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01-06-2013 | Case Report

HIV-associated plasmablastic multicentric Castleman disease with microlymphoma coinfected with HHV8 and EBV

Authors: Deniz Peker, Serhan Alkan, Ling Zhang, Antonio Martinez

Published in: Journal of Hematopathology | Issue 2/2013

Abstract

Human herpesvirus-8 (HHV8) is associated with various disorders including multicentric Castleman disease (MCD) and related neoplasms. Epstein–Barr virus (EBV) is also important in development of certain hematopoietic neoplasms. We report a case of HIV + MCD, plasmablastic type, with microlymphoma with large cells colonizing within germinal centers with HHV8 and EBV coinfection. A 66-year-old HIV + man on antiviral therapy presented with fever, weakness, lymphadenopathy, and hepatosplenomegaly. Biopsy of an axillary lymph node showed features of MCD and intrafollicular colonization of HHV8+, EBV + plasmablasts coexpressing CD138, MUM1, LMO2, CD20, and IgM. The neoplastic cells were also positive for MYC protein expression. The patient died shortly due to infection and multisystem failure after diagnosis without any other evidence of large cell lymphoma or effusion lymphoma. This case has clinical features compatible with a rare type of HHV8+ and EBV + MCD-associated plasmablastic lymphoproliferative disorder with a germinotropic pattern showing possible MYC gene deregulation.

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Title: HIV-associated plasmablastic multicentric Castleman disease with microlymphoma coinfected with HHV8 and EBV
Authors: Deniz Peker
Serhan Alkan
Ling Zhang
Antonio Martinez
Publication date: 01-06-2013
Publisher: Springer-Verlag
Published in: Journal of Hematopathology / Issue 2/2013
Print ISSN: 1868-9256
Electronic ISSN: 1865-5785
DOI: https://doi.org/10.1007/s12308-012-0156-6

At a glance: The STEP trials

Springer Medicine

HIV-associated plasmablastic multicentric Castleman disease with microlymphoma coinfected with HHV8 and EBV

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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