanasiu L, Sonderby I, Djurovic S, Westlye LT, Tamnes CK, Fladby T, Aase H, Zeiner P, Reichborn-Kjennerud T, Knappskog PM, Knudsen GP, Andreassen OA, Johansson S, Haavik J (2015) Genome-wide analysis of attention deficit hyperactivity disorder in Norway. PLoS ONE 10(4):e0122501. doi:10.1371/journal.pone.0122501 CrossRefPubMedPubMedCentral

Ziats MN, Rennert OM (2014) Identification of differentially expressed microRNAs across the developing human brain. Mol Psychiatry 19(7):848–852. doi:10.1038/mp.2013.93 CrossRefPubMed

Title: Emerging role of miRNA in attention deficit hyperactivity disorder: a systematic review
Authors: Saurabh Srivastav
Susanne Walitza
Edna Grünblatt
Publication date: 01-03-2018
Publisher: Springer Vienna
Published in: ADHD Attention Deficit and Hyperactivity Disorders / Issue 1/2018
Print ISSN: 1866-6116
Electronic ISSN: 1866-6647
DOI: https://doi.org/10.1007/s12402-017-0232-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Emerging role of miRNA in attention deficit hyperactivity disorder: a systematic review

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2018

Subjective Distress Associated with Adult ADHD: evaluation of a new self-report

Physiological substrates of executive functioning: a systematic review of the literature

Prevalence of sexual dysfunctions and other sexual disorders in adults with attention-deficit/hyperactivity disorder compared to the general population

Acknowledgement to reviewers 2017

Positive alcohol expectancies mediate associations between ADHD behaviors and alcohol-related problems among college students

Perception in attention deficit hyperactivity disorder