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01-09-2013 | Case Report

Diffuse variant of lymphocyte-predominant Hodgkin lymphoma: a diagnostic challenge

Authors: Yuanming Zhang, Ihsane Ouansafi, Wayne Tam, John P. Leonard, Attilio Orazi

Published in: Journal of Hematopathology | Issue 3/2013

Abstract

The diffuse variant of nodular lymphocyte-predominant Hodgkin lymphoma (D-LPHL) is exceedingly rare. Here we report a case of D-LPHL in a 35-year-old Caucasian female who presented with left cervical and right axillary lymphadenopathy. Histopathologic examination reveals large atypical lymphoid cells resembling lymphocyte-predominant (LP) cells in a background of reactive T cells, B cells, and histiocytes. Extensive immunohistochemical study demonstrates that these large atypical lymphoid cells express characteristic phenotype of LP cells including CD20, CD79a, BOB-1, OCT-2, BCL-6, and EMA and are negative for CD30 and fascin. The diffuse nature of the lymphoid proliferation is confirmed by negative CD21, CD23, and CD35 stains showing a complete lack of follicular dendritic cell meshworks. The associated T cell microenvironment shows increased CD57(+) T cells arranged into peritumoral cell rosettes. The diagnostic criteria of this case are discussed and a review of the literature about the differential diagnosis is provided.

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Title: Diffuse variant of lymphocyte-predominant Hodgkin lymphoma: a diagnostic challenge
Authors: Yuanming Zhang
Ihsane Ouansafi
Wayne Tam
John P. Leonard
Attilio Orazi
Publication date: 01-09-2013
Publisher: Springer Berlin Heidelberg
Published in: Journal of Hematopathology / Issue 3/2013
Print ISSN: 1868-9256
Electronic ISSN: 1865-5785
DOI: https://doi.org/10.1007/s12308-012-0162-8

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Diffuse variant of lymphocyte-predominant Hodgkin lymphoma: a diagnostic challenge

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