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Published in: Journal of Hematopathology 1/2016

01-03-2016 | Case Report

Bilateral conjunctival pediatric follicular lymphoma

Authors: Alia Nazarullah, Luke Dietz, Kenneth Wright, Serhan Alkan, Qin Huang

Published in: Journal of Hematopathology | Issue 1/2016

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Abstract

Follicular lymphoma (FL) is the most common type of B cell non-Hodgkin lymphoma in Western counties. FL is usually seen in adults and is very uncommon in pediatric population. Pediatric follicular lymphoma (PFL) is a rare indolent lymphoma characteristically seen in pediatric population, usually involving cervical lymph nodes, Waldeyer ring, and testis. They pose significant diagnostic challenges due to morphologic overlap with much more common florid follicular hyperplasia and lack of typical t(14;18)IgH/BCL2 fusion and BCL-2 protein expression. We present the case of a 10-year-old male with bilateral conjunctival nodules, showing characteristic morphologic and immunophenotypic features of PFL with demonstrated clonal B cell immunoglobulin heavy chain gene rearrangement. Of note, the neoplastic cells expressed MUM1, MYC, and IgM, suggestive of a different disease pathogenesis from adult FL.
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Metadata
Title
Bilateral conjunctival pediatric follicular lymphoma
Authors
Alia Nazarullah
Luke Dietz
Kenneth Wright
Serhan Alkan
Qin Huang
Publication date
01-03-2016
Publisher
Springer Berlin Heidelberg
Published in
Journal of Hematopathology / Issue 1/2016
Print ISSN: 1868-9256
Electronic ISSN: 1865-5785
DOI
https://doi.org/10.1007/s12308-015-0260-5

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